MRI: Acquisition of a Cryogenic Probe and Modern Console for Outstanding NMR Sensitivity to Benefit Research and Education at Cornell University

MRI：采购低温探头和现代控制台，实现出色的 NMR 灵敏度，有利于康奈尔大学的研究和教育

• 批准号: 1531632
• 负责人: Yimon Aye
• 金额: $ 34.93万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531632&HistoricalAwards=false
• 关键词: MRI; Acquisition; Cryogenic; Probe; Modern

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Yimon Aye from Cornell University and colleagues Linda Nicholson and William Dichtel will upgrade the console of a 500 MHz NMR spectrometer and acquire a cryoprobe and autosampler for this spectrometer. This spectrometer will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe will provide a significant increase in sensitivity relative to standard NMR probes. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate and graduate students and future female and minority faculty at Cornell University. It will also be used in the introductory chemistry courses by incoming students with poor chemistry backgrounds through an intensive summer bridge course with a long-term goal of retaining them in science, technology, engineering and mathematics (STEM) majors. The instrument will be featured in educational outreach programs to K-12 students and teachers in central New York, and its superior sample throughput enabled by the automatic sample changer will allow multinuclear NMR experiments to be incorporated into undergraduate laboratory curriculum for the first time.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) modulating macromolecular self-assembly and enzymatic activity with small molecules; (b) probing chemical signaling mechanisms that regulate life span; (c) tracking the fate of small-molecule phosphorylated compounds that alter proteolytic processing of the amyloid precursor protein; (d) studying allosteric modulation of glutamate receptors through small molecule-induced dimerization; (e) using bottom-up synthesis of graphene nanoribbons and other nanostructured carbon materials; (f) developing polymerization catalysts to prepare polymers with improved properties; (g) characterizing the structure and selectivity of lithium-based Evans enolates; (h) characterizing aggregation behavior of sodium amides and enolates; (i) synthesizing surugatoxins and other complex natural products; and (j) characterizing the structure and reactivity of multimetallic coordination compounds.

在主要研究仪器项目（MRI）和化学研究仪器项目（CRIF）的支持下，康奈尔大学的Yimon Aye教授及其同事Linda Nicholson和William Dichtel将升级一台500 MHz核磁共振光谱仪的控制台，并为该光谱仪购买冷冻探针和自动进样品器。该光谱仪将允许在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及允许对生物学相关物种进行研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。与标准核磁共振探针相比，低温探针将显著提高灵敏度。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为康奈尔大学本科生和研究生以及未来的女性和少数族裔教师的教学和研究的一个组成部分。它还将用于化学背景较差的新生的入门化学课程，通过强化夏季桥梁课程，长期目标是将他们留在科学、技术、工程和数学（STEM）专业。该仪器将在纽约中部的K-12学生和教师的教育推广计划中具有特色，其优越的样品处理量由自动样品转换器实现，将允许多核磁共振实验首次纳入本科实验室课程。该奖项旨在加强各级的研究和教育，特别是在以下领域：(a)调节大分子自组装和小分子酶活性；(b)探索调节寿命的化学信号机制；(c)追踪改变淀粉样前体蛋白蛋白水解过程的小分子磷酸化化合物的命运；(d)通过小分子诱导二聚化研究谷氨酸受体的变构调节；(e)采用自下而上的方法合成石墨烯纳米带等纳米结构碳材料；(f)开发聚合催化剂，制备性能更好的聚合物；(g)表征了锂基埃文斯烯醇酯的结构和选择性；(h)表征酰胺钠和烯醇化钠的聚集行为；(i)合成硫脲毒素和其他复杂天然产物；(j)表征多金属配位化合物的结构和反应性。