Gene Drives: A Deliberative Workshop to Develop Frameworks for Research and Governance February 24-26, 2016

基因驱动：制定研究和治理框架的审议研讨会 2016 年 2 月 24-26 日

• 批准号: 1533990
• 负责人: Jennifer Kuzma
• 金额: $ 5万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1533990&HistoricalAwards=false
• 关键词: Gene; Drives; Deliberative; Workshop; Develop

General Audience SummaryThis award provides funding for a workshop that is to occur over three full days in the early winter of 2015-2016. The topic of the conference is the governance of gene drives. Gene drives are a subset of second generation genetic engineering technologies that are being developed with the aim of moving synthetic gene constructs into wild animal populations to protect, suppress or eliminate them, such as the suppression of mosquitoes that transmit malaria and dengue. Experts from four areas will participate in the workshop: Genetics and molecular biology, ecology and ecological modeling, political economy, and STS (including ethics). The PI plans for there to be equal representation across these areas; experts will include members of academia, practitioners and experts from government, NGOs, and industry. The structure of the workshop will be designed to engage participants in working together to generate analyses and summaries useful for future decision and policy making about gene drives. Following the workshop, papers will be finalized for publication in a special journal edition. A summary article will be published by the program committee that compares issues and system maps across the case studies and summarizes the key findings of the workshop. The program committee will also draft a shorter piece sub mitted for a high profile venue, such as a Nature or Science commentary.Technical Summary The proposed workshop will produce a typology of gene drives for more nuanced and productive conversations about governance. Specifically, participants will develop a draft typology of technologies, purposes, and contexts of gene drives, and a framework of issues and research needs for three key areas: ecological risk analysis, political economy analysis (including governance regimes), and ethical analysis. In order to cover a range of technologies, purposes, and issues, but yet be specific enough for productive dialogue, three case studies will be used to anticipate the social, ecological, economic, and ethical issues associated with gene drives. Integration of the natural and social sciences will be achieved through broad multidisciplinary participation and thinking about the cases and the systems in which they are embedded. Collaborative systems mapping will be used as a tool to assist in the integration of natural, social, and ethical variables, as it has been shown to be effective in creating an environment where complexities and uncertainties can be better seen and understood , and where participants are more willing to open up to alternative perspectives. The combination of the topic, approach, and outputs of the workshop make it unique, and it will contribute to deeper intellectual understanding of gene drives in societal contexts.

本奖项为2015-2016年初冬为期三天的研讨会提供资金。会议的主题是基因驱动的治理。基因驱动是第二代基因工程技术的一个子集，正在开发的第二代基因工程技术的目的是将合成的基因结构转移到野生动物种群中，以保护、抑制或消灭它们，例如抑制传播疟疾和登革热的蚊子。来自四个领域的专家将参加研讨会：遗传学和分子生物学、生态学和生态建模、政治经济学和STS（包括伦理学）。PI计划在这些地区有平等的代表权；专家将包括来自政府、非政府组织和工业界的学术界成员、从业人员和专家。研讨会的结构将被设计成让参与者一起工作，以产生对基因驱动的未来决策和政策制定有用的分析和总结。讲习班结束后，论文将定稿，以便在一个特别的期刊版上发表。计划委员会将发表一篇总结文章，对案例研究中的问题和系统图进行比较，并总结研讨会的主要发现。项目委员会还将起草一篇较短的文章，提交给一个高知名度的场所，如自然或科学评论。提议的研讨会将产生一个基因驱动的类型学，用于关于治理的更细致和富有成效的对话。具体而言，参与者将制定一份基因驱动技术、目的和背景的类型草案，以及三个关键领域的问题和研究需求框架：生态风险分析、政治经济分析（包括治理制度）和伦理分析。为了涵盖一系列技术、目的和问题，但又足够具体，以便进行富有成效的对话，将使用三个案例研究来预测与基因驱动相关的社会、生态、经济和伦理问题。自然科学和社会科学的整合将通过广泛的多学科参与和对案例及其所嵌入的系统的思考来实现。协作系统映射将被用作帮助整合自然、社会和伦理变量的工具，因为它已被证明在创造一个环境方面是有效的，在这个环境中，复杂性和不确定性可以更好地看到和理解，参与者更愿意开放不同的观点。研讨会的主题、方法和成果的结合使其独一无二，它将有助于对社会背景下基因驱动的更深层次的知识理解。