Collaborative Research: RUI: Ion Mobility Spectrometry Radiative Ion-Ion Neutralization for gas-phase ion transduction

合作研究：RUI：用于气相离子转导的离子淌度谱辐射离子-离子中和

• 批准号: 1507155
• 负责人: Eric Davis
• 金额: $ 15.9万
• 依托单位: Azusa Pacific University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507155&HistoricalAwards=false
• 关键词: Collaborative; Research; RUI; Ion; Mobility

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Davis at Azusa Pacific University APU) and Professor Clowers at Washington State University (WSU) are pursuing a new approach for detecting and characterizing chemicals at trace levels using a technique termed Radiative Ion-Ion Neutralization (RIIN). Under the guidance of Drs. Davis and Clowers, a combined team of undergraduate and graduate researchers advance an innovative approach to chemical detection that has the potential to directly benefit a number of existing technologies routinely used for environmental monitoring, medical diagnostics, and threat detection in both the civilian and military domains. Current methods for detecting trace chemicals in the field often rely upon technology that not only ignores diagnostically-useful information, but restricts the chemical detection limits that may be reached. Successful characterization of the Radiative Ion-Ion Neutralization (RIIN) mechanism enhances the levels of information provided from rapid chemical measurements and impact fields from preliminary security screening to biochemistry. Through the implementation of this project, students from APU have the opportunity to travel to WSU during the summer academic months to work with Dr. Clowers and his students in a graduate-level research environment while students from WSU have the opportunity to travel to APU during the academic year to gain experience leading research and mentoring undergraduate research assistants. Existing approaches for ion detection at high pressure are inherently limited by the signal-to-noise performance characteristics of analog circuitry. At present, no compatible ion amplification technology is capable of single ion-counting under atmospheric conditions. This has constrained the growth and development of ion mobility spectrometry as a trace analytical tool. Radiative Ion-Ion Neutralization (RIIN) provides a new means of recording gas-phase ion signals that also integrates optical spectroscopy with traditional ion mobility measurements. The development and characterization of the RIIN detection platform is pursued across three objectives: 1) Development of RIIN as a quantitative gas-phase ion-transduction mechanism; 2) Determination of the RIIN photon release mechanism; and 3) Leveraging wavelength resolved RIIN signals for chemical identification. The unique signal transduction provided by the RIIN system directly benefits platforms focused on characterizing atmospheric pressure gas-phase ions and adds a highly informative second dimension of information that can more precisely assess the chemical content of complex mixtures. An equally important goal of this work is the integration of RIIN-informed gas-phase spectroscopy into the ion mobility experiment. The resulting multidimensional platform represents both a new analytical methodology and means of directly probing the chemical functional groups for gas-phase ions.

在化学划分的化学测量和成像计划的支持下，Azusa Pacific University APU的戴维斯教授和华盛顿州立大学（WSU）的Clowers教授正在采用一种新的方法，该方法使用称为辐射离子离子中和化学技术来检测和表征痕量水平的化学物质（RIIN）。在博士的指导下。戴维斯（Davis and Clowers）是一支由本科和研究生研究人员组成的组合团队，提高了一种创新的化学检测方法，有可能直接使许多用于环境监测，医疗诊断和平民领域的威胁检测的现有技术受益。当前检测田间痕量化学物质的方法通常依赖于忽略诊断性信息的技术，而且限制了可能达到的化学检测限制。辐射离子离子中和（RIIN）机制的成功表征增强了从快速化学测量和从初步安全筛查到生物化学的影响领域提供的信息水平。通过实施该项目，来自APU的学生有机会在夏季学年中前往WSU，与Clowers博士和他的学生一起在研究生级的研究环境中与他合作，而WSU的学生有机会在学年期间前往APU，以获得领先的研究经验，并指导了研究生和指导本科生研究助理。 在高压下进行离子检测的现有方法固有地受到模拟电路的信噪性能特征的限制。 目前，在大气条件下，没有兼容的离子扩增技术能够单个离子计数。这限制了离子迁移率光谱法作为痕量分析工具的生长和发展。 辐射离子离子中和（RIIN）提供了一种记录气相离子信号的新方法，该信号还将光谱与传统离子迁移率测量相结合。 RIIN检测平台的开发和表征是在三个目标中追求的：1）RIIN作为定量气相离子转导机制的发展； 2）确定RIIN光子释放机制； 3）利用波长解析的RIIN信号进行化学识别。 RIIN系统提供的独特信号转导直接使平台旨在表征大气压力气相离子，并增加了信息的高度信息，可以更精确地评​​估复杂混合物的化学含量。这项工作同样重要的目标是将RIIN信息的气相光谱整合到离子迁移率实验中。所得的多维平台既代表了一种新的分析方法，也代表了直接探测气相离子化学官能团的手段。