Novel amphiphilic polymers to elucidate the effect of architecture on micellization

新型两亲聚合物阐明结构对胶束化的影响

• 批准号: 1412439
• 负责人: Scott Grayson
• 金额: $ 54万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1412439&HistoricalAwards=false
• 关键词: Novel; amphiphilic; polymers; elucidate; effect

Hybrid polymers that exhibit regions of contrasting solubility (e.g. water-soluble versus oil-soluble) are termed "amphiphilic polymers". Amphiphilic polymers are potentially useful in a range of applications including detergents, emulsifying agents, etc. Some of them have already been utilized commercially in the cosmetic and pharmaceutical industries. The majority of previous research on amphiphilic polymers has focused on polymeric components that are simple linear strands. Drs. Scott Grayson, Alina Alb, and Henry Ashbaugh at Tulane University explore the synthesis of various "non-linear" architectures and study their properties using both computer modeling and physical analysis to identify unique and useful materials. As an integral component, undergraduate and graduate students are trained in state-of-the-art laboratory techniques to provide them with a technical foundation for careers in the polymer industry. In addition, this project supports ongoing outreach efforts in New Orleans public school chemistry classes to demonstrate to the high school students the connections between textbook chemistry and its real-world applications.This project focuses specifically on two classes of polymer architecture: non-linear amphiphilic homopolymers (AHPs) and "dendrimer-like" star polymers. This research effort simultaneously investigates the synthesis of new monomers that better address the need for uncharged amphiphiles, while exploring novel cyclic, star, and caged architectures. The second class of polymers, dendrimer-like star polymers, enables the incorporation of branching not only at the core (like traditional star polymers) but also at the interface between the polar and non-polar blocks. This project develops modular synthetic approaches to star-dendritic-linear and graft-dendritic-linear polymers, which allow the length of the linear blocks and dendron generation to be independently tuned. The synthesis of these unique architectures is complemented by detailed theoretical modeling (Replica Exchange dynamics) and state of the art physical characterization (e.g., light scattering couple with automatic continuous mixing). The relationship between the structural parameters, the resultant self-assembly behavior, and polymer properties are explored in detail.

表现出不同溶解度区域（例如水溶性与油溶性）的杂化聚合物被称为“两亲聚合物”。 两亲性聚合物在洗涤剂、乳化剂等一系列应用中具有潜在的用途，其中一些已经在化妆品和制药工业中得到商业应用。 以前对两亲性聚合物的大部分研究都集中在简单线性链的聚合物组分上。 杜兰大学的Scott Grayson、Alina Alb和亨利阿什博博士探索各种“非线性”结构的合成，并使用计算机建模和物理分析来研究它们的特性，以识别独特而有用的材料。 作为一个不可分割的组成部分，本科生和研究生接受最先进的实验室技术培训，为他们在聚合物行业的职业生涯提供技术基础。 此外，该项目还支持新奥尔良公立学校化学课程的持续推广工作，向高中生展示教科书化学与其实际应用之间的联系。该项目特别关注两类聚合物结构：非线性两亲性均聚物（AHP）和“树枝状”星星聚合物。 这项研究工作同时调查新的单体，更好地解决不带电的两亲物的需要，同时探索新的环状，星星，和笼状结构的合成。 第二类聚合物，树枝状星星聚合物，不仅能够在核（如传统的星星聚合物）处引入支化，而且能够在极性和非极性嵌段之间的界面处引入支化。 该项目开发了星形-树枝状-线性和接枝-树枝状-线性聚合物的模块化合成方法，该方法允许独立调节线性嵌段和树枝化基元的长度。 这些独特架构的合成由详细的理论建模（交换动力学）和最先进的物理表征（例如，光散射耦合自动连续混合）。 结构参数之间的关系，所得的自组装行为，和聚合物的性能进行了详细的探讨。