Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
批准号:
10611826
负责人:
JOEL H KRAMER
金额:
$108.08万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-29 至 2026-07-31
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
Small vessel cerebrovascular disease is common in the elderly and is a well-known contributor to cognitive decline. A major gap in the field, however, is the ongoing need for reliable and reproducible biologic markers of vascular disease suitable for early detection, disease monitoring, and measuring treatment efficacy. The overarching goal of this proposal is to clinically validate novel neuroimaging and fluid-based biomarkers of a cerebrovascular disease selected by the NINDs and developed during the first five years of the MarkVCID consortium. We propose to longitudinally follow a cohort of 200 diverse, older subjects who present with a range of cerebrovascular burdens and cognitive complaints, and functional decline. Our aims are to validate the MarkVCID biomarkers and address possible interactions between these biomarkers and Alzheimer’s disease pathophysiology. Accomplishing these goals will improve the early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects and provide better targets and outcome metrics for clinical trials.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Core B: Clinical Core
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批准号:10431780
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项目类别:
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资助金额:$184.36万
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财政年份:2019
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负责人:JOEL H KRAMER
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依托单位:
Core B: Clinical Core
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批准号:10647904
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项目类别:
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资助金额:$154.06万
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财政年份:2019
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负责人:JOEL H KRAMER
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依托单位:
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
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批准号:10369292
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项目类别:
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资助金额:$254.76万
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财政年份:2016
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依托单位:
Effects of chronic inflammation on brain structure and function
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批准号:9217542
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项目类别:
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资助金额:$59.44万
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财政年份:2015
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负责人:JOEL H KRAMER
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依托单位:
Effects of chronic inflammation on brain structure and function
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批准号:9052104
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项目类别:
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资助金额:$46.69万
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财政年份:2015
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负责人:JOEL H KRAMER
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依托单位:
Effects of chronic inflammation on brain structure and function
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批准号:9415443
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项目类别:
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资助金额:$59.42万
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财政年份:2015
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负责人:JOEL H KRAMER
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依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
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批准号:8171130
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项目类别:
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资助金额:$0.91万
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财政年份:2010
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:8288767
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项目类别:
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资助金额:$54.46万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Biological predictors of brain aging trajectories
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批准号:10052959
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项目类别:
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资助金额:$512.71万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease
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批准号:10390159
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项目类别:
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资助金额:$16.99万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:8466268
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项目类别:
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资助金额:$48.37万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:7857945
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项目类别:
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资助金额:$48.25万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
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批准号:7955751
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项目类别:
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资助金额:$0.34万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:7662589
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项目类别:
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资助金额:$48.44万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:8074919
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项目类别:
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资助金额:$42.35万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
Mechanisms of Executive Decline in Normal Aging
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批准号:8296140
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项目类别:
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资助金额:$4.44万
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财政年份:2009
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负责人:JOEL H KRAMER
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依托单位:
ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA
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批准号:7724481
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项目类别:
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资助金额:$0.26万
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财政年份:2008
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负责人:JOEL H KRAMER
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依托单位:
Attention and Executive Functioning in FTD
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批准号:6943859
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项目类别:
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资助金额:$22.85万
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财政年份:2004
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负责人:JOEL H KRAMER
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依托单位:
Cognitive and Behavioral Control in FTD
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批准号:8106877
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项目类别:
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资助金额:$28.57万
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财政年份:2004
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负责人:JOEL H KRAMER
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依托单位:
Decision-Making in Genetic FTD
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批准号:9319942
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项目类别:
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资助金额:$63.15万
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财政年份:2004
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负责人:JOEL H KRAMER
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依托单位:
国内基金
海外基金
非小细胞肺癌Biomarker的Imaging MS研究新方法
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批准号:30672394
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项目类别:面上项目
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资助金额:30.0万元
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批准年份:2006
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负责人:陆豪杰
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依托单位: