SusChem: IUPAC: Earth Abundant Metal Catalyzed Borylations

该项目由美国国家科学基金会化学部化学催化项目资助，由弗吉尼亚理工学院和州立大学的Webster L. Santos教授负责研究铜硼基配合物的反应性，开发铜催化剂（特别关注那些含有廉价配体的催化剂），并探索新的溶剂，包括水，用于硼化和随后的交叉偶联过程。该团队对明确定义的铜硼基、芳基和烷基配合物的结构和反应性以及相关的催化剂筛选研究进行了基础实验和理论研究。本研究开发了一种新的催化剂系统，用富含地球的金属（如铜）取代稀有，昂贵和有毒的过渡金属催化剂（Pd, Pt, Rh， Ir等）。调查通过利用水作为溶剂而不是有机溶液来最大限度地减少有害废物的产生。本项目由Todd B. Marder教授（Universität w<s:1> rzburg, Germany）和Yao Fu教授（中国科学技术大学）合作完成。这三个小组结合各自的专业领域，为生产商品化学品提供更可持续的合成方法。这项工作的更广泛影响还包括对研究生的领导能力培训以及国际思想和专业知识的交流。

This project, funded by the Chemical Catalysis Program of the NSF Division of Chemistry, to Professor Webster L. Santos of the Virginia Polytechnic Institute and State University examines the reactivity of copper boryl complexes, develops copper catalysts (with particular focus on those containing inexpensive ligands), and explores new solvents, including water, for borylation and subsequent cross-coupling processes. The team conducts fundamental experimental and theoretical studies on the structures and reactivities of well-defined copper boryl, aryl and alkyl complexes as well as associated catalyst screening studies. This research develops novel catalyst systems that replace rare, expensive, and toxic transition metal catalysts (Pd, Pt, Rh, Ir, etc.) with earth abundant metals such as copper. The investigations minimize the production of hazardous waste by utilizing water as solvent rather than an organic solution.This project is conducted in collaboration with Professor Todd B. Marder (Universität Würzburg, Germany) and Professor Yao Fu (University of Science and Technology China). Together, the three groups combine their separate areas of expertise to provide more sustainable synthetic methods for the production of commodity chemicals. The broader impacts of this work also include leadership training for graduate students and an international exchange of ideas and expertise.