RCN: Wastewater Surveillance for SARS-CoV-2 and Emerging Public Health Threats

RCN:针对 SARS-CoV-2 和新出现的公共卫生威胁的废水监测

基本信息

  • 批准号:
    2202361
  • 负责人:
  • 金额:
    $ 50万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

The ongoing COVID-19 pandemic remains an urgent national and global threat to public health. Wastewater surveillance (WWS) has emerged as a versatile and complementary platform to existing clinical tools for monitoring and tracking the spread and transmission of COVID-19 in communities. The basic premise of WSS is that the detection and quantification of microbial and viral biomarkers extracted from samples of untreated wastewater can be used to monitor the onset, spread and community transmission of infectious pathogens such as the SARS-CoV-2 virus and its variants. The overarching goal of this Research Coordination Network (RCN) is to support the large community of practitioners and stakeholders that employ WWS as a public health monitoring tool. To advance this goal, the core investigators of this RCN and their national/international partners will integrate their expertise and leverage their resources to address critical knowledge gaps and needs in WSS including improved analytical and sampling methods and more effective collaboration, communication and information sharing protocols/tools among researchers, practitioners, and public health stakeholders. The successful completion of this project will benefit society through the development and dissemination of new tools and protocols to support the large community of practitioners that employ WWS to monitor SARS-CoV-2 and other pathogens, including those capable of causing future pandemics. Additional benefits to society will be achieved through workforce development including the mentoring of two post-doctoral research fellows at the University of Notre Dame and Howard University. Early success in the use of wastewater surveillance (WSS) during the COVID-19 pandemic in the United States has led to the establishment of a National Wastewater Surveillance System. Although the use of WWS has provided critical data and valuable insight into the spread and transmission of SARS-CoV-2, much work remains to be done to enable quantitative estimates, predictions, and actionable public health recommendations from the analysis of the data collected during a community wastewater surveillance program. This NSF Research Coordination Network (RCN) will address these critical knowledge gaps. The RCN builds upon the accomplishments of a previous NSF EAGER award that established a network of WWS researchers and practitioners from academia, government agencies, non-governmental organizations, and industry. The new RCN will advance its research, education, and workforce development goals through the implementation of five synergistic activities including 1) Monthly seminar series, 2) Quarterly topical workshops, 3) Development of a community-led ‘Wiki’ on the state of the science of WWS, 4) Annual wastewater surveillance training bootcamp, and 5) Annual virtual RCN conference with researchers, practitioners, and public health decision-makers. Through this award, the RCN investigators and their partners will facilitate and promote collaboration and communication among researchers, practitioners, and public health policy and decision-makers to advance next generation WWS for pandemic preparedness and prevention.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
持续的COVID-19大流行仍然是对国家和全球公共卫生的紧迫威胁。废水监测(WWS)已成为现有临床工具的通用和补充平台,用于监测和跟踪COVID-19在社区中的传播和传播。WSS的基本前提是,从未经处理的废水样品中提取的微生物和病毒生物标志物的检测和定量可用于监测传染性病原体(如SARS-CoV-2病毒及其变体)的发病、传播和社区传播。该研究协调网络(RCN)的总体目标是支持将WWS用作公共卫生监测工具的大型从业者和利益相关者社区。为了推进这一目标,该RCN的核心研究人员及其国家/国际合作伙伴将整合他们的专业知识,并利用他们的资源来解决WSS中的关键知识差距和需求,包括改进分析和采样方法以及研究人员,从业人员和公共卫生利益相关者之间更有效的合作,沟通和信息共享协议/工具。该项目的成功完成将通过开发和传播新工具和协议来支持使用WWS监测SARS-CoV-2和其他病原体(包括那些能够导致未来大流行的病原体)的广大从业者社区,从而使社会受益。通过劳动力发展,包括指导圣母大学和霍华德大学的两名博士后研究员,将为社会带来更多的好处。美国在2019冠状病毒病大流行期间使用废水监测(WSS)的早期成功导致建立了国家废水监测系统。尽管WWS的使用为SARS-CoV-2的传播和传播提供了关键数据和有价值的见解,但仍有许多工作要做,以便通过分析社区废水监测计划期间收集的数据进行定量估计,预测和可操作的公共卫生建议。这个NSF研究协调网络(RCN)将解决这些关键的知识差距。RCN建立在以前的NSF EAGER奖的成就之上,该奖项建立了来自学术界,政府机构,非政府组织和工业界的WWS研究人员和从业人员的网络。新的RCN将通过实施五项协同活动来推进其研究,教育和劳动力发展目标,包括1)每月研讨会系列,2)季度专题研讨会,3)开发社区主导的WWS科学状态“Wiki”,4)年度废水监测培训训练营,以及5)与研究人员,从业人员,和公共卫生决策者。通过该奖项,RCN研究人员及其合作伙伴将促进和促进研究人员、从业人员、公共卫生政策制定者和决策者之间的合作和沟通,以推动下一代WWS用于大流行的准备和预防。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

