MRI: Development of a Field-deployable Low-pressure Gas Chromatograph with Chemical Ionization Detection

MRI：开发具有化学电离检测功能的现场部署低压气相色谱仪

• 批准号: 1428482
• 负责人: Paul Wennberg
• 金额: $ 51.82万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1428482&HistoricalAwards=false
• 关键词: MRI; Development; Field; deployable; Low

Many of the more oxidized compounds found in the atmosphere, in gas and aerosol phases, represent a challenge for chemists to identify and measure due to their high reactivity, and propensity to breakdown or combine with other chemical species and surfaces. They may have the same molecular mass and formula. CalTech atmospheric chemists will adapt a gas chromatography mass spectrometer (GC/MS) with a highly sensitive detection scheme for multifunctional organic compounds using a chemical-ionization clustering method developed at Caltech. The project builds off an existing testbed where researchers have demonstrated high transmission of otherwise labile (fragile) organic peroxides, hydroxynitrates, and hydroxyl-ketones through a standard chromatographic column, which separates them prior to their measurement by a mass spec. The development of this methodology involves collaboration of a team of scientists, instrument builders, machinists, and software engineers to create a new instrument. It is important to maintain the capability to build such instruments in an academic institution. This project involves the training of a graduate student in instrumentation science, providing a platform for training the next generation of analytical chemists.

在大气中发现的许多氧化程度更高的化合物，以气相和气溶胶相存在，由于其高反应性以及分解或与其他化学物质和表面联合收割机结合的倾向，对化学家来说是一个识别和测量的挑战。它们可以具有相同的分子量和分子式。加州理工学院的大气化学家将采用一种气相色谱质谱仪（GC/MS），采用加州理工学院开发的化学电离聚类方法，对多功能有机化合物进行高灵敏度检测。该项目建立在现有的测试平台上，研究人员已经证明了通过标准色谱柱对不稳定（易碎）的有机过氧化物，羟基硝酸盐和羟基酮的高传输，该色谱柱在质谱仪测量之前将其分离。该方法的开发涉及科学家，仪器制造商，机械师和软件工程师团队的合作，以创建新仪器。重要的是要保持在学术机构建立这种工具的能力。该项目涉及仪器科学研究生的培训，为培养下一代分析化学家提供了一个平台。