Neurobiology and Psychophysiology of Impaired Fear Learning and Extinction Processes in Obsessive-Compulsive Disorder

强迫症中恐惧学习受损和消退过程的神经生物学和心理生理学

• 批准号: 314271828
• 负责人: Professorin Dr. Kathrin Koch
• 金额: --
• 依托单位: Max-Planck-Institut für Psychiatrie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/314271828?language=en
• 关键词: Neurobiology; Psychophysiology; Impaired; Fear; Learning

Fear and anxiety are core characteristics of obsessive-compulsive disorder (OCD) which typically precede and accompany both obsessions as well as compulsions and thus constitute the driving force behind OCD symptomatology. There is increasing evidence for altered activity in core regions of the fear circuitry in OCD, and fear learning as well as fear extinction can be assumed to constitute central mechanisms of the disorder. These mechanisms should be investigated in order to increase our understanding of the processes involved in the development and/or maintenance of OCD psychopathology. Moreover, studying fear learning and extinction in OCD may help to enhance therapeutic efficacy considering that cognitive behavioral therapies used to treat obsessions and compulsions in OCD are typically extinction-based. However, little is known about the mechanisms subserving fear conditioning, extinction and extinction retention in OCD. First evidence suggests that extinction recall might be disrupted in OCD. Against this background, the planned project aims at investigating the neural and psychophysiological correlates of fear conditioning, extinction, and extinction retention in OCD using refined psychophysiological readouts (including startle electromyography and pupillometry), an fMRI fear reversal task and an anxiety provocation task to elucidate which mechanisms may be altered in association with these processes in patients with OCD. Moreover, using the method of actigraphy sleep and circadian rhythms will be explored as sleep is known to be related to emotional memory consolidation and may therefore help to disentangle the potential alterations in extinction recall in patients with OCD.

恐惧和焦虑是强迫症（OCD）的核心特征，它们通常先于强迫症和强迫症并伴随两者，因此构成了强迫症治疗学背后的驱动力。越来越多的证据表明，强迫症恐惧回路核心区域的活动发生了变化，恐惧学习和恐惧消退可以被认为是构成这种疾病的中心机制。这些机制应进行调查，以增加我们的了解过程中涉及的发展和/或维持强迫症的精神病理学。此外，研究强迫症中的恐惧学习和消退可能有助于提高治疗效果，因为用于治疗强迫症中的强迫症和强迫症的认知行为疗法通常是基于预防的。然而，对强迫症中恐惧条件反射、消退和消退保持的机制知之甚少。第一个证据表明，灭绝回忆可能会在强迫症中被破坏。在此背景下，计划中的项目旨在调查神经和心理生理学相关的恐惧条件反射，灭绝和灭绝保持在强迫症使用精细的心理生理学读数（包括惊吓肌电图和瞳孔），功能磁共振成像恐惧逆转任务和焦虑激发任务，以阐明哪些机制可能会改变与强迫症患者的这些过程。此外，使用活动记录睡眠和昼夜节律的方法将被探索，因为已知睡眠与情绪记忆巩固有关，因此可能有助于解开强迫症患者的消退回忆的潜在变化。

项目成果

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

• DOI: 10.1038/s41562-019-0659-6
• 发表时间: 2019-09-01
• 期刊: NATURE HUMAN BEHAVIOUR
• 影响因子: 29.9
• 作者: de Lange, Siemon C.;Scholtens, Lianne H.;van den Heuvel, Martijn P.
• 通讯作者: van den Heuvel, Martijn P.

An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.

• DOI: 10.1002/hbm.24972
• 发表时间: 2022-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: van den Heuvel OA;Boedhoe PSW;Bertolin S;Bruin WB;Francks C;Ivanov I;Jahanshad N;Kong XZ;Kwon JS;O'Neill J;Paus T;Patel Y;Piras F;Schmaal L;Soriano-Mas C;Spalletta G;van Wingen GA;Yun JY;Vriend C;Simpson HB;van Rooij D;Hoexter MQ;Hoogman M;Buitelaar JK;Arnold P;Beucke JC;Benedetti F;Bollettini I;Bose A;Brennan BP;De Nadai AS;Fitzgerald K;Gruner P;Grünblatt E;Hirano Y;Huyser C;James A;Koch K;Kvale G;Lazaro L;Lochner C;Marsh R;Mataix-Cols D;Morgado P;Nakamae T;Nakao T;Narayanaswamy JC;Nurmi E;Pittenger C;Reddy YCJ;Sato JR;Soreni N;Stewart SE;Taylor SF;Tolin D;Thomopoulos SI;Veltman DJ;Venkatasubramanian G;Walitza S;Wang Z;Thompson PM;Stein DJ;ENIGMA-OCD working group
• 通讯作者: ENIGMA-OCD working group

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

• DOI: 10.1016/j.biopsych.2019.04.022
• 发表时间: 2020-06-15
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Kong, Xiang-Zhen;Boedhoe, Premika S. W.;Francks, Clyde
• 通讯作者: Francks, Clyde