UNS:Collaborative Research: Coded-illumination Fourier Ptychography for High-content Multimodal Imaging

UNS：合作研究：用于高内涵多模态成像的编码照明傅立叶叠印术

• 批准号: 1510281
• 负责人: Charles DiMarzio
• 金额: $ 29.99万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1510281&HistoricalAwards=false
• 关键词: UNS; Collaborative; Research; Coded; illumination

Abstract (Collaborative) PI: Zheng, Guoan Proposal:1510077 PI: DiMarzio, Charles Proposal: 1510280 This project will develop a new prototype microscope of ultra-high sensitivity with super-high resolution, yet with the ability to provide 3D imaging at a large field-of-view and rapid imaging. The proposal aims to develop a new type of microscopy technique, (coded-illumination Fourier ptychography), that incorporates the innovations of novel Fourier data recovery, structured illumination for tissue sectioning, multi-layer modeling, and spectrum multiplexing. Iteration across data acquisitions is used to optimize to a final image solution. Increased image dimensionality, either spectral or spatial, is a highly desired commodity. If these techniques can be made routine, then many areas of microscopy could benefit. The proposal reflects substantial outreach to women and significant educational efforts towards graduates and undergraduates.

摘要（合作） 负责人：郑国安 提案：1510077 负责人：DiMarzio, Charles 提案：1510280 该项目将开发一种新型超高灵敏度、超高分辨率原型显微镜，同时能够提供大视场 3D 成像和快速成像。该提案旨在开发一种新型显微镜技术（编码照明傅立叶叠层成像），该技术融合了新型傅立叶数据恢复、组织切片结构化照明、多层建模和光谱复用的创新。跨数据采集的迭代用于优化最终图像解决方案。增加图像维度（无论是光谱还是空间）是人们非常渴望的商品。如果这些技术能够成为常规技术，那么显微镜的许多领域都可以受益。该提案反映了对妇女的大量宣传以及对研究生和本科生的重大教育努力。