Workshop: Genome Architecture and Dynamics 2019

国际暑期学校和研讨会：基因组结构和动力学2019将解决基因组结构和功能的物理学问题。这次会议将汇集75名研究人员和75名研究生，来自生物和物理科学，讨论这个话题，广泛解释。会议将在保加利亚的瓦尔纳镇举行，为期6天。最初的两天将包括为受训人员举办辅导讲座以及高级学员举行非正式聚会。之后，将有四个完整的科学讲座的国家的最先进的实验技术和建模方法，这一极其令人兴奋的专题领域。该奖项将资助美国科学家参加这次会议以及一些总体后勤费用。近年来，人们越来越热衷于利用物理科学的思想来理解真核细胞的基因组结构。 本次研讨会将致力于染色质动力学的基本机制，并提供调查这些机制的方法。与此同时，很明显，基本的了解将有助于理解染色质在癌症等疾病和衰老过程中的作用，也许会产生更好的影响。这次会议将产生各种更广泛的影响。对于培训方面，组织者将直接从高级参与者的实验室或通过生命系统物理学研究生网络招募学生。 下一个保加利亚有着悠久的科学传统，参观保加利亚科学院可以发现，染色质结构是主要关注的领域之一。学院成员欢迎有机会将他们在这一领域的研究（以及作为研究的一部分而接受培训的学生）与整个国际社会结合起来，并为保加利亚与会者拨出了资金。 因此，另一个更广泛的影响将是以一种显然对每个人都有帮助的方式扩大国际社会。（通常称为染色质）是非常感兴趣的，这既是因为它如何适应细胞核并随着细胞周期的进展而经历各个阶段的内在问题，也是因为它对细胞周期有重大影响。基因的可接近性，因此与细胞分化相结合。由于越来越多的人认识到染色质动力学对细胞功能的重要性，以及发明了各种非常强大的实验技术来确定染色质特性，因此出现了令人兴奋的现象。这次会议将汇集来自世界各地的许多领导这一领域的个人，并应该有能力在未来几年加速这一领域的重点研究。尖端科学的结合将使组织者能够吸引该领域的大量领导者，并使这次会议成为一个开创性的事件。美国参加暑期学校和讲习班得到了物理系生命系统物理学方案、分子生物物理学、细胞动力学和功能、该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查进行评估，被认为值得支持的搜索.

The international Summer School and Workshop: Genome Architecture and Dynamics 2019 will address the physics of genome structure and function. This meeting will bring together 75 researchers and 75 graduate students, drawn from both biological and physical science, to discuss this topic, broadly construed. The meeting will take place in the Bulgarian town of Varna and will last six days. The two initial days will consist of tutorial lectures for the trainees as well as informal gatherings by the senior participants. Afterward there will be four full days of scientific lectures on the state-of-the-art of both experimental techniques and modeling approaches to this extremely exciting topical area. This award will fund the participation of the US scientists in this meeting as well as some overall logistical costs. In recent years, there has been growing excitement about using ideas from physical science to make sense of genome structure in eukaryotic cells. This workshop will be devoted to the basic mechanisms underlying chromatin dynamics and to the methods available to investigate these mechanisms. At the same time, it is clear that basic understanding will go a long way toward being able to understand, and perhaps affect for the better, the role of chromatin in diseases such as cancer and in the aging process.There are a variety of broader impacts that will arise from this meeting. For the training aspects, the organizers will recruit students either directly from the labs of senior participants or through the Physics of Living Systems graduate network. Next. Bulgaria has a long scientific tradition, and a visit to the Bulgarian Academy of Sciences reveals that one of the main focus areas is chromatin structure. The Academy members welcome the opportunity to integrate their research in this area (and their students being trained as part of the research) with the overall international community and have allocated funds for the Bulgarian participants in the meeting. Thus an additional broader impact will be to broaden the international community in a manner which would clearly be helpful to everyone.The structure of the DNA molecule and its associated proteins (commonly referred to as chromatin) is of great interest, both because of the intrinsic problems of how it can be fit into the nucleus and go through various stages as the cell cycle progresses and because it has a major effect on the accessibility of genes and hence couples to cellular differentiation. The excitement has arisen due both to the increasing recognition of the importance of chromatin dynamics for cell function and to the invention of a variety of extremely powerful experimental techniques for determining chromatin properties. This meeting will bring together many of the individuals from around the world leading this field and should have the ability to accelerate focused research in this area for the coming years. The combination of cutting-edge science will enable the organizers to attract a large number of leaders in the field and make this meeting a seminal event. The United States participation in the Summer School and Workshop is supported by the Physics of Living Systems program in the Physics Division, the Molecular Biophysics, the Cellular Dynamics and Function, and the Genetic Mechanisms clusters in the Molecular and Cellular Biosciences Division.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.