I-Corps: Cortisense - A point of care sensor for measurement of stress

I-Corps：Cortisense - 用于测量压力的护理点传感器

• 批准号: 1444327
• 负责人: Shekhar Bhansali
• 金额: $ 5万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1444327&HistoricalAwards=false
• 关键词: Corps; Cortisense; point; care; sensor

Currently, stress-related disorders such as post-traumatic stress disorder (PTSD) are diagnosed and monitored clinically. A diagnostic aid that can provide a quantitative correlation for both diagnosis and efficacy of treatment is sorely needed. This team has developed a technology that will facilitate point-of-care monitoring of cortisol, the key stress biomarker, by measuring its levels in body fluids. The proposed technology promises to advance the level of health care for military patients with PTSD. It also has the potential to reach other market segments, such as farm workers and fire fighters, who might also benefit from alternative treatments to stress-induced conditions based on the near real-time measurement of cortisol concentrations in saliva.The proposed cortisol sensing technology is a transformative technology that enables monitoring of stress levels non-invasively using a nanoengineered biochip and a handheld measurement unit. The nanoengineered biochip is both low cost and disposable. The proposed technology will enable quantitative correlations to observed medical conditions and help improve the efficacy of treatment through monitoring of the stress hormone cortisol as the patient continues to be in the care of the doctors. This portable sensor accurately measures cortisol levels, a known indicator of stress in 30 minutes. The accuracy of the sensor would lead to a new class of tests that would provide quantitative information for difficult to diagnose diseases like PTSD, while significantly reducing the time to diagnosis.

目前，与压力有关的疾病，如创伤后应激障碍（PTSD）是临床诊断和监测。迫切需要一种能够为诊断和治疗效果提供定量相关性的诊断辅助工具。该团队已经开发出一种技术，通过测量体液中皮质醇的水平，有助于对皮质醇（关键的压力生物标志物）进行即时监测。这项技术有望提高军队创伤后应激障碍患者的医疗水平。它也有可能达到其他细分市场，如农场工人和消防队员，谁也可能受益于替代治疗的压力引起的条件的基础上，近实时测量唾液中的皮质醇浓度。拟议的皮质醇传感技术是一种变革性的技术，使监测压力水平的非侵入性使用纳米工程生物芯片和手持测量单元。纳米工程生物芯片是低成本和一次性的。拟议的技术将使定量相关性，以观察到的医疗条件，并有助于提高治疗的效果，通过监测应激激素皮质醇，因为病人继续在医生的照顾。 这款便携式传感器可以在30分钟内准确测量皮质醇水平，这是一种已知的压力指标。 传感器的准确性将导致一类新的测试，这些测试将为难以诊断的疾病（如PTSD）提供定量信息，同时显着缩短诊断时间。