项目成果

期刊论文数量(0)
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Kyle Bibby其他文献

A highly prevalent and specific cryptic plasmid pBI143 for human fecal pollution tracking in a subtropical urban river
一种用于亚热带城市河流中人类粪便污染追踪的高流行且特异性的隐蔽质粒pBI143
  • DOI:
    10.1016/j.watres.2024.122992
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    12.400
  • 作者:
    Yawen Liu;Wendy J.M. Smith;Metasebia Gebrewold;Rory Verhagen;Stephen Cook;Stuart L. Simpson;Bethany Oceguera Johnson;Kyle Bibby;Warish Ahmed
  • 通讯作者:
    Warish Ahmed
Metagenomics and the development of viral water quality tools
宏基因组学与病毒水质工具的开发
  • DOI:
    10.1038/s41545-019-0032-3
  • 发表时间:
    2019-03-04
  • 期刊:
  • 影响因子:
    11.400
  • 作者:
    Kyle Bibby;Katherine Crank;Justin Greaves;Xiang Li;Zhenyu Wu;Ibrahim A. Hamza;Elyse Stachler
  • 通讯作者:
    Elyse Stachler
Temporal, spatial, and methodological considerations in evaluating the viability of measles wastewater surveillance
评估麻疹废水监测可行性的时间、空间和方法学考虑因素
  • DOI:
    10.1016/j.scitotenv.2024.178141
  • 发表时间:
    2025-01-10
  • 期刊:
  • 影响因子:
    8.000
  • 作者:
    William Chen;Kyle Bibby
  • 通讯作者:
    Kyle Bibby
Evaluating Nanotrap Microbiome Particles as A Wastewater Viral Concentration Method
  • DOI:
    10.1007/s12560-024-09628-w
  • 发表时间:
    2025-01-04
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Marlee Shaffer;Devin North;Kyle Bibby
  • 通讯作者:
    Kyle Bibby
Environmental DNA (eDNA) removal rates in streams differ by particle size under varying substrate and light conditions
在不同的基质和光照条件下,溪流中环境 DNA(eDNA)的去除率因颗粒大小而异。
  • DOI:
    10.1016/j.scitotenv.2023.166469
  • 发表时间:
    2023-12-10
  • 期刊:
  • 影响因子:
    8.000
  • 作者:
    Elise D. Snyder;Jennifer L. Tank;Pedro F.P. Brandão-Dias;Kyle Bibby;Arial J. Shogren;Aaron W. Bivins;Brett Peters;Erik M. Curtis;Diogo Bolster;Scott P. Egan;Gary A. Lamberti
  • 通讯作者:
    Gary A. Lamberti

Kyle Bibby的其他文献

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{{ truncateString('Kyle Bibby', 18)}}的其他基金

