CAREER: Biofluid Dynamics of the Human Breast: Characterization and Fluid-Structure Interaction

1454334 Hassanipour本CAREER提案的目标是从流体动力学的角度研究人类乳房的泌乳，将乳汁的流动视为通过具有柔性结构的多孔介质的流动。尽管在科学上的重要性和对公共卫生的影响，在人类乳房的生物运输过程还没有得到全面的研究，目前还没有得到很好的理解。这是当前提案旨在覆盖的白色空间，可能对数百万人的生活产生影响。该项目的成功可以使生物医学设计和诊断与女性乳房有关的健康状况成为可能。这个项目有可能获得高额回报，因为它可以开辟一个全新的研究领域。从根本上理解人类乳房中流体-结构相互作用的社会和经济影响可能非常重要，从有效的药物输送到健康状况诊断和解决哺乳困难的医疗器械设计。PI建议使用最先进的实验和模拟来了解人类乳腺导管系统的生物运输行为。先进的成像和3D打印技术将用于获得人类乳房内孔隙结构的逼真图像，然后制造原型，用于实验室和计算研究。同时也将研究母乳与婴儿的相互作用和婴儿吮吸的边界效应。拟议的研究活动进一步整合了教育部分，包括课程开发和K-12外展活动，这些活动是PI过去与高中学生合作的延续。

1454334HassanipourThe goal of this CAREER proposal is to study lactation in the human breast from a fluid dynamics point of view, considering the flow of milk as flow through a porous medium with flexible structure. Despite the scientific importance and impact on public health, bio-transport processes in the human breast have not been comprehensively studied, and are currently not well-understood. This is the white space that the current proposal aims to cover, with potential impact on the lives of millions of people. Success of the project can enable biomedical devise design and diagnosis of health conditions related to the female breast. This project has the potential for high rewards, since it can open up a completely new area of research. The societal and economic impact of understanding fundamentally the fluid-structure interaction in the human breast can be very significant, ranging from effective drug delivery to health condition diagnosis and the design of medical devises resolving lactation difficulties. The PI is proposing to use state-of-the-art experiments and simulations to understand the bio-transport behavior of the ductal system of the human breast. Advanced imaging and 3D printing techniques are going to be used to obtain realistic images of the pore structure within human breasts and then to manufacture prototypes for laboratory and computational investigation of the flow. The breast-infant interaction and the boundary effects of infant suckling will also be investigated. The proposed research activities are further integrated with an educational component including course development, and K-12 outreach activities that are a continuation of PI's past work with high-school students.