Understanding biological membranes in atomic detail

了解生物膜的原子细节

• 批准号: DP160103414
• 负责人: Prof Alan Mark
• 金额: $ 25.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103414
• 关键词: Understanding; biological; membranes; atomic; detail

The aim of the project is to develop the capacity to represent specific mammalian, fungal and bacterial membranes in atomic detail and to use such models to understand the role of membrane composition in the structure and dynamics of membrane proteins at an atomic level. Membrane protein assemblies are the ultimate nanoscale machines. Understanding these sub-cellular components is both a fundamental theoretical challenge and of widespread practical importance in biochemistry, structural biology and medicine. By representing in detail the complexity of biological membranes, the project aims to elucidate the role played by specific membrane components in determining the mechanism of action of proteins involved in transport and signal transduction in context.

该项目的目的是发展以原子细节表示特定哺乳动物、真菌和细菌膜的能力，并使用这种模型在原子水平上了解膜组成在膜蛋白结构和动力学中的作用。膜蛋白组件是最终的纳米级机器。了解这些亚细胞成分在生物化学、结构生物学和医学中既是一个基本的理论挑战，也具有广泛的实践意义。通过详细介绍生物膜的复杂性，该项目旨在阐明特定的膜组件在确定参与运输和信号转导的蛋白质的作用机制方面所起的作用。