EAPSI: Stimuli-responsive capsules from polymer-covered gold nanorods

EAPSI：由聚合物覆盖的金纳米棒制成的刺激响应胶囊

• 批准号: 1414688
• 负责人: Rachel Letteri
• 金额: $ 0.51万
• 依托单位: Letteri Rachel A
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414688&HistoricalAwards=false
• 关键词: EAPSI; Stimuli; responsive; capsules; polymer

'Smart' materials that respond to external stimuli, such as a change in temperature, pH, ionic strength, light exposure, or electric field, are the subject of a large body of research for applications that range from artificial muscles to sensors to the delivery of therapeutics. This project will investigate the stimuli-responsive behavior of oil-in-water droplets stabilized by polymer-covered gold nanorods (rod-shaped nanometer-sized gold particles, Au NRs), which are responsive to temperature, salt concentration, and light. Dr. Hongwei Duan, an expert in assemblies composed of polymer-covered particles, at Nanyang Technological University in Singapore will served as the host for this research. Placing special materials, such as Au NRs and polymers, at the oil-water interface of these droplets will afford new materials that hold great promise as highly functional, responsive systems.Assembling polymer-nanoparticle composites into two- or three-dimensional structures affords properties distinct from the individual components that are broadly interesting for chemistry, physics, engineering, and biology. This project will involve the incorporation of salt- and temperature-responsive zwitterionic polymers onto Au NRs. The versatility of polymer chemistry lends itself to easily combine stimuli-responsive functional groups with moieties that facilitate cross-linking and binding to gold into the same polymer, while Au NRs are ideal components of smart materials due to their biocompatibility and inherent ability to convert light into heat. The nanocomposites will be assembled at the oil-water interface, on droplets, and subsequently cross-linked into mechanically robust capsules. The response of these assemblies to external stimuli (i.e. salt, temperature, and light) will be studied by optical microscopy and by surface enhanced Raman scattering (SERS). To demonstrate the utility of these capsules for encapsulation, the uptake and release of a dye will be monitored. This NSF EAPSI award is funded in collaboration with the National Research Foundation of Singapore.

对外部刺激做出反应的“智能”材料，例如温度，pH值，离子强度，光照或电场的变化，是大量研究的主题，应用范围从人造肌肉到传感器到治疗药物的输送。本项目将研究由聚合物覆盖的金纳米棒（棒状纳米尺寸的金颗粒，Au NRs）稳定的水包油液滴的刺激响应行为，其对温度，盐浓度和光敏感。新加坡南洋理工大学的Hongwei Duan博士是由聚合物覆盖的颗粒组成的组件的专家，他将担任这项研究的主持人。将特殊材料，如Au NR和聚合物，放置在这些液滴的油-水界面上，将提供新的材料，作为高度功能化的响应系统，将聚合物-纳米颗粒复合材料组装成二维或三维结构，提供与化学，物理，工程和生物学广泛感兴趣的单个组分不同的特性。该项目将涉及将盐和温度响应的两性离子聚合物结合到Au NR上。聚合物化学的多功能性使其本身易于将联合收割机刺激响应性官能团与促进交联和结合金的部分结合到同一聚合物中，而Au NR由于其生物相容性和将光转化为热的固有能力而成为智能材料的理想组分。纳米复合材料将组装在油-水界面，液滴上，随后交联成机械坚固的胶囊。将通过光学显微镜和表面增强拉曼散射（Sers）研究这些组件对外部刺激（即盐、温度和光）的响应。为了证明这些胶囊用于包封的效用，将监测染料的摄取和释放。这个NSF EAPSI奖是与新加坡国家研究基金会合作资助的。