SusChem: IUPAC: Earth Abundant Metal Catalyzed Borylations

SusChem：IUPAC：地球丰富的金属催化硼化反应

• 批准号: 1414458
• 负责人: Webster Santos
• 金额: $ 39万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414458&HistoricalAwards=false
• 关键词: SusChem; IUPAC; Earth; Abundant; Metal

This project, funded by the Chemical Catalysis Program of the NSF Division of Chemistry, to Professor Webster L. Santos of the Virginia Polytechnic Institute and State University examines the reactivity of copper boryl complexes, develops copper catalysts (with particular focus on those containing inexpensive ligands), and explores new solvents, including water, for borylation and subsequent cross-coupling processes. The team conducts fundamental experimental and theoretical studies on the structures and reactivities of well-defined copper boryl, aryl and alkyl complexes as well as associated catalyst screening studies. This research develops novel catalyst systems that replace rare, expensive, and toxic transition metal catalysts (Pd, Pt, Rh, Ir, etc.) with earth abundant metals such as copper. The investigations minimize the production of hazardous waste by utilizing water as solvent rather than an organic solution.This project is conducted in collaboration with Professor Todd B. Marder (Universität Würzburg, Germany) and Professor Yao Fu (University of Science and Technology China). Together, the three groups combine their separate areas of expertise to provide more sustainable synthetic methods for the production of commodity chemicals. The broader impacts of this work also include leadership training for graduate students and an international exchange of ideas and expertise.

这个项目由美国国家科学基金会化学部化学催化计划资助，由韦伯斯特L.弗吉尼亚理工学院和州立大学的桑托斯研究了铜硼基络合物的反应性，开发了铜催化剂（特别关注那些含有廉价配体的催化剂），并探索了新的溶剂，包括水，用于硼化和随后的交叉偶联过程。 该团队对定义明确的铜硼基，芳基和烷基络合物的结构和反应性以及相关的催化剂筛选研究进行了基础实验和理论研究。这项研究开发了新的催化剂系统，取代稀有，昂贵和有毒的过渡金属催化剂（Pd，Pt，Rh，Ir等）。与地球上丰富的金属如铜。 该研究利用水而不是有机溶液作为溶剂，将危险废物的产生降至最低。该项目是与托德教授B合作进行的。Marder（德国维尔茨堡大学）和姚福教授（中国科技大学）。 这三个集团联合收割机将各自的专业领域结合起来，为商品化学品的生产提供更可持续的合成方法。 这项工作的更广泛影响还包括对研究生的领导能力培训以及思想和专业知识的国际交流。

项目成果

Copper(II)-Catalyzed β-Borylation of Acetylenic Esters in Water

铜(II) 催化水中乙炔酯的β-硼化反应

• DOI: 10.1055/s-0034-1380524
• 发表时间: 2015
• 期刊: Synthesis
• 作者: Peck, Cheryl;Calderone, Joseph;Santos, Webster
• 通讯作者: Santos, Webster

Regio- and Chemoselective Diboration of Allenes with Unsymmetrical Diboron: Formation of Vinyl and Allyl Boronic Acid Derivatives

• DOI: 10.1021/acscatal.5b00387
• 发表时间: 2015-04-01
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Guo, Xi;Nelson, Amanda K.;Santos, Webster L.
• 通讯作者: Santos, Webster L.