权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

CAREER: Biofluid Dynamics of the Human Breast: Characterization and Fluid-Structure Interaction

职业：人类乳房的生物流体动力学：表征和流固相互作用

基本信息

批准号：
1454334
负责人：
Fatemeh Hassanipour
金额：
$ 50.32万
依托单位：
University of Texas at Dallas
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1454334&HistoricalAwards=false
关键词：
CAREER Biofluid Dynamics Human Breast

项目摘要

1454334HassanipourThe goal of this CAREER proposal is to study lactation in the human breast from a fluid dynamics point of view, considering the flow of milk as flow through a porous medium with flexible structure. Despite the scientific importance and impact on public health, bio-transport processes in the human breast have not been comprehensively studied, and are currently not well-understood. This is the white space that the current proposal aims to cover, with potential impact on the lives of millions of people. Success of the project can enable biomedical devise design and diagnosis of health conditions related to the female breast. This project has the potential for high rewards, since it can open up a completely new area of research. The societal and economic impact of understanding fundamentally the fluid-structure interaction in the human breast can be very significant, ranging from effective drug delivery to health condition diagnosis and the design of medical devises resolving lactation difficulties. The PI is proposing to use state-of-the-art experiments and simulations to understand the bio-transport behavior of the ductal system of the human breast. Advanced imaging and 3D printing techniques are going to be used to obtain realistic images of the pore structure within human breasts and then to manufacture prototypes for laboratory and computational investigation of the flow. The breast-infant interaction and the boundary effects of infant suckling will also be investigated. The proposed research activities are further integrated with an educational component including course development, and K-12 outreach activities that are a continuation of PI's past work with high-school students.

这份职业提案的目标是从流体动力学的角度研究人类乳房中的哺乳，将乳汁的流动视为通过具有灵活结构的多孔介质的流动。尽管有科学上的重要性和对公共健康的影响，但人类乳房中的生物转运过程尚未得到全面研究，目前也没有得到很好的了解。这是当前提案旨在覆盖的空白区域，可能会对数百万人的生活产生影响。该项目的成功可以使生物医学设计和诊断与女性乳房有关的健康状况成为可能。这个项目有可能获得高额回报，因为它可以开辟一个全新的研究领域。从根本上了解人类乳房内流体-结构相互作用的社会和经济影响非常显著，从有效的药物输送到健康状况诊断和解决哺乳困难的医疗器械的设计。PI建议使用最先进的实验和模拟来了解人类乳房导管系统的生物运输行为。先进的成像和3D打印技术将被用来获得人体乳房内毛孔结构的逼真图像，然后制造用于流动的实验室和计算研究的原型。还将研究母乳与婴儿的相互作用和婴儿哺乳的边界效应。拟议的研究活动进一步与教育部分相结合，包括课程开发和K-12外联活动，这些活动是PI过去与高中生的工作的延续。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Lactation in the Human Breast From a Fluid Dynamics Point of View

从流体动力学的角度看人类乳房的哺乳

DOI：
10.1115/1.4034995
发表时间：
2017
期刊：
Journal of Biomechanical Engineering
影响因子：
0
作者：
Negin Mortazavi, S.;Geddes, Donna;Hassanipour, Fatemeh
通讯作者：
Hassanipour, Fatemeh

Fluid-structure interaction modeling of lactating breast: Newtonian vs. non-Newtonian milk

哺乳期乳房的流固耦合模型：牛顿奶与非牛顿奶

DOI：
10.1016/j.jbiomech.2021.110500
发表时间：
2021
期刊：
Journal of Biomechanics
影响因子：
2.4
作者：
Azarnoosh, Jamasp;Hassanipour, Fatemeh
通讯作者：
Hassanipour, Fatemeh

A mathematical modeling toolbox for ion channels and transporters across cell membranes

DOI：
10.1016/j.ijheatmasstransfer.2021.121423
发表时间：
2021-06-09
期刊：
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
影响因子：
5.2
作者：
Zaheri，Shadi;Hassanipour，Fatemeh
通讯作者：
Hassanipour，Fatemeh

A Clinical Experiment on Infant Applied Pressures During Breastfeeding

母乳喂养期间婴儿施加压力的临床实验

DOI：
10.1115/imece2018-87674
发表时间：
2018
期刊：
ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers
影响因子：
0
作者：
Jiang, Lin;Alatalo, Diana L.;Geddes, Donna T.;Hassanipour, Fatemeh
通讯作者：
Hassanipour, Fatemeh

A comprehensive approach to the mathematical modeling of mass transport in biological systems: Fundamental concepts and models