THE ROLE OF SMALL NON CODING RNAS IN BONE MARROW MEDIATED TUMOR ANGIOGENESIS

尽管在治疗和诊断方面取得了进展，癌症仍然是导致死亡的主要潜在原因，占澳大利亚每年死亡人数的三分之一（ABS统计数据）。www.abs.gov.au）。了解肿瘤血管形成和扩散过程的能力具有巨大的经济和社会成果。事实上，迄今为止开发的最有效的抗血管生成疗法Avastin（又名Bevacizumab）尽管仅提供适度的生存优势（4-6个月），但其年销售额为数十亿美元。 microRNA代表了一种相对较新发现的基因活性调节形式。在这一领域发挥关键的领导作用将使澳大利亚科学处于国际研究倡议的前沿。

Despite advances in treatment and diagnosis cancer remains the leading underlying cause of deaths, representing about a third of all deaths each year in Australia (ABS stats. www.abs.gov.au). The ability to understand the process of tumour vascularisation and spread has enormous economic and social outcomes. Indeed, the most effective anti-angiogenic therapy developed to date Avastin (aka Bevacizumab), although providing only a modest survival advantage (4-6 months) has annual sales of several billion dollars. microRNA represent a relatively newly discovered form of gene activity regulation. Taking a key leadership role in this area will put Australian science at the forefront of international research initiatives.