PFI:AIR - TT: High yield production of furans from biomass hydrolysates using a hybrid enzyme- and chemo-catalytic technology

PFI:AIR - TT：使用混合酶和化学催化技术从生物质水解产物中高产生产呋喃

• 批准号: 1500273
• 负责人: Patricia Relue
• 金额: $ 20万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2021-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1500273&HistoricalAwards=false
• 关键词: PFI; AIR; TT; yield; production

This PFI: AIR Technology Translation project focuses on a transformative technology for converting biomass to platform chemicals (furans) that would replace petroleum-derived feedstocks for fuel and chemical production. These furans serve as building blocks for a variety of other chemicals and intermediates that are necessary in industry. A process that allows them to be economically produced from renewable resources (e.g. biomass) instead of petroleum-based technologies would result in reduced dependence on fossil fuels, reduced emission of greenhouse gases, and minimal environmental impact. The project will result in a proof-of-concept development, demonstration, and evaluation of an integrated hybrid enzyme-and chemo-catalytic technology for high-yield production of furans from biomass sugars. When compared to competing processes that rely on inefficient water-based reaction media, the technology has several distinct advantages. It provides a cohesive pathway to efficiently transfer biomass sugars into a non-aqueous reaction medium; produces the furan product in high yield; and isolates the furan for downstream processing, all with low energy input and recycling of process streams. This project addresses the following technology gaps as it translates from research discovery toward commercial application: (1) the design, construction, and testing of a scalable process configuration that allows transition from bench to larger scale; (2) the collection of metrics for the prolonged operation of the integrated process; (3) the assessment of the process economics and environmental impacts; and (4) the evaluation of the integrated process with diverse biomass feedstocks and their upstream pretreatment/saccharification methods. In addition, personnel involved in this project, namely undergraduate and graduate students, will receive entrepreneurship and innovation experiences through new interdisciplinary initiatives developed at The University of Toledo based on the Lean LaunchPad approach.

该PFI: AIR技术翻译项目侧重于将生物质转化为平台化学品（呋喃）的变革性技术，该技术将取代用于燃料和化学品生产的石油衍生原料。这些呋喃是工业中必需的各种其他化学品和中间体的基础。利用可再生资源（如生物质）而不是以石油为基础的技术经济地生产这些产品的过程将减少对化石燃料的依赖，减少温室气体的排放，并将对环境的影响降到最低。该项目将对从生物质糖中高产产呋喃的综合混合酶和化学催化技术进行概念开发、演示和评估。与依赖低效水基反应介质的竞争工艺相比，该技术有几个明显的优势。它提供了一个内聚途径，有效地将生物质糖转移到非水反应介质中；高收率生产呋喃产品；并将呋喃分离出来用于下游加工，所有这些都是低能量投入和工艺流程的循环利用。该项目解决了从研究发现到商业应用的以下技术差距：(1)可扩展工艺配置的设计、构建和测试，允许从实验台过渡到更大规模；(2)集成过程长期运行的指标收集；(3)工艺经济和环境影响评价；(4)不同生物质原料组合工艺及其上游预处理/糖化方法的评价。此外，参与该项目的人员，即本科生和研究生，将通过托莱多大学基于精益LaunchPad方法开发的新的跨学科计划获得创业和创新经验。