Collaborative Research: RUI: Ion Mobility Spectrometry Radiative Ion-Ion Neutralization for gas-phase ion transduction

在化学系化学测量和成像项目的支持下，Azusa太平洋大学（APU）的Davis教授和华盛顿州立大学（WSU）的charles教授正在探索一种新的方法，使用一种称为辐射离子中和（RIIN）的技术来检测和表征痕量水平的化学物质。在博士的指导下。戴维斯和克洛斯是一个由本科生和研究生组成的联合研究团队，他们提出了一种化学检测的创新方法，这种方法有可能直接造福于民用和军事领域中用于环境监测、医疗诊断和威胁检测的许多现有技术。目前在现场检测微量化学物质的方法往往依赖于不仅忽略诊断有用信息的技术，而且限制了可能达到的化学检测极限。辐射离子-离子中和（RIIN）机制的成功表征提高了从初步安全筛选到生物化学的快速化学测量和影响领域提供的信息水平。通过这个项目的实施，来自APU的学生有机会在夏季学术月份前往WSU与博士和他的学生一起在研究生水平的研究环境中工作，而来自WSU的学生有机会在学年期间前往APU获得领导研究和指导本科生研究助理的经验。现有的高压离子检测方法受到模拟电路信噪性能特性的固有限制。目前，没有一种兼容的离子扩增技术能够在大气条件下进行单离子计数。这限制了离子迁移率光谱法作为一种痕量分析工具的发展。辐射离子中和（RIIN）提供了一种记录气相离子信号的新手段，它还将光谱学与传统的离子迁移率测量相结合。RIIN检测平台的开发和表征有三个目标：1)开发RIIN作为定量气相离子转导机制；2) RIIN光子释放机制的确定；3)利用波长分辨的RIIN信号进行化学识别。RIIN系统提供的独特信号转导直接有利于专注于表征大气压气相离子的平台，并增加了高信息量的第二维信息，可以更精确地评估复杂混合物的化学含量。这项工作的一个同样重要的目标是将riin信息气相光谱集成到离子迁移实验中。由此产生的多维平台代表了一种新的分析方法和直接探测气相离子的化学官能团的手段。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Davis at Azusa Pacific University APU) and Professor Clowers at Washington State University (WSU) are pursuing a new approach for detecting and characterizing chemicals at trace levels using a technique termed Radiative Ion-Ion Neutralization (RIIN). Under the guidance of Drs. Davis and Clowers, a combined team of undergraduate and graduate researchers advance an innovative approach to chemical detection that has the potential to directly benefit a number of existing technologies routinely used for environmental monitoring, medical diagnostics, and threat detection in both the civilian and military domains. Current methods for detecting trace chemicals in the field often rely upon technology that not only ignores diagnostically-useful information, but restricts the chemical detection limits that may be reached. Successful characterization of the Radiative Ion-Ion Neutralization (RIIN) mechanism enhances the levels of information provided from rapid chemical measurements and impact fields from preliminary security screening to biochemistry. Through the implementation of this project, students from APU have the opportunity to travel to WSU during the summer academic months to work with Dr. Clowers and his students in a graduate-level research environment while students from WSU have the opportunity to travel to APU during the academic year to gain experience leading research and mentoring undergraduate research assistants. Existing approaches for ion detection at high pressure are inherently limited by the signal-to-noise performance characteristics of analog circuitry. At present, no compatible ion amplification technology is capable of single ion-counting under atmospheric conditions. This has constrained the growth and development of ion mobility spectrometry as a trace analytical tool. Radiative Ion-Ion Neutralization (RIIN) provides a new means of recording gas-phase ion signals that also integrates optical spectroscopy with traditional ion mobility measurements. The development and characterization of the RIIN detection platform is pursued across three objectives: 1) Development of RIIN as a quantitative gas-phase ion-transduction mechanism; 2) Determination of the RIIN photon release mechanism; and 3) Leveraging wavelength resolved RIIN signals for chemical identification. The unique signal transduction provided by the RIIN system directly benefits platforms focused on characterizing atmospheric pressure gas-phase ions and adds a highly informative second dimension of information that can more precisely assess the chemical content of complex mixtures. An equally important goal of this work is the integration of RIIN-informed gas-phase spectroscopy into the ion mobility experiment. The resulting multidimensional platform represents both a new analytical methodology and means of directly probing the chemical functional groups for gas-phase ions.