CRCNS: Collaborative Research: Probabilistic Representation of Dynamic Action and Superposition in Spinal Cord Neural Populations - Advancing Theory and Experiment

CRCNS：协作研究：脊髓神经群体动态作用和叠加的概率表示 - 推进理论和实验

• 批准号: 1515140
• 负责人: Simon Giszter
• 金额: $ 30.44万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1515140&HistoricalAwards=false
• 关键词: CRCNS; Collaborative; Research; Probabilistic; Representation

The operation of the brain is not 'clockwork', but rather probabilistic. The project will provide proof of concept data for a new theoretical and experimental framework that utilizes this feature, by using stochastic dynamic operators (SDOs). These new methods have potential to significantly improve predictions of dynamics from recordings of brain function, which in turn would have significant technological and medical impacts in areas including disease process diagnosis, disease control using stimulation, robot prostheses and brain machine interface designs, neural prostheses, and neurally-driven augmentation or replacement. The project brings together a collaboration between an applied mathematician/neurologist and a comparative neurophysiologist, and will provide interdisciplinary graduate and postdoctoral training at the cutting edge of neuroscience, stochastic methods and control. Increasing sophistication of brain recording technology is not fully matched by an equally sophisticated mathematical approach that permits modeling and direct prediction of the relation between behavior and the activity of neural populations. For motor systems, the primary goal is control of dynamics in the environment. The methods under investigation avoid the usual neural separation into sensory and motor effects. They treat neural activity as representing probabilistic alterations of unfolding dynamics. More specifically, the SDO framework considers neural activity as causing a modification of the overall system dynamics, so that the resulting dynamics (including movement, compliance, and oscillatory behavior) achieve a desired result. This allows principled engineering solutions and use of 'big' neural activity to predict dynamics. The proof of concept proposal will test model prediction responses during trajectory formation and perturbation in reflex behavior, prediction of real-time effect of single spikes, and combined effect of multiple neurons/populations. On proof of concept project completion: (1) The SDO framework will be compared with classical techniques using novel data sets; (2) Basic feasibility of real-time robot control from spinal neural activity in a model system will be assessed. Together, these data will all add significantly to neural analysis, neurotechnology and understanding of the novel methods in relation to others.

大脑的运作不是“时钟式的”，而是概率式的。该项目将通过使用随机动态算子（sdo），为利用这一特征的新理论和实验框架提供概念数据验证。这些新方法有可能显著改善脑功能记录对动态的预测，这反过来将在疾病过程诊断、使用刺激的疾病控制、机器人假肢和脑机接口设计、神经假肢和神经驱动的增强或替代等领域产生重大的技术和医学影响。该项目汇集了应用数学家/神经学家和比较神经生理学家之间的合作，并将在神经科学，随机方法和控制的前沿提供跨学科的研究生和博士后培训。越来越复杂的大脑记录技术并没有完全匹配同样复杂的数学方法，允许建模和直接预测行为和神经群活动之间的关系。对于运动系统，主要目标是控制环境中的动力学。所研究的方法避免了通常的神经分离为感觉和运动效应。他们把神经活动看作是展开动力学的概率变化。更具体地说，SDO框架将神经活动视为引起对整个系统动态的修改，以便产生的动态（包括移动、遵从性和振荡行为）达到期望的结果。这允许原则性的工程解决方案和使用“大”神经活动来预测动态。概念验证提案将测试模型在轨迹形成和反射行为扰动期间的预测响应，预测单个峰值的实时效应，以及多个神经元/群体的联合效应。关于概念验证项目的完成：(1)SDO框架将与使用新数据集的经典技术进行比较；(2)在模型系统中通过脊髓神经活动实时控制机器人的基本可行性将被评估。总之，这些数据将大大增加神经分析，神经技术和理解与其他新方法的关系。