Cell recruitment in retinal angiogenesis

视网膜血管生成中的细胞募集

• 批准号: 21910298
• 负责人: Professorin Dr. Antonia Joussen
• 金额: --
• 依托单位: Klinik für Augenheilkunde (CBF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/21910298?language=en
• 关键词: Cell; recruitment; retinal; angiogenesis

The most severe pathology of proliferative diabetic retinopathy is the formation of retinal neovascularization. This proposal addresses the role of the recruitment of endothelial precursors and macrophages to sites of retinal neovascularization. We will assess the contribution of pluripotent bone marrow precursor cells to retinal angiogenesis and identify the specific stem cell population recruited into the vessel walls of the retina. In this, endothelial precursor cells will be investigated as well as myeloid lineage cells. Finally, the role of growth factors and adhesion molecues in stem cell recruitment will be assessed.

增殖性糖尿病视网膜病变最严重的病理是视网膜新生血管的形成。这一建议解决了内皮前体细胞和巨噬细胞募集到视网膜新生血管的位置的作用。我们将评估多能性骨髓前体细胞对视网膜血管生成的贡献，并确定招募到视网膜血管壁的特定干细胞群。在这方面，内皮前体细胞将被调查以及髓系细胞。最后，将评估生长因子和粘附分子在干细胞募集中的作用。