2022 Microbiology of the Built Environment GRC & GRS
2022年建筑环境GRC微生物学
  • 批准号:
    2225710
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Collaborative Research: RAPID: Wastewater Informed Epidemiological Monitoring of SARS-CoV-2
合作研究:RAPID:废水知情的 SARS-CoV-2 流行病学监测
  • 批准号:
    2027752
  • 财政年份:
    2020
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
EAGER: Infectious Norovirus Persistence in Water
EAGER:传染性诺如病毒在水中的持久性
  • 批准号:
    2006326
  • 财政年份:
    2020
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
EAGER: RCN: Wastewater Surveillance of SARS-CoV-2
EAGER:RCN:SARS-CoV-2 废水监测
  • 批准号:
    2038087
  • 财政年份:
    2020
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
CAREER: Quantitative Viral Metagenomics for Water Quality Assessment
职业:用于水质评估的定量病毒宏基因组学
  • 批准号:
    1748019
  • 财政年份:
    2017
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
CAREER: Quantitative Viral Metagenomics for Water Quality Assessment
职业:用于水质评估的定量病毒宏基因组学
  • 批准号:
    1653356
  • 财政年份:
    2017
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
UNS: Developing Cross-Assembly Phage As A Marker of Human Fecal Pollution in the Environment
UNS:开发交叉组装噬菌体作为环境中人类粪便污染的标志
  • 批准号:
    1818412
  • 财政年份:
    2017
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Workshop Proposal: Wastewater Handling in Outbreak Response - Lessons and Research Needs from the 2014/15 Ebola Virus Outbreak
研讨会提案:疫情应对中的废水处理 - 2014/15 埃博拉病毒爆发的经验教训和研究需求
  • 批准号:
    1612429
  • 财政年份:
    2016
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
UNS: Developing Cross-Assembly Phage As A Marker of Human Fecal Pollution in the Environment
UNS:开发交叉组装噬菌体作为环境中人类粪便污染的标志
  • 批准号:
    1510925
  • 财政年份:
    2015
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
RAPID: Collaborative Research: Survival of Ebolavirus in the Water Environment: Surrogate Development and Disinfection Effectiveness
RAPID:合作研究:埃博拉病毒在水环境中的生存:替代品开发和消毒效果
  • 批准号:
    1508415
  • 财政年份:
    2014
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant

相似海外基金

LEAPS-MPS: Enhancing Dynamic Population-Level Epidemiological Models by Incorporating Wastewater Surveillance Data
LEAPS-MPS:通过纳入废水监测数据来增强动态人口水平流行病学模型
  • 批准号:
    2316809
  • 财政年份:
    2023
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Using wastewater surveillance data to study SARS-CoV-2 dynamics and predict COVID-19 outcomes
利用废水监测数据研究 SARS-CoV-2 动态并预测 COVID-19 结果
  • 批准号:
    10645617
  • 财政年份:
    2023
  • 资助金额:
    $ 50万
  • 项目类别:
Point-of-Collection Sample Pretreatment and Preservation with Porous Super-Absorbent Polymer (PSAP) Beads for Wastewater Surveillance Testing
使用多孔高吸水性聚合物 (PSAP) 珠进行收集点样品预处理和保存,用于废水监测测试
  • 批准号:
    2228300
  • 财政年份:
    2023
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Feasibility of conducting HIV surveillance in community wastewater
在社区废水中进行艾滋病毒监测的可行性
  • 批准号:
    10762254
  • 财政年份:
    2023
  • 资助金额:
    $ 50万
  • 项目类别:
Wastewater-Based Surveillance Integration with Health Decision-Making: Protection Against Health Threats and Promotion of Health Equity
基于废水的监测与健康决策的整合:防范健康威胁并促进健康公平
  • 批准号:
    499020
  • 财政年份:
    2023
  • 资助金额:
    $ 50万
  • 项目类别:
    Salary Programs
Modelling the effect of public health interventions on COVID-19 case counts in a closed population through wastewater surveillance: implications in infectious disease outbreak response and epidemiology
通过废水监测模拟公共卫生干预措施对封闭人群中 COVID-19 病例数的影响:对传染病爆发应对和流行病学的影响
  • 批准号:
    486062
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:
    Studentship Programs
Strengthening COVID-19 prevention strategies via wastewater surveillance in a Northern Plains Tribe
通过北部平原部落的废水监测加强 COVID-19 预防策略
  • 批准号:
    10436763
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:
Operationalizing wastewater-based surveillance of multidrug-resistant bacteria
实施基于废水的多重耐药细菌监测
  • 批准号:
    10449747
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:
SARS-CoV-2 in Correctional Populations: A collaborative, ethical approach to application of wastewater-based surveillance
惩教人群中的 SARS-CoV-2:应用基于废水的监测的协作、道德方法
  • 批准号:
    10546510
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:
Improving influenza vaccines through wastewater-based macro-scale strain surveillance
通过基于废水的宏观毒株监测改进流感疫苗
  • 批准号:
    10385514
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
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