Conference: FASEB Mechanisms of mRNA decay; Big Sky, Montana; July 6 - July 11, 2014

会议：FASEB mRNA 衰减机制；

• 批准号: 1441935
• 负责人: Ambro van Hoof
• 金额: $ 0.7万
• 依托单位: Federation of Amer Societies For Exper Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1441935&HistoricalAwards=false
• 关键词: Conference; FASEB; Mechanisms; mRNA; decay

The transfer of information from the genomic DNA to messenger RNA (mRNA) during the process of gene expression provides an important way to control the genes responsible for specific biological processes. Understanding how these processes work normally allows us a means to comprehend how they can change when organisms face alterations in their environment or evolve. Recently, it is clear that mRNA degradation is also an important means for regulating gene expression. Thus, gaining a complete understanding of mRNA degradation mechanisms and its regulation are of critical interest. More recently, the spectacular use of interfering RNA to experimentally degrade specific mRNAs has expanded the applications of understanding mRNA decay mechanisms beyond any expectations. The Federation American Societies for Experimental Biology (FASEB) meeting on mechanisms of mRNA decay from July 6th to 11th 2014 in Big Sky, Montana brings together the leading experts in mRNA decay in animal, fungal, plant, viral, bacterial, and archaeal systems. One of the chief benefits of this 5-day meeting is that it brings together experts who study mRNA degradation using various approaches and organisms, providing the opportunity for cross-fertilization and allowing many parallels between mRNA degradation in pro- and eukaryotes to become evident. Both the size and planned organization of the meeting support junior investigators in the field of RNA degradation. With only 100-150 attendees all being housed in the same venue, and with talks and posters only in the morning and evening, there is expected to be ample time and opportunity for informal interactions between junior and senior attendees. Some of the oral presenters will be selected from submitted abstracts to give junior investigators the opportunity to present their work for critical viewing by the community. In addition, poster sessions will allow others to display their work to stimulate conversations and feedback. There will also be meet-the-expert sessions and opportunities to interact with them more informally during the meeting. All of these aspects are viewed as positive enhancements of the professional development of junior investigators in this field.The requested funds will be used to reimburse seven speakers for about half their costs some selected from submitted abstracts. Priority for this support will be students, post-docs, early-career independent investigators, and members of underrepresented groups who are members of the US scientific community.

在基因表达过程中，基因组DNA向信使RNA（mRNA）的信息传递为控制负责特定生物过程的基因提供了重要途径。 了解这些过程通常是如何工作的，使我们能够理解当生物体面临环境变化或进化时，它们是如何变化的。近年来，研究表明mRNA降解也是调控基因表达的重要手段。 因此，获得mRNA降解机制及其调控的完整理解是至关重要的。最近，干扰RNA在实验上降解特定mRNA的惊人应用已经超出了任何预期，扩大了理解mRNA衰变机制的应用。美国实验生物学联合会（FASEB）于2014年7月6日至11日在蒙大拿州大天空举行的mRNA衰变机制会议汇集了动物，真菌，植物，病毒，细菌和古细菌系统中mRNA衰变的领先专家。这次为期5天的会议的主要好处之一是，它汇集了使用各种方法和生物体研究mRNA降解的专家，为交叉受精提供了机会，并使原核生物和真核生物的mRNA降解之间的许多相似之处变得明显。 会议的规模和计划组织都支持RNA降解领域的初级研究人员。 由于只有100-150名与会者都被安置在同一个场地，并与会谈和海报只在上午和晚上，预计将有足够的时间和机会，初级和高级与会者之间的非正式互动。 一些口头报告将从提交的摘要中选出，以使初级研究人员有机会向社区介绍他们的工作。 此外，海报会议将允许其他人展示他们的工作，以刺激对话和反馈。 会议期间还将举行专家会议，并有机会与他们进行非正式的互动。 所有这些方面都被认为是对初级调查员在这一领域的专业发展的积极促进，所要求的资金将用于偿还七名发言者大约一半的费用，其中一些人是从提交的摘要中挑选出来的。这项支持的优先对象将是学生、博士后、早期职业独立调查人员以及美国科学界代表性不足的群体成员。