EAPSI: Investigation of bacteria-inspired robotic swimmers

EAPSI：对细菌启发的机器人游泳者的研究

• 批准号: 1414661
• 负责人: Jamel Ali
• 金额: $ 0.51万
• 依托单位: Ali Jamel
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414661&HistoricalAwards=false
• 关键词: EAPSI; Investigation; bacteria; inspired; robotic

Currently there is a great deal of interest in microscale robotics for many applications, such as drug delivery. From literature, it is clear that the main reasons why microrobototics has not yet been developed for clinical use is the lack of sufficient energy and propulsion systems, as well as a lack of control systems needed for precise manipulation of these devices. Although material synthesis and processing have been rapidly advancing, no man-made material exhibits the diverse array of robustness and function inherent in many biological systems. A possible resource for such active materials exists within many microorganisms, namely bacterial flagella. One potential application of flagella is the use of these biomaterials as mechanical motors in robotic microswimmers. This research aims to fabricate and control bacterial-inspired robotic microswimmers. Dr.Jinseok Kim, at the Center of Bionics at Korea Institute of Science and Technology (KIST) is currently investigating the use of such microrobots for minimally invasive surgery and targeted drug delivery. The researchers at KIST have expertise in studying microswimming behavior as well as capability to control microswimmers though various stimulations such as magnetotaxis. Flagella are an ideal system to use for a variety of microbiorobotic systems because they can convert rotational motion into translation motion. Also, as mechanical devices, flagella have extraordinary properties, allowing them to act as mechanical transducers. Furthermore, billions of flagella are readily available through inexpensive cell culturing techniques. Expertise and equipment, along with equipment to record, track, and analyze bacterial behavior is also present at KIST. Using KIST's equipment for high resolution fluorescence imaging of micro size objects, flagellated artificial bacteria will be developed and investigated for their ability to swim at low Reyonds number. In addition, the ability of these robotic swimmers to navigate controllably in biologically realistic fluids will also be investigated. This NSF EAPSI award is funded in collaboration with the National Research Foundation of Korea.

目前，人们对微型机器人的许多应用（例如药物输送）非常感兴趣。从文献中可以清楚地看出，微型机器人技术尚未开发用于临床的主要原因是缺乏足够的能量和推进系统，以及缺乏精确操纵这些设备所需的控制系统。尽管材料合成和加工已经迅速发展，但没有一种人造材料能够表现出许多生物系统固有的多种稳健性和功能。这种活性物质的可能来源存在于许多微生物中，即细菌鞭毛。鞭毛的一项潜在应用是使用这些生物材料作为机器人微型游泳器的机械马达。这项研究旨在制造和控制受细菌启发的微型游泳机器人。韩国科学技术研究院 (KIST) 仿生中心的 Jinseok Kim 博士目前正在研究使用此类微型机器人进行微创手术和靶向药物输送。 KIST 的研究人员拥有研究微型游泳行为的专业知识，以及通过趋磁等各种刺激来控制微型游泳者的能力。 鞭毛是用于各种微生物机器人系统的理想系统，因为它们可以将旋转运动转换为平移运动。此外，作为机械装置，鞭毛具有非凡的特性，使它们能够充当机械传感器。此外，通过廉价的细胞培养技术可以轻松获得数十亿鞭毛。 KIST 还拥有专业知识和设备，以及记录、跟踪和分析细菌行为的设备。 利用 KIST 的设备对微型物体进行高分辨率荧光成像，将开发有鞭毛的人造细菌并研究其在低雷诺数下游泳的能力。此外，还将研究这些机器人游泳者在生物真实流体中可控导航的能力。该 NSF EAPSI 奖项是与韩国国家研究基金会合作资助的。