SBIR Phase I: Laser-enhanced Hypersensitive Bench-top NMR System

SBIR 第一阶段：激光增强超灵敏台式 NMR 系统

• 批准号: 1520264
• 负责人: Daniela Pagliero
• 金额: $ 15万
• 依托单位: SpinUp NanoSystems LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1520264&HistoricalAwards=false
• 关键词: SBIR; Phase; Laser; enhanced; Hypersensitive

This Small Business Innovation Research Phase I project proposes to develop an optofluidic platform for applications in nuclear magnetic resonance (NMR) that require enhanced detection sensitivity. In the US, NMR accounts for the largest share of the molecular spectroscopy market, with an estimated value of $700 million in 2013 and $1 billion in 2018. The compact, portable system that will result from this work will find applications in existing, emerging, or new markets connected to areas spanning point-of-care diagnostics, bio-defense, environmental monitoring, and food safety. This technology will also bring new opportunities to analytical science, particularly in studies that demand the high-throughput characterization of varied chemical moieties, as routinely carried out in the pharmaceutical industry. Further, this work will positively impact efforts to improve healthcare facilities through the development of advanced and low-cost diagnostic tools. The intellectual merit of this project lies in its ability to circumvent multiple limitations of existing nuclear spin polarization technologies through a robust, low-cost platform that leverages recent experimental findings. The technology to be developed introduces a new, laser-assisted route to enhancing the fractional alignment of nuclear spins in a target fluid, thus reducing the analyte's volume, the acquisition time, and the cost and size of the overall NMR system. The proposed approach articulates fluidics and photonic technologies to dynamically polarize fluids exposed to a properly engineered solid-state matrix. A central goal is to engineer the proposed device and conduct initial characterizations of its performance using model target fluids; the anticipated level of polarization is of the order 0.1% to 1% (i.e., orders of magnitude superior than that possible with commercially available magnets). These 'hyperpolarized' fluids can be used directly for inspection, or as a resource to post-polarize other (e.g., light-sensitive) fluidic systems.

这个小型企业创新研究第一阶段项目提出开发一个光流体平台，用于需要增强检测灵敏度的核磁共振（NMR）应用。在美国，NMR占分子光谱市场的最大份额，2013年估计价值为7亿美元，2018年为10亿美元。这项工作所产生的紧凑型便携式系统将应用于现有的、新兴的或与护理点诊断、生物防御、环境监测和食品安全相关的新市场。这项技术也将为分析科学带来新的机遇，特别是在需要高通量表征各种化学部分的研究中，如制药行业中常规进行的那样。此外，这项工作将通过开发先进和低成本的诊断工具，对改善医疗保健设施的努力产生积极影响。该项目的智力价值在于它能够通过利用最新实验结果的强大，低成本平台来规避现有核自旋极化技术的多重限制。该技术的开发引入了一种新的，激光辅助的路线，以提高目标流体中的核自旋的分数对齐，从而减少分析物的体积，采集时间，以及整个NMR系统的成本和尺寸。所提出的方法将流体和光子技术结合起来，动态地将流体暴露在适当设计的固态基质中。中心目标是设计所提出的装置并使用模型目标流体对其性能进行初始表征;预期的极化水平为0.1%至1%的量级（即，数量级优于商业上可获得的磁体的数量级上级）。这些“超极化”流体可直接用于检查，或作为后处理其它流体的资源（例如，光敏）流体系统。