Workshop: Genome Architecture and Dynamics 2019

国际暑期学校和研讨会：基因组结构和动力学2019将讨论基因组结构和功能的物理学。本次会议将汇集75名研究人员和75名研究生，来自生物和物理科学，讨论这个话题，广泛的解释。这次会议将在保加利亚的瓦尔纳镇举行，为期六天。最初的两天将包括培训学员的辅导课以及资深参与者的非正式聚会。之后将有为期四天的科学讲座，介绍这个令人兴奋的主题领域的最新实验技术和建模方法。该奖项将资助美国科学家参加本次会议，并提供一些总体后勤费用。近年来，人们越来越热衷于利用物理科学的思想来理解真核细胞的基因组结构。本次研讨会将致力于染色质动力学的基本机制和研究这些机制的方法。与此同时，很明显，对染色质在癌症等疾病和衰老过程中的作用的基本理解，将在很大程度上有助于理解，或许还会对其产生更好的影响。这次会议将产生各种更广泛的影响。在培训方面，组织者将直接从资深参与者的实验室或通过生命系统物理研究生网络招募学生。下一个。保加利亚有着悠久的科学传统，参观保加利亚科学院就会发现，主要关注的领域之一是染色质结构。学院成员欢迎有机会将他们在这一领域的研究（以及他们的学生作为研究的一部分接受培训）与整个国际社会结合起来，并为参加会议的保加利亚与会者拨出了资金。因此，一个额外的更广泛的影响将是以一种显然对每个人都有帮助的方式扩大国际社会。DNA分子及其相关蛋白质（通常被称为染色质）的结构引起了人们极大的兴趣，因为它的内在问题是如何适应细胞核，并随着细胞周期的进展经历不同的阶段，因为它对基因的可及性有重要影响，因此对细胞分化有重要影响。人们越来越认识到染色质动力学对细胞功能的重要性，并且发明了各种用于确定染色质性质的极其强大的实验技术，这两方面都引起了人们的兴奋。这次会议将汇集来自世界各地的许多在这一领域处于领先地位的人士，他们应该有能力在未来几年加速这一领域的重点研究。尖端科学的结合将使组织者能够吸引大量该领域的领导者，使这次会议成为一次具有开创性的事件。美国对暑期学校和研讨会的参与得到了物理部生命系统物理学项目、分子生物物理学、细胞动力学和功能以及分子和细胞生物科学部遗传机制集群的支持。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The international Summer School and Workshop: Genome Architecture and Dynamics 2019 will address the physics of genome structure and function. This meeting will bring together 75 researchers and 75 graduate students, drawn from both biological and physical science, to discuss this topic, broadly construed. The meeting will take place in the Bulgarian town of Varna and will last six days. The two initial days will consist of tutorial lectures for the trainees as well as informal gatherings by the senior participants. Afterward there will be four full days of scientific lectures on the state-of-the-art of both experimental techniques and modeling approaches to this extremely exciting topical area. This award will fund the participation of the US scientists in this meeting as well as some overall logistical costs. In recent years, there has been growing excitement about using ideas from physical science to make sense of genome structure in eukaryotic cells. This workshop will be devoted to the basic mechanisms underlying chromatin dynamics and to the methods available to investigate these mechanisms. At the same time, it is clear that basic understanding will go a long way toward being able to understand, and perhaps affect for the better, the role of chromatin in diseases such as cancer and in the aging process.There are a variety of broader impacts that will arise from this meeting. For the training aspects, the organizers will recruit students either directly from the labs of senior participants or through the Physics of Living Systems graduate network. Next. Bulgaria has a long scientific tradition, and a visit to the Bulgarian Academy of Sciences reveals that one of the main focus areas is chromatin structure. The Academy members welcome the opportunity to integrate their research in this area (and their students being trained as part of the research) with the overall international community and have allocated funds for the Bulgarian participants in the meeting. Thus an additional broader impact will be to broaden the international community in a manner which would clearly be helpful to everyone.The structure of the DNA molecule and its associated proteins (commonly referred to as chromatin) is of great interest, both because of the intrinsic problems of how it can be fit into the nucleus and go through various stages as the cell cycle progresses and because it has a major effect on the accessibility of genes and hence couples to cellular differentiation. The excitement has arisen due both to the increasing recognition of the importance of chromatin dynamics for cell function and to the invention of a variety of extremely powerful experimental techniques for determining chromatin properties. This meeting will bring together many of the individuals from around the world leading this field and should have the ability to accelerate focused research in this area for the coming years. The combination of cutting-edge science will enable the organizers to attract a large number of leaders in the field and make this meeting a seminal event. The United States participation in the Summer School and Workshop is supported by the Physics of Living Systems program in the Physics Division, the Molecular Biophysics, the Cellular Dynamics and Function, and the Genetic Mechanisms clusters in the Molecular and Cellular Biosciences Division.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.