Automated Discovery and Screening of Stimuli-Responsive Porous Liquids

刺激响应多孔液体的自动发现和筛选

• 批准号: 2896345
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2896345
• 关键词: Automated; Discovery; Screening; Stimuli; Responsive

Porous liquids are an emerging class of porous materials that combine the properties of a microporous solid with the fluidity of a liquid. By incorporating intrinsic porosity in these liquids, properties that are difficult to achieve with conventional non-porous liquids are accessible, such as increased gas uptake and guest selectivity due to the presence of permanent tailorable pores. A range of porous liquids have now been reported, developed by translating porous solids into the liquid state, including porous organic cages (POCs), metal-organic cages (MOCs), covalent-organic frameworks (COFs), and metal-organic frameworks (MOFs). The gas capacity of these different porous liquids has been quite widely studied, with subsequent release of the gas relying on molecular displacement with liquid guests, pressure or temperature swings, or sonication. Recently, we reported the formation of high cavity concentration porous liquids using POCs - discrete molecules containing permanent molecular cavities accessible through windows - and demonstrated their ability to exhibit increased uptake of a range of gases (e.g., CO2, CH4, Xe, SF6) over neat liquids (Nature, 2015, 527, 216; Chem. Sci., 2017, 8, 2640; Angew. Chem. Int. Ed., 2020, 59, 7362; Adv. Funct. Mater., 2021, 31, 2106116). Despite these advances, the incorporation of stimuli-responsive porous materials into porous liquids, such as fluorescent or photoresponsive species, is much less investigated, but could offer additional advantages and/or use in different applications. For example, fluorescent porous liquids could be used as small molecule sensors, and photoresponsive liquids could enable controlled gas release using light. Recent proof-of-concept studies in the Greenaway group have proven that both types of these stimuli-responsive porous liquids are accessible, but the design and synthesis of both the initial porous material and subsequent porous liquid was time-consuming and the resultant material properties non-optimised. This project will build on these initial results, and our previous work on high-throughput POC synthesis and porous liquid discovery (Nature Commun., 2018, 9, 2849; Chem. Sci., 2019, 10, 9454), to screen and develop new stimuli-responsive porous liquids, followed by high-throughput screening of both their porous and optical properties (fluorescence, photoswitching).

多孔液体是一类新兴的多孔材料，将微孔固体的性质与液体的流动性结合在一起。通过在这些液体中融合固有的孔隙度，可以使用常规非孔液体难以实现的特性，例如由于存在永久性定制毛孔而导致的气体吸收和客人选择性增加。现在已经报道了一系列多孔液体，通过将多孔固体转化为液态，包括多孔有机笼（POC），金属有机笼（MOC），共价有机框架（COFS）和金属有机框架（MOF）（MOF）。这些不同的多孔液体的气体容量已经进行了广泛的研究，随后释放了与液体客人，压力或温度波动或超声处理的分子位移。 Recently, we reported the formation of high cavity concentration porous liquids using POCs - discrete molecules containing permanent molecular cavities accessible through windows - and demonstrated their ability to exhibit increased uptake of a range of gases (e.g., CO2, CH4, Xe, SF6) over neat liquids (Nature, 2015, 527, 216; Chem. Sci., 2017, 8, 2640; Angew. Chem. Int。，2020，59，7362；尽管有这些进展，但刺激反应性的多孔材料（例如荧光或光响应物种）的研究少得多，但可以提供更多的优势和/或在不同的应用中提供。例如，荧光多孔液体可以用作小分子传感器，并且光反应液体可以使用光释放受控气体。在Greenaway组中的最新概念验证研究证明，这两种刺激性反应性多孔液体都是可访问的，但是初始多孔材料和随后的多孔液体的设计和合成都是耗时的，而由此产生的材料特性不合适。该项目将基于这些最初的结果，以及我们先前在高通量POC合成和多孔液体发现方面的工作（Nature Commun。，2018，9，2849;Chem。Sci。，2019，10，9454），以筛选和开发新的刺激性反应性多孔液体，随后既有毛孔和光孔属性的高度筛选（随后），并进行了多孔和光孔的质量（效率和光孔）的照片（繁华的照片）（繁华的照片）（繁华的）。