Workshop: Genome Architecture and Dynamics 2019

研讨会:基因组架构与动力学 2019

基本信息

  • 批准号:
    1904161
  • 负责人:
  • 金额:
    $ 22.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-12-15 至 2022-11-30
  • 项目状态:
    已结题

项目摘要

The international Summer School and Workshop: Genome Architecture and Dynamics 2019 will address the physics of genome structure and function. This meeting will bring together 75 researchers and 75 graduate students, drawn from both biological and physical science, to discuss this topic, broadly construed. The meeting will take place in the Bulgarian town of Varna and will last six days. The two initial days will consist of tutorial lectures for the trainees as well as informal gatherings by the senior participants. Afterward there will be four full days of scientific lectures on the state-of-the-art of both experimental techniques and modeling approaches to this extremely exciting topical area. This award will fund the participation of the US scientists in this meeting as well as some overall logistical costs. In recent years, there has been growing excitement about using ideas from physical science to make sense of genome structure in eukaryotic cells. This workshop will be devoted to the basic mechanisms underlying chromatin dynamics and to the methods available to investigate these mechanisms. At the same time, it is clear that basic understanding will go a long way toward being able to understand, and perhaps affect for the better, the role of chromatin in diseases such as cancer and in the aging process.There are a variety of broader impacts that will arise from this meeting. For the training aspects, the organizers will recruit students either directly from the labs of senior participants or through the Physics of Living Systems graduate network. Next. Bulgaria has a long scientific tradition, and a visit to the Bulgarian Academy of Sciences reveals that one of the main focus areas is chromatin structure. The Academy members welcome the opportunity to integrate their research in this area (and their students being trained as part of the research) with the overall international community and have allocated funds for the Bulgarian participants in the meeting. Thus an additional broader impact will be to broaden the international community in a manner which would clearly be helpful to everyone.The structure of the DNA molecule and its associated proteins (commonly referred to as chromatin) is of great interest, both because of the intrinsic problems of how it can be fit into the nucleus and go through various stages as the cell cycle progresses and because it has a major effect on the accessibility of genes and hence couples to cellular differentiation. The excitement has arisen due both to the increasing recognition of the importance of chromatin dynamics for cell function and to the invention of a variety of extremely powerful experimental techniques for determining chromatin properties. This meeting will bring together many of the individuals from around the world leading this field and should have the ability to accelerate focused research in this area for the coming years. The combination of cutting-edge science will enable the organizers to attract a large number of leaders in the field and make this meeting a seminal event. The United States participation in the Summer School and Workshop is supported by the Physics of Living Systems program in the Physics Division, the Molecular Biophysics, the Cellular Dynamics and Function, and the Genetic Mechanisms clusters in the Molecular and Cellular Biosciences Division.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
2019年国际暑期学校和研讨会:基因组结构和动力学将讨论基因组结构和功能的物理学。这次会议将汇集来自生物科学和物理科学的75名研究人员和75名研究生,讨论这一广泛解释的话题。会议将在保加利亚的瓦尔纳镇举行,为期六天。最初的两天将包括为受训人员提供的辅导讲座以及高级参与者的非正式聚会。之后,将有为期四天的科学讲座,介绍这一极其令人兴奋的主题领域的实验技术和建模方法的最新水平。这项奖励将资助美国科学家参加这次会议,以及一些总的后勤费用。近年来,使用物理科学的想法来理解真核细胞的基因组结构越来越令人兴奋。本次研讨会将致力于研究染色质动力学的基本机制以及可用于研究这些机制的方法。与此同时,很明显,基本的了解将大大有助于理解染色质在癌症等疾病和衰老过程中的作用,并可能对其产生更好的影响。这次会议将产生各种更广泛的影响。在培训方面,组织者将直接从高级参与者的实验室或通过生命系统物理学研究生网络招募学生。下一首。保加利亚有着悠久的科学传统,参观保加利亚科学院就会发现,染色质结构是主要的重点领域之一。科学院成员欢迎有机会将他们在这一领域的研究(以及他们的学生作为研究的一部分接受培训)与整个国际社会结合起来,并已为参加会议的保加利亚人拨款。因此,另一个更广泛的影响将是以一种显然对每个人都有帮助的方式扩大国际社会。DNA分子及其相关蛋白质(通常称为染色质)的结构引起了人们的极大兴趣,这既是因为它如何适应细胞核并随着细胞周期的进展经历不同阶段的内在问题,也是因为它对基因的可及性具有重大影响,因此对细胞分化具有重要影响。人们对染色质动力学对细胞功能的重要性的认识日益加深,以及用于确定染色质特性的各种极其强大的实验技术的发明,都引起了人们的兴奋。这次会议将汇集世界各地在这一领域处于领先地位的许多人,并应该有能力在未来几年加快这一领域的重点研究。尖端科学的结合将使主办方能够吸引大量该领域的领导者,并使这次会议成为一次开创性的活动。美国参加暑期学校和研讨会得到了物理部生命系统物理学项目、分子生物物理学、细胞动力学和功能以及分子和细胞生物科学部遗传机制集群的支持。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Jose Onuchic其他文献

