CAREER: Cyclodextrin-Promoted Energy Transfer: From Fundamental Molecular Interactions to Complex System Performance

职业：环糊精促进的能量转移：从基本分子相互作用到复杂系统性能

• 批准号: 1453483
• 负责人: Mindy Levine
• 金额: $ 65万
• 依托单位: University of Rhode Island
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1453483&HistoricalAwards=false
• 关键词: CAREER; Cyclodextrin; Promoted; Energy; Transfer

Dr. Mindy Levine of the University of Rhode Island studies how molecules interact with each other when they are in close proximity, but are not physically contacted, and investigates how such interactions affect the transfer of energy from one molecule to another. This knowledge is fundamentally important and is useful for the design and optimization of systems for sensitive detection of analytes (e.g., sensing of metabolites in biological fluids) or environmental remediation (e.g., extraction of toxic substances in water from oil spills). Additional broader impacts of this project include: 1) training of graduate and undergraduate students in interdisciplinary research; 2) education of high school girls in Rhode Island about the importance of science through the outreach programs on the "Sugar Science Day"; 3) education of the general public by sharing the videos of "Sugar Science Day" at YouTube; and 4) research opportunities for high school girls through paid science internships.With this award from the Macromolecular, Supramolecular and Nanochemistry Program in the Chemistry Division, Dr. Levine's research group studies fluorescence energy transfer from a variety of aromatic energy donors to small molecule fluorophore acceptors, when both the donor and acceptor are held in close proximity by cyclodextrins or cyclodextrin derivatives in solution. Isothermal calorimetry, 2-D NMR analyses, and X-ray crystallography are employed to determine the binding affinities and geometries of the donors and acceptors in the ternary complexes. To enable the development of applications requiring solid-state immobilization of cyclodextrins, the researchers further investigate the effect of surface immobilization of cyclodextrins on binding affinities and fluorescence energy transfer. This research also aims to generate a cyclodextrin-based system for the extraction and detection of polyaromatic hydrocarbons from complex oils.

罗得岛大学的Mindy Levine博士研究了分子在接近但没有物理接触时如何相互作用，并研究了这种相互作用如何影响能量从一个分子转移到另一个分子。 该知识是基本重要的并且对于用于分析物的灵敏检测的系统的设计和优化是有用的（例如，感测生物流体中的代谢物）或环境补救（例如，从溢油中提取水中的有毒物质）。 该项目的其他更广泛的影响包括：1）培训研究生和本科生进行跨学科研究; 2）通过“糖科学日”的外联方案教育罗得岛的高中女生认识科学的重要性; 3）通过在YouTube上分享“糖科学日”的视频教育公众;和4）通过带薪科学实习为高中女生提供研究机会。凭借化学部大分子，超分子和纳米化学计划的这一奖项，Levine博士的研究小组研究了从各种芳香族能量供体到小分子荧光团受体的荧光能量转移，当供体和受体通过溶液中的环糊精或环糊精衍生物保持紧密接近时。 等温量热法，2-D NMR分析，和X-射线晶体学被用来确定在三元复合物中的供体和受体的结合亲和力和几何形状。 为了开发需要固态固定化环糊精的应用，研究人员进一步研究了表面固定化环糊精对结合亲和力和荧光能量转移的影响。 本研究还旨在生成用于从复杂油中提取和检测多环芳烃的基于环糊精的系统。