UNS:Collaborative Research: Coded-illumination Fourier Ptychography for High-content Multimodal Imaging

摘要（协作）PI：郑国安提案：1510077 PI：DiMarzio，Charles Proposal：1510280该项目将开发一种具有超高灵敏度和超高分辨率的新型原型显微镜，同时能够在大视场和快速成像下提供3D成像。该提案旨在开发一种新型的显微镜技术（编码照明傅立叶重叠关联成像），该技术结合了新颖的傅立叶数据恢复，组织切片结构化照明，多层建模和光谱复用的创新。数据采集的迭代用于优化最终图像解决方案。增加的图像维度，无论是光谱的还是空间的，都是高度期望的商品。如果这些技术可以成为常规，那么显微镜的许多领域都可以受益。该提案反映了对妇女的大量外联活动以及对研究生和本科生的重大教育努力。

Abstract (Collaborative) PI: Zheng, Guoan Proposal:1510077 PI: DiMarzio, Charles Proposal: 1510280 This project will develop a new prototype microscope of ultra-high sensitivity with super-high resolution, yet with the ability to provide 3D imaging at a large field-of-view and rapid imaging. The proposal aims to develop a new type of microscopy technique, (coded-illumination Fourier ptychography), that incorporates the innovations of novel Fourier data recovery, structured illumination for tissue sectioning, multi-layer modeling, and spectrum multiplexing. Iteration across data acquisitions is used to optimize to a final image solution. Increased image dimensionality, either spectral or spatial, is a highly desired commodity. If these techniques can be made routine, then many areas of microscopy could benefit. The proposal reflects substantial outreach to women and significant educational efforts towards graduates and undergraduates.