I-Corps: Volatile Organic Compound Sensors using Conducting Polymer and Nanocomposite Blends deposited by Resonant Infrared, Matrix-Assisted Pulsed Laser Evaporation

I-Corps：使用通过共振红外、基质辅助脉冲激光蒸发沉积的导电聚合物和纳米复合材料混合物制成的挥发性有机化合物传感器

• 批准号: 1450511
• 负责人: Adrienne Stiff-Roberts
• 金额: $ 5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1450511&HistoricalAwards=false
• 关键词: Corps; Volatile; Organic; Compound; Sensors

There is a large number of diabetics for whom a simple breath test to determine glucose abnormalities would be deemed superior to the current standard blood test. Development of a non-invasive method to monitor blood glucose that mirrors the accuracy of the painful blood test would revolutionize not only the lives of diabetics, but also the lives of the physicians who monitor their health. The painful blood test that is currently the standard monitoring method is potentially expensive, and it also deters regular monitoring of glucose - often with dangerous outcomes. It is especially dangerous for diabetics who have hypoglycemia unawareness, in which case, only the glucose test will alert the person to the dangerously low blood sugar levels that can lead to coma or even death.This work will develop gas sensors for detection of volatile organic compounds (VOCs) in exhaled human breath that act as biomarkers of internal bodily processes, specifically those processes existing uniquely in diabetes patients. The gas sensors comprise organic thin-films deposited by resonant infrared, matrix-assisted pulsed laser evaporation (RIR-MAPLE). RIR-MAPLE provides vastly increased processability and control over a large range of functional organic materials for which few methods exist to effectively fabricate films with nanoscale features.

有大量的糖尿病患者，对他们来说，简单的呼气测试来确定血糖异常将被认为优于目前的标准血液测试。开发一种非侵入性的血糖监测方法，反映痛苦的血液测试的准确性，不仅将彻底改变糖尿病患者的生活，也将改变监测他们健康的医生的生活。目前作为标准监测方法的痛苦血液测试潜在地昂贵，而且它还阻碍了对血糖的定期监测--通常会产生危险的后果。对于没有意识到低血糖的糖尿病患者来说，这尤其危险，在这种情况下，只有血糖测试会提醒患者注意危险的低血糖水平，这可能会导致昏迷甚至死亡。这项工作将开发气体传感器，用于检测呼气中的挥发性有机化合物(VOCs)，作为体内过程的生物标志物，特别是糖尿病患者特有的那些过程。气体传感器包括由共振红外、基质辅助脉冲激光蒸发(RIR-Maple)沉积的有机薄膜。RIR-Maple极大地提高了可加工性和对多种功能有机材料的控制，目前几乎没有方法可以有效地制备具有纳米级特征的薄膜。