EAPSI: Transport of Chromium(III) Under Elevated Glycemic Conditions in Vivo

EAPSI:体内血糖升高条件下铬 (III) 的转运

基本信息

  • 批准号:
    1515043
  • 负责人:
  • 金额:
    $ 0.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-06-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

Significant interest exists in treating diabetes, including the potential of chromium (Cr) to reduce its symptoms. As diabetics have a surplus of glucose in their bodies, blood serum proteins can be glycosylated to a greater extent than normal, resulting in detrimental effects on the hosts. Previously glycosylation of the iron transport protein transferrin (Tf) has shown to alter its function. As transferrin also transports chromium from the bloodstream to tissues, glycosylation of transferrin may also significantly affect chromium transport to the tissues; however, these effects have not been examined to date. This award supports research to explore the effect of glycosylation of transferrin on the uptake of chromium(III) using a rodent model system. The research will be conducted at National Chung Hsing University under the mentorship of Dr. Frank Moa and Dr. Wen-Ying Chen, experts in the effects of chromium in model rodent systems.This project will explore the effect of glycosylation of transferrin on the uptake of chromium(III) in healthy, type 1, and type 2 diabetic animal models. Diabetes is a worldwide problem, and a potential therapeutic agent to treat symptoms of this disease that has received appreciable attention is chromium(III). Chromium(III) has been shown to increase insulin sensitivity and improve cholesterol and triglyceride levels in rodent models of diabetes. One side effect of diabetes is increased blood glucose levels. As a result of the higher glucose levels, blood serum proteins can become irreversibly glycosylated. Glycosylation can alter the properties and functions of these proteins, including the iron transport protein transferrin. Transferrin not only carries iron in the bloodstream but also appears to be the sole agent that transports chromium(III) from the bloodstream to the tissues. Thus, glycosylation of transferrin of diabetic subjects could alter the ability for chromium(III) to be transferred to tissues and thus increase insulin sensitivity in tissues. This NSF EAPSI award supports the research of a U.S. graduate student and is funded in collaboration with the Ministry of Science and Technology of Taiwan.
人们对治疗糖尿病非常感兴趣,其中包括铬 (Cr) 减轻糖尿病症状的潜力。由于糖尿病患者体内葡萄糖过剩,血清蛋白的糖基化程度会高于正常水平,从而对宿主产生不利影响。 此前,铁转运蛋白转铁蛋白 (Tf) 的糖基化已显示会改变其功能。 由于转铁蛋白还将铬从血流转运至组织,因此转铁蛋白的糖基化也可能显着影响铬向组织的转运;然而,迄今为止这些影响尚未得到检验。该奖项支持使用啮齿动物模型系统探索转铁蛋白糖基化对铬 (III) 吸收的影响的研究。该研究将在国立中兴大学在模型啮齿动物系统中铬影响方面的专家 Frank Moa 博士和 Wen-Ying Chen 博士的指导下进行。该项目将探讨转铁蛋白的糖基化对健康、1 型和 2 型糖尿病动物模型中铬 (III) 摄取的影响。糖尿病是一个世界性问题,治疗这种疾病症状的潜在治疗剂是铬(III),它已受到广泛关注。铬(III)已被证明可以提高糖尿病啮齿动物模型的胰岛素敏感性并改善胆固醇和甘油三酯水平。 糖尿病的副作用之一是血糖水平升高。由于葡萄糖水平较高,血清蛋白可能会发生不可逆的糖基化。糖基化可以改变这些蛋白质的特性和功能,包括铁转运蛋白转铁蛋白。转铁蛋白不仅在血液中携带铁,而且似乎是将铬(III)从血液运输到组织的唯一物质。因此,糖尿病受试者的转铁蛋白的糖基化可以改变铬(III)转移到组织的能力,从而增加组织中的胰岛素敏感性。该 NSF EAPSI 奖项支持美国研究生的研究,并由与台湾科学技术部合作资助。

项目成果

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