A role for Cited2, Transforming Growth Factor-beta and matrix metaloproteinases in trophoblast invasion and placenta formation

Cited2、转化生长因子-β 和基质金属蛋白酶在滋养层侵袭和胎盘形成中的作用

• 批准号: DP0878081
• 负责人: Prof Sally Dunwoodie
• 金额: $ 17.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878081
• 关键词: role; Cited2; Transforming; Growth; Factor

The placenta is essential for the growth and development of the fetus, and if it fails to form correctly during pregnancy, it can have dramatic effects that can result death in utero, or adult onset diseases. Our research aims to understand how one protein functions in placenta formation. We will also investigate how this protein works at the molecular level in a process that enables single cells to respond to molecules sent from a distance by other cells (TGF-beta signalling). This process is also very important for a host of other biological processes relevant to human health, including cancer.

胎盘对胎儿的生长和发育至关重要，如果它在怀孕期间未能正确形成，它可能会产生巨大的影响，可能导致子宫内死亡或成人发病疾病。我们的研究旨在了解一种蛋白质如何在胎盘形成中发挥作用。我们还将研究这种蛋白质如何在分子水平上发挥作用，使单个细胞能够对其他细胞从远处发送的分子（TGF-β信号传导）做出反应。这一过程对许多与人类健康有关的其他生物过程也非常重要，包括癌症。