The Rop-Dimer: A Folded Protein Living Between Two Alternate Structures
  • DOI:
    10.1016/j.bpj.2008.12.3722
  • 发表时间:
    2009-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Alexander Schug;Yann Gambin;Ashok Deniz;Jose Onuchic
  • 通讯作者:
    Jose Onuchic
Glass-Like Behavior of Magnesium Ions Inside RNA APTamers
  • DOI:
    10.1016/j.bpj.2011.11.3519
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Ryan L. Hayes;Jose Onuchic;Jeff Noel;Karissa Sanbonmatsu;Udayan Mohanty
  • 通讯作者:
    Udayan Mohanty
Protein Knot Forming, Terminal-Through-Loop Threading Events can Occur on the Microsecond (<10) Timescale
  • DOI:
    10.1016/j.bpj.2011.11.2515
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Jeffrey Noel;Joanna Sulkowska;Jose Onuchic
  • 通讯作者:
    Jose Onuchic

Jose Onuchic的其他文献

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{{ truncateString('Jose Onuchic', 18)}}的其他基金

The Energy Landscape for Folding and Function of Biomolecules: From Proteins to Chromatin
生物分子折叠和功能的能量景观:从蛋白质到染色质
  • 批准号:
    2210291
  • 财政年份:
    2022
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Continuing Grant
Collaborative Research: International Physics of Living Systems Graduate Research Network
合作研究:国际生命系统物理学研究生研究网络
  • 批准号:
    2014141
  • 财政年份:
    2021
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Continuing Grant
Center for Theoretical Biological Physics
理论生物物理中心
  • 批准号:
    2019745
  • 财政年份:
    2020
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Cooperative Agreement
Workshop: Theory and Modeling in Molecular Biophysics
研讨会:分子生物物理学理论与建模
  • 批准号:
    1622156
  • 财政年份:
    2016
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Standard Grant
The energy landscape for folding and function of biomolecules: integrating physical models, genetic information and experiments
生物分子折叠和功能的能量景观:整合物理模型、遗传信息和实验
  • 批准号:
    1614101
  • 财政年份:
    2016
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Continuing Grant
Collaborative Research: PoLS Student Research Network
合作研究:PoLS 学生研究网络
  • 批准号:
    1522550
  • 财政年份:
    2015
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Standard Grant
Center for Theoretical Biological Physics - Houston
理论生物物理中心 - 休斯顿
  • 批准号:
    1427654
  • 财政年份:
    2014
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Cooperative Agreement
INSPIRE: Molecular Underpinnings of Bacterial Decision-Making
INSPIRE:细菌决策的分子基础
  • 批准号:
    1241332
  • 财政年份:
    2012
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Standard Grant
Center for Theoretical Biological Physics
理论生物物理中心
  • 批准号:
    1308264
  • 财政年份:
    2012
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Cooperative Agreement
Sharing the Energy Landscape for Folding and Function: from Proteins to Biomolecular Machines.
分享折叠和功能的能量景观:从蛋白质到生物分子机器。
  • 批准号:
    1214457
  • 财政年份:
    2011
  • 资助金额:
    $ 22.54万
  • 项目类别:
    Continuing Grant

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基于Pan-genome技术的沙门氏菌血清型特异性基因挖掘、功能分析及分子鉴定
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    2011
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    58.0 万元
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    面上项目

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