CAREER: Biofluid Dynamics of the Human Breast: Characterization and Fluid-Structure Interaction

职业：人类乳房的生物流体动力学：表征和流固相互作用

基本信息

批准号：
1454334
负责人：
Fatemeh Hassanipour
金额：
$ 50.32万
依托单位：
University of Texas at Dallas
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1454334&HistoricalAwards=false
关键词：
CAREER Biofluid Dynamics Human Breast

项目摘要

1454334HassanipourThe goal of this CAREER proposal is to study lactation in the human breast from a fluid dynamics point of view, considering the flow of milk as flow through a porous medium with flexible structure. Despite the scientific importance and impact on public health, bio-transport processes in the human breast have not been comprehensively studied, and are currently not well-understood. This is the white space that the current proposal aims to cover, with potential impact on the lives of millions of people. Success of the project can enable biomedical devise design and diagnosis of health conditions related to the female breast. This project has the potential for high rewards, since it can open up a completely new area of research. The societal and economic impact of understanding fundamentally the fluid-structure interaction in the human breast can be very significant, ranging from effective drug delivery to health condition diagnosis and the design of medical devises resolving lactation difficulties. The PI is proposing to use state-of-the-art experiments and simulations to understand the bio-transport behavior of the ductal system of the human breast. Advanced imaging and 3D printing techniques are going to be used to obtain realistic images of the pore structure within human breasts and then to manufacture prototypes for laboratory and computational investigation of the flow. The breast-infant interaction and the boundary effects of infant suckling will also be investigated. The proposed research activities are further integrated with an educational component including course development, and K-12 outreach activities that are a continuation of PI's past work with high-school students.

1454334HASSANIPOUR这个职业建议的目标是从流体动力学的角度研究人乳房中的泌乳，考虑到牛奶的流动是通过具有柔性结构的多孔培养基流动的。尽管对公共卫生具有科学的重要性和影响，但人类乳房中的生物传播过程尚未得到全面研究，目前尚未得到充分理解。这是当前提案旨在涵盖的空白，并可能影响数百万人的生活。该项目的成功可以使生物医学设计和诊断与女性乳房有关的健康状况。该项目具有高奖励的潜力，因为它可以打开一个全新的研究领域。从根本上了解人类乳房中流体结构相互作用的社会和经济影响可能非常重要，从有效的药物递送到健康状况诊断以及医疗设计的设计解决了解决泌乳困难。 PI建议使用最先进的实验和模拟来了解人乳腺导管系统的生物传输行为。先进的成像和3D打印技术将用于获得人类乳房内孔结构的逼真图像，然后制造原型用于实验室和计算的流量。还将研究婴儿哺乳的乳房相互作用和边界影响。拟议的研究活动进一步与包括课程开发在内的教育组成部分以及K-12外展活动，这是Pi过去与高中生的过去合作的延续。