RAPID: Collaborative Research: Survival of Ebolavirus in the Water Environment: Surrogate Development and Disinfection Effectiveness

CBET 1508415BibbyCBET 1507285HaasRAPID：合作研究：埃博拉病毒在水环境中的生存：替代发展和消毒能力对埃博拉病毒的命运及其在环境中的生存知之甚少。 在灵长类动物中观察到非直接接触感染，进一步提高了环境感染途径的可能性。作为这一RAPID的初始阶段，将根据已发表的埃博拉病毒在液体培养基中存活的数据，开发埃博拉病毒替代物。 其次，将在环境沃茨（包括水和废水）以及水和废水消毒剂存在的情况下评估这些替代物的存活情况。这项工作将是有价值的，更广泛的环境，公共卫生和风险评估社区提供了现实的替代品，研究（如气溶胶和污染物的生存研究）可能进行。拟议的快速机制是适当的，可以及时通知适当的废物处理。这项工作还将有助于动员和通报对适当废物处理的反应。鉴于BSL 4的获取有限，这种方法是近期内告知埃博拉病毒在水环境中生存以及随后风险评估的最合理的应对措施。该项目的实验工作将在匹兹堡大学进行。数据和统计分析将在德雷克塞尔大学进行。拟议的研究将通过告知适当处理埃博拉病毒污染的废物来造福社会。拟议的工作将通过期刊出版物和会议记录广泛传播。这项拟议中的研究将填补埃博拉病毒污染废物的生存和适当处理方面的现有知识空白。这项研究还将开发和验证可供更广泛的环境工程和公共卫生研究界用于埃博拉病毒生存研究的替代品。

CBET 1508415BibbyCBET 1507285HaasRAPID: Collaborative Research: Survival of Ebola virus in the Water Environment: Surrogate Development and Disinfection EffectivenessLittle is known about the fate of Ebola virus and its survival in the environment. Infection in primates has been observed from non-direct contact, raising further the possibility of an environmental infection route. As an initial phase of this RAPID, Ebola virus surrogates, based upon the published data of Ebola virus survival in liquid media, will be developed. Second, the survival of these surrogates will be evaluated in environmental waters (including water and wastewater) and in the presence of water and wastewater disinfectants. This work will be valuable to the broader environmental, public health, and risk assessment communities by providing access to realistic surrogates with which studies (e.g. aerosol and fomite survival studies) may be conducted. The proposed RAPID mechanism is appropriate to inform proper waste handling in a timely manner. This work will also serve to mobilize and inform a response to proper waste handling. Given limited BSL4 access, this approach is the most reasonable response in the near term to inform Ebola virus survival in the water environment, and subsequent risk assessment. Experimental work on this project will be conducted at the University of Pittsburgh. Data and statistical analysis will be conducted at Drexel University. The proposed research will benefit society through informing proper handling of Ebola virus contaminated waste. The proposed work will be disseminated broadly through journal publications and conference proceedings. The proposed research will fill in an existing knowledge gap in the survival and proper handling of Ebola virus contaminated waste. This research will also develop and verify surrogates that may be used by the broader environmental engineering and public health research communities for Ebola virus survival studies.