Defining in molecular terms cis-inhibition as a means to inhibit Notch signaling

用分子术语将顺式抑制定义为抑制 Notch 信号传导的方法

• 批准号: DP1094119
• 负责人: Prof Sally Dunwoodie
• 金额: $ 27.17万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094119
• 关键词: Defining; molecular; terms; cis; inhibition

Normal development of a baby and our health after birth is dependent on how our cells behave. Signals move between cells and within them to tell them what to do. Proteins interacting with other proteins mostly transmit these signals. This research focuses on a protein named Notch and the signals that it transmits. Notch functions in normal processes, such as blood vessel formation; but abnormal signaling causes and/or contributes to pathological situations such as degenerative disease and cancer. We are working to understand how the Notch signal is made and how to control it when it is abnormal. This will allow new medications to be developed to help people who have cancer and other Notch-related illnesses

婴儿的正常发育和我们出生后的健康取决于我们细胞的行为。信号在细胞之间和细胞内部传递，告诉它们该做什么。与其他蛋白质相互作用的蛋白质大多传递这些信号。这项研究的重点是一种名为Notch的蛋白质及其传递的信号。Notch在正常的过程中发挥作用，如血管形成；但信号异常会导致和/或导致退行性疾病和癌症等病理情况。我们正在努力了解Notch信号是如何产生的，以及当它异常时如何控制它。这将使新药得以开发，以帮助患有癌症和其他诺奇相关疾病的人