EAPSI:Mechanical Behavior and Microscopic Changes of Arterial Tissues under External Loading

EAPSI：外部负荷下动脉组织的机械行为和微观变化

• 批准号: 1515100
• 负责人: TRI NGUYEN
• 金额: $ 0.51万
• 依托单位: NGUYEN TRI D
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1515100&HistoricalAwards=false
• 关键词: EAPSI; Mechanical; Behavior; Microscopic; Changes

Heart disease is the leading cause of death for both men and women. Development of new treatment methods has focused on the use of mechanical tools, including mechanical material removal processes to remove plaque. To best develop these processes to fight cardiovascular diseases, researchers must understand the structural changes of the arterial system under similar loading conditions. This award supports research that aims to describe changes in the macro and micro structures of blood vessel tissues experiencing extensile load. The proposed research is innovative in that it uses animal arteries and incorporates the expertise and recently advanced technology of multi-photon microscopy from Dr. Leo Hwa Liang?s Biofluid Mechanics Research Laboratory at the National University of Singapore. In addition to scientific benefits, the project will help a graduate student broaden his interaction with researchers in biomechanical engineering leading center of excellence in Asia. This NSF EAPSI award is funded in collaboration with the National Research Foundation of Singapore. Due to the histological inhomogeneity of arterial walls, a study at the microscopic level is important for understanding the nature of the artery and its response to external loading conditions. In this study, aortic arteries will be cut into tensile test samples in longitudinal, circumferential, and angular directions. The samples will be horizontally stretched using a specially-designed tensile tester under a multi-photon microscope. Various changes in the displacement and interactions of each arterial layer will be analyzed in the areas of deformation, stress, and morphology of elastin and collagen fibers. The significance of the results will explain the role of elastin and collagen fibers in responding to in-body and out-body loading conditions. The proposed research will provide better understanding of mechanical loads on the microscopic architecture of the artery for medical device research and development including machining processes for removing arterial plaque.

心脏病是导致男性和女性死亡的主要原因。新治疗方法的发展主要集中在使用机械工具，包括机械材料去除工艺来去除斑块。为了最好地开发这些过程来对抗心血管疾病，研究人员必须了解在类似负荷条件下动脉系统的结构变化。该奖项支持旨在描述经历拉伸负荷的血管组织的宏观和微观结构变化的研究。拟议的研究是创新的，因为它使用动物动脉，并结合了Leo Hwa Liang博士的专业知识和最近先进的多光子显微镜技术。他是新加坡国立大学生物流体力学研究实验室的研究员。除了科学上的好处外，该项目还将帮助研究生扩大与亚洲领先的生物力学工程卓越中心的研究人员的互动。该奖项由美国国家科学基金会与新加坡国家研究基金会共同资助。由于动脉壁的组织学不均匀性，在微观水平上的研究对于了解动脉的性质及其对外部负载条件的反应是重要的。在这项研究中，主动脉将被切割成纵向、周向和角向的拉伸测试样本。在多光子显微镜下，使用专门设计的拉伸测试仪对样品进行水平拉伸。在每个动脉层的位移和相互作用的各种变化将在变形，应力，弹性蛋白和胶原纤维的形态领域进行分析。该结果的意义将解释弹性蛋白和胶原纤维在响应体内和体外负荷条件中的作用。拟议的研究将为医疗器械的研究和开发提供更好的机械载荷对动脉微观结构的理解，包括去除动脉斑块的加工工艺。