Alkaloid Synthesis Using Aminal Radicals

使用氨基自由基合成生物碱

• 批准号: 1465287
• 负责人: Christopher Beaudry
• 金额: $ 39万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465287&HistoricalAwards=false
• 关键词: Alkaloid; Synthesis; Using; Aminal; Radicals

In this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Christopher M. Beaudry of Oregon State University is developing efficient methods for the construction of molecules with complex architectures that contain nitrogen. Since the vast majority of biologically active molecules are nitrogenous, this research will create new opportunities for the identification of biologically active molecules. Synthetic molecules are being tested for their ability to serve as pharmaceutical lead compounds, biological probes, and selective inhibitors of cellular proteins. Researchers contributing to this work represent a diverse multiracial, multicultural, multi-gender group of scientists. Professor Beaudry supervises formal weekly and monthly research meetings where scientists are trained for experimentation and dissemination of the work. Moreover, the diverse Beaudry group actively participates in community outreach and lifelong learning with the Oregon Museum of Science and Industry, "Science Pub," a locally-organized discussion of science, and organization of the Pacific Northwest Undergraduate Research Symposium.More technically, the project focuses on study and development of new chemical reactions of carbon-centered radicals that bear two nitrogen atoms. Such aminal radicals are used to create new carbon-carbon bonds in molecules containing heteroatoms, such as pharmaceuticals and natural products. The use of these radicals allows efficient syntheses of target molecules while avoiding acid-base chemistry of nitrogen, and as such represents a new strategy for chemical synthesis.

在这个由化学系化学合成项目资助的项目中，克里斯托弗·M。俄勒冈州州立大学的Beaudry正在开发有效的方法来构建具有复杂结构的含氮分子。 由于绝大多数生物活性分子是含氮的，这项研究将为鉴定生物活性分子创造新的机会。合成分子正在测试它们作为药物先导化合物、生物探针和细胞蛋白质选择性抑制剂的能力。为这项工作做出贡献的研究人员代表了一个多元化的多种族，多文化，多性别的科学家群体。Beaudry教授监督每周和每月的正式研究会议，科学家们在那里接受实验和工作传播的培训。 此外，多元化的Beaudry小组积极参与社区外展和终身学习，与俄勒冈州科学与工业博物馆、当地组织的科学讨论“科学酒吧”以及太平洋西北大学本科生研究研讨会的组织合作。从技术上讲，该项目的重点是研究和开发带有两个氮原子的碳中心自由基的新化学反应。这种缩醛胺自由基用于在含有杂原子的分子中产生新的碳-碳键，例如药物和天然产物。这些自由基的使用允许目标分子的有效合成，同时避免氮的酸碱化学，因此代表了化学合成的新策略。