MRI: Acquisition of a Cryogenic Probe and Modern Console for Outstanding NMR Sensitivity to Benefit Research and Education at Cornell University

在主要研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持下，康奈尔大学的Yimon Aye教授及其同事琳达尼科尔森和威廉迪特尔将升级500 MHz NMR光谱仪的控制台，并为此光谱仪获得冷冻探针和自动进样器。该光谱仪将允许在各种领域进行研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。相对于标准NMR探针，低温探针将提供灵敏度的显著增加。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为康奈尔大学本科生和研究生以及未来的女性和少数民族教师进行教学和研究的一个组成部分。它还将用于化学背景差的新生通过强化夏桥课程开设的化学入门课程，其长期目标是让他们留在科学、技术、工程和数学专业。该仪器将在纽约市中心的K-12学生和教师的教育推广计划中展出，其自动进样器实现的上级样品吞吐量将使多核NMR实验首次纳入本科实验室课程。该奖项旨在加强各级研究和教育，特别是在诸如（a）用小分子调节大分子自组装和酶活性;（B）探测调节寿命的化学信号传导机制;（c）追踪改变淀粉样前体蛋白的蛋白水解加工的小分子磷酸化化合物的命运;（d）通过小分子诱导的二聚化研究谷氨酸受体的变构调节;（e）使用石墨烯纳米带和其他纳米结构碳材料的自下而上合成;（f）开发聚合催化剂以制备具有改进性能的聚合物;（g）表征锂基Evans烯醇化物的结构和选择性;（h）表征酰胺钠和烯醇化物的聚集行为;（i）合成苏鲁加毒素和其他复杂天然产物;和（j）表征多金属配位化合物的结构和反应性。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Yimon Aye from Cornell University and colleagues Linda Nicholson and William Dichtel will upgrade the console of a 500 MHz NMR spectrometer and acquire a cryoprobe and autosampler for this spectrometer. This spectrometer will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe will provide a significant increase in sensitivity relative to standard NMR probes. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate and graduate students and future female and minority faculty at Cornell University. It will also be used in the introductory chemistry courses by incoming students with poor chemistry backgrounds through an intensive summer bridge course with a long-term goal of retaining them in science, technology, engineering and mathematics (STEM) majors. The instrument will be featured in educational outreach programs to K-12 students and teachers in central New York, and its superior sample throughput enabled by the automatic sample changer will allow multinuclear NMR experiments to be incorporated into undergraduate laboratory curriculum for the first time.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) modulating macromolecular self-assembly and enzymatic activity with small molecules; (b) probing chemical signaling mechanisms that regulate life span; (c) tracking the fate of small-molecule phosphorylated compounds that alter proteolytic processing of the amyloid precursor protein; (d) studying allosteric modulation of glutamate receptors through small molecule-induced dimerization; (e) using bottom-up synthesis of graphene nanoribbons and other nanostructured carbon materials; (f) developing polymerization catalysts to prepare polymers with improved properties; (g) characterizing the structure and selectivity of lithium-based Evans enolates; (h) characterizing aggregation behavior of sodium amides and enolates; (i) synthesizing surugatoxins and other complex natural products; and (j) characterizing the structure and reactivity of multimetallic coordination compounds.