Symptom-specific functional and structural connectivity of the fronto-striatal circuitry in obsessive-compulsive disorder

强迫症中额叶纹状体回路的症状特异性功能和结构连接

• 批准号: 221535930
• 负责人: Professorin Dr. Kathrin Koch
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/221535930?language=en
• 关键词: Symptom; specific; functional; structural; connectivity

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness that is characterized by high symptom heterogeneity. Whereas some patients suffer mainly from contamination fears or washing compulsions, others are affected predominantly by obsessive behaviors such as checking compulsions. Recent studies indicated that established therapies are not equally effective in the different psychopathological subgroups. Moreover, there is increasing evidence showing that the different symptom dimensions may be mediated by partially distinct neural systems and may be associated with symptom-specific alterations in functional and structural connectivity within relevant, mainly fronto-striatal, networks.Thus, a more specific characterization of psychopathological subgroups or symptom dimensions in OCD is sensible and important, both from a diagnostic and etiologic perspective, as well as for therapeutic reasons. Multimodal studies investigating specific functional systems (functional connectivity) and subserving white matter fiber tracts (structural connectivity) with regard to symptom-specific alterations have not been performed in OCD so far. Against this background, the proposed project aims at investigating symptom-specific alterations in functional and structural connectivity in patients with OCD. The study will be focusing on patients with predominantly checking compulsions as well as patients with predominantly contamination fears and washing compulsions. These symptom dimensions have been shown to be relatively independent from each other and to be characterized by high construct validity thus allowing for a reliable discrimination of groups. To this aim, the project will employ neurocognitive paradigms examining decision making under uncertainty, reward processing and cognitive control, i.e. processes involving mainly fronto-striatal networks which are known to be altered in the context of the disorder. Structural connectivity will be determined by means of diffusion tensor imaging (DTI). Specific fiber tracts will be examined using tract-based spatial statistics and probabilistic fiber tracking. Postulated alterations in functional connectivity will be studied with ¿Dynamic Causal Modeling¿ (DCM) and will be related to respective white matter alterations using correlational and voxel-based methods. This multimodal procedure should provide specific information about the pathophysiological substrates underlying alterations in functional and structural connectivity in patients with OCD that allow for a neurobiological differentiation between different symptom dimensions or patient subgroups. Perspectively, the identification of symptom-specific neurofunctional alterations may provide the basis for personalized pharmacological and psychotherapeutic treatment strategies.

强迫症（OCD）是一种严重的精神疾病，其特点是症状高度异质性。有些患者主要受到污染恐惧或清洗强迫症的困扰，而另一些患者则主要受到检查强迫症等强迫行为的影响。最近的研究表明，现有的疗法在不同的精神病理学亚组中并不同样有效。此外，越来越多的证据表明，不同的症状维度可能是由部分不同的神经系统介导的，并且可能与相关网络（主要是额纹状体网络）内功能和结构连接的症状特异性改变有关。因此，从诊断和病因学角度以及治疗角度来看，对强迫症的精神病理学亚组或症状维度进行更具体的表征是明智且重要的。 原因。迄今为止，尚未在强迫症中进行关于特定症状改变的多模态研究，调查特定功能系统（功能连接）和维护白质纤维束（结构连接）。在此背景下，拟议的项目旨在调查强迫症患者功能和结构连接的症状特异性改变。该研究将重点关注主要有检查强迫症的患者以及主要有污染恐惧和清洗强迫症的患者。这些症状维度已被证明是彼此相对独立的，并且具有高结构效度的特征，从而可以可靠地区分群体。为此，该项目将采用神经认知范式来检查不确定性下的决策、奖励处理和认知控制，即主要涉及额纹状体网络的过程，已知这些网络会在疾病的背景下发生改变。结构连通性将通过扩散张量成像（DTI）来确定。将使用基于束的空间统计和概率纤维跟踪来检查特定的纤维束。假定的功能连接变化将通过“动态因果模型”（DCM）进行研究，并将使用相关和基于体素的方法与相应的白质变化相关联。这种多模式程序应提供有关强迫症患者功能和结构连接改变的病理生理学基础的具体信息，从而允许不同症状维度或患者亚组之间的神经生物学差异。从长远来看，症状特异性神经功能改变的识别可能为个性化药理学和心理治疗策略提供基础。

项目成果

Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.

• DOI: 10.1176/appi.ajp.2016.16020201
• 发表时间: 2017-01-01
• 期刊: The American journal of psychiatry
• 作者: Boedhoe PS;Schmaal L;Abe Y;Ameis SH;Arnold PD;Batistuzzo MC;Benedetti F;Beucke JC;Bollettini I;Bose A;Brem S;Calvo A;Cheng Y;Cho KI;Dallaspezia S;Denys D;Fitzgerald KD;Fouche JP;Giménez M;Gruner P;Hanna GL;Hibar DP;Hoexter MQ;Hu H;Huyser C;Ikari K;Jahanshad N;Kathmann N;Kaufmann C;Koch K;Kwon JS;Lazaro L;Liu Y;Lochner C;Marsh R;Martínez-Zalacaín I;Mataix-Cols D;Menchón JM;Minuzzi L;Nakamae T;Nakao T;Narayanaswamy JC;Piras F;Piras F;Pittenger C;Reddy YC;Sato JR;Simpson HB;Soreni N;Soriano-Mas C;Spalletta G;Stevens MC;Szeszko PR;Tolin DF;Venkatasubramanian G;Walitza S;Wang Z;van Wingen GA;Xu J;Xu X;Yun JY;Zhao Q;ENIGMA OCD Working Group;Thompson PM;Stein DJ;van den Heuvel OA
• 通讯作者: van den Heuvel OA

Hypogyrification in obsessive-compulsive disorder

• DOI: 10.1017/s0033291716003202
• 发表时间: 2017-04-01
• 期刊: PSYCHOLOGICAL MEDICINE
• 影响因子: 6.9
• 作者: Rus, O. G.;Reess, T. J.;Koch, K.
• 通讯作者: Koch, K.