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Center for Theoretical Biological Physics - Houston

理论生物物理中心 - 休斯顿

基本信息

批准号：
1427654
负责人：
Jose Onuchic
金额：
$ 1175万
依托单位：
William Marsh Rice University
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2022-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1427654&HistoricalAwards=false
关键词：
Center Theoretical Biological Physics Houston

项目摘要

Theoretical physics has become increasingly important in understanding complex living systems and is positioned to play a key role in addressing phenomena and behavior on the cellular and multicellular level. Investigations on this scale can also lead to new fundamental theoretical physics principles and advances. This Physics Frontiers Centers (PFC) award to the Center for Theoretical Biological Physics - Houston (CTBP-H) will continue work begun during the past PFC awards at the interface of theoretical physics and biology. The CTBP-H will use information from biomolecules, self-organization in living and non-living material, and non-equilibrium statistical physics in order to create a theoretical biological physics framework for cells and multicellular units. Through interactions with local medical institutions the work can impact biomedicine. Investigations of the self-organization of small-scale matter can impact nanoscale technology and material design. The CTBP-H will continue to provide unique training and fostering of young scientists in biological physics. It will support postdoctoral, graduate, and summer undergraduate research, and also reach underrepresented groups at the University of Houston. In addition, the CTBP-H will act as a focal point of scientific community activities, hosting a visiting scholars program, running workshops, and coordinating student networks.The CTBP-H will be working to find new fundamental principles and paradigms to understand the complex behavior of cells, as well as the coordination of cells into multicellular functional units. The major research activities include: advancing the understanding of gene-based information storage and utilization, developing theoretical frameworks for the mechanical aspects of eukaryotic cells, and combining these insights to study the self-organization of cells into multicellular biofilms and tissues. In collaboration with local medical centers they will apply their newfound insights from biological physics in biomedical contexts.This Physics Frontiers Centers award is co-funded by the Physics Frontiers Centers Program in the Division of Physics, the Chemical Theory, Models and Computational Methods Program in the Division of Chemistry, and the Condensed Matter and Materials Theory Program in the Division of Materials Research within the Directorate of Mathematical and Physical Sciences, and by the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences within the Directorate for Biological Sciences.

理论物理学在理解复杂的生命系统方面变得越来越重要，并且在解决细胞和多细胞水平上的现象和行为方面发挥着关键作用。这种规模的研究也可以导致新的基础理论物理学原理和进展。这个物理前沿中心（PFC）奖理论生物物理中心-休斯顿（CTBP-H）将继续在理论物理和生物学的接口在过去的PFC奖开始的工作。CTBP-H将使用来自生物分子、生物和非生物材料中的自组织以及非平衡统计物理的信息，为细胞和多细胞单位创建理论生物物理框架。通过与当地医疗机构的互动，这项工作可以影响生物医学。对小尺度物质自组织的研究可以影响纳米技术和材料设计。CTBP-H将继续提供独特的培训和培养生物物理学领域的年轻科学家。它将支持博士后，研究生和夏季本科生研究，并在休斯顿大学达到代表性不足的群体。此外，CTBP-H还将作为科学社群活动的中心，举办访问学者项目，举办研讨会，协调学生网络。CTBP-H将致力于寻找新的基本原理和范式，以了解细胞的复杂行为，以及细胞协调成多细胞功能单元。主要研究活动包括：推进对基于基因的信息存储和利用的理解，为真核细胞的机械方面开发理论框架，并结合这些见解来研究细胞自组织成多细胞生物膜和组织。在与当地的医疗中心合作，他们将应用他们的新发现的见解，从生物物理学在生物医学背景。这个物理前沿中心奖是共同资助的物理学前沿中心计划在物理学部，化学理论，模型和计算方法计划在化学部，以及数学和物理科学理事会材料研究部的凝聚态物质和材料理论项目，以及生物科学理事会分子和细胞生物科学部的分子生物物理学项目。