RUI: Novel Fe Catalysts for Alcohol Amine Coupling Reaction to Imine

RUI：用于醇胺偶联反应生成亚胺的新型铁催化剂

• 批准号: 1465051
• 负责人: Keying Ding
• 金额: $ 14.32万
• 依托单位: Middle Tennessee State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465051&HistoricalAwards=false
• 关键词: RUI; Novel; Fe; Catalysts; Alcohol

With this award, the Chemical Catalysis Program of the Chemistry Division is funding Professor Keying Ding from Middle Tennessee State University to develop a novel types of earth-abundant catalysts for a useful coupling reaction. The target chemical structures, imines, represent a very important class of compounds with applications in the chemical, pharmaceutical and biological sectors. Currently, such coupling reactions employ precious metal catalysts that are expensive,sometimes toxic, and limited in supply. Thus, the most common approaches today pose economic and often environmental challenges. Developing catalytic processes for such reactions with earth-abundant metal systems is compatible with sustainable chemistry goals. Success here would also likely capture the attention of pharmaceutical process groups and industrial chemists. The broader impacts of the research include training opportunities and hands-on research experiences for undergraduate students, master-level researchers and high school students, including those from underrepresented groups and low-income backgrounds.In this project, Professor Keying Ding is designing, synthesizing and characterizing new types of ligands and their respective defined iron complexes featuring "metal-ligand cooperativities." Professor Ding is studying their catalytic reactivity toward alcohol-amine couplings under mild conditions. In the currently studied system, the ligands not only serve as metal binding sites, but also directly participate in chemical bond activations. The project is exploring the optimal reaction conditions and the substrate scope for alcohols and amines. Important reaction intermediates and catalytic mechanisms are being investigated by combined experimental and theoretical studies, which will enrich fundamental understanding of non-precious metal catalysis for such transformations and will provide new insights into the design of highly selective catalysts.

有了这个奖项，化学部的化学催化计划正在为田纳西州立大学的教授钥匙限制，以开发一种新型的地球丰富催化剂，以实现有用的耦合反应。目标化学结构，即艾因胺代表了具有化学，药物和生物学领域的应用的非常重要的化合物。目前，这种耦合反应采用了贵金属催化剂，这些珍贵催化剂有时是昂贵的，有时有毒且供应量有限。 因此，当今最常见的方法构成了经济和经常面临的环境挑战。开发与地球丰富金属系统这种反应的催化过程与可持续化学目标兼容。 这里的成功也可能吸引了药物过程组和工业化学家的注意。这项研究的更广泛影响包括针对本科生，硕士研究人员和高中生的培训机会和动手研究经验，包括来自人为人数不足的团体和低收入背景的学生。丁教授正在研究轻度条件下对酒精胺耦合的催化反应性。在当前研究的系统中，配体不仅充当金属结合位点，而且还直接参与化学键激活。该项目正在探索酒精和胺的最佳反应条件和底物范围。通过合并的实验和理论研究研究了重要的反应中间体和催化机制，这将丰富对这种转化的非副金属催化的基本理解，并将为高度选择性催化剂设计提供新的见解。

项目成果

Switching between borrowing hydrogen and acceptorless dehydrogenative coupling by base transition-metal catalysts

• DOI: 10.1016/j.tet.2021.132451
• 发表时间: 2021-09
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Keying Ding

Switchable Imine and Amine Synthesis Catalyzed by a Well-Defined Cobalt Complex

• DOI: 10.1021/acs.organomet.0c00727
• 发表时间: 2021-01
• 期刊: Organometallics
• 影响因子: 2.8
• 作者: K. Paudel;Shi Xu;O. Hietsoi;Bedraj Pandey;Chuka Onuh;Keying Ding

Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols

钴催化的伯醇对腈的α-烯烃化和α-烷基化

• DOI: 10.1021/acs.orglett.1c01553
• 发表时间: 2021
• 期刊: Organic Letters
• 影响因子: 5.2
• 作者: Paudel, Keshav;Xu, Shi;Ding, Keying
• 通讯作者: Ding, Keying