Planning Grant: Collaborative Research: I/UCRC for Building Reliable Advances and Innovation in Neurotechnology (BRAIN)

规划资助：合作研究：I/UCRC 建立神经技术的可靠进步和创新 (BRAIN)

• 批准号: 1540006
• 负责人: Jose Contreras-Vidal
• 金额: $ 1.15万
• 依托单位: University of Houston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1540006&HistoricalAwards=false
• 关键词: Planning; Grant; Collaborative; Research; UCRC

This project will bring together teams from Arizona State University and University of Houston in collaboration with industry partners to establish a research center, called BRAIN (Building Reliable Advances and Innovation in Neurotechnology) that will overcome several innovation challenges in neurotechnology: 1) The pace of innovation exceeds the rate of evaluation for acceptable performance; 2) Standards and regulatory science for rigorous validation of safety, efficacy, and long-term reliability are missing; 3) Lack of open access to technologies and synergistic collaborations impede transfer of novel technologies to the market; and 4) Current technologies are costly, limiting their utility in enhancing treatment and overcoming physical disabilities. In addition, the BRAIN Center, through the efforts of the Education/Outreach coordinator, will work to rectify under-representation in the science, technology, engineering, and math (STEM) fields by broadening new participation and retaining current participants in STEM through 1) newly initiated K-12 outreach programs that expose aspiring STEM participants to innovative neurotechnologies, 2) undergraduate internship program within the Center that targets specific student organizations (e.g., Society of Mexican-American Engineers and Scientists, Society of Women Engineers), and 3) focusing on problems in the neurological space that affect underrepresented groups disproportionately. The Center's vision is a synergistic, interdisciplinary approach to the development and validation of affordable patient-centered technologies, and use of those technologies in understanding neural systems. BRAIN will leverage expertise in neural, cognitive and rehabilitation engineering, robotics, clinical testing, and reverse-translational research at Arizona State University (ASU) and the University of Houston (UH) to (a) enhance the rate of development and empirical validation of new technologies through partnerships with industry leaders and other strategic partners; (b) develop standards and test technologies in human and non-human models using a multi-scale approach ranging from single neurons to organismal systems; (c) characterize novel and innovative technologies such as biosensors and quantitative analysis tools for systems and behaviors; (d) evaluate the impact of these technologies on quality of life; and (e) reduce the cost burden of neural technologies on hospitals and families.

该项目将汇集亚利桑那州立大学和休斯敦大学的团队，与行业合作伙伴合作建立一个名为 BRAIN（在神经技术领域建立可靠的进步和创新）的研究中心，该中心将克服神经技术领域的几个创新挑战：1）创新的速度超过了可接受性能的评估速度； 2）缺乏严格验证安全性、有效性和长期可靠性的标准和监管科学； 3）缺乏技术的开放获取和协同合作阻碍了新技术向市场的转移； 4) 目前的技术成本高昂，限制了其在加强治疗和克服身体残疾方面的效用。此外，BRAIN 中心将在教育/外展协调员的努力下，通过 1) 新启动的 K-12 外展计划，让有抱负的 STEM 参与者接触创新的神经技术，2) 中心内针对特定学生组织的本科生实习计划，扩大新的参与并留住 STEM 的现有参与者，从而努力纠正科学、技术、工程和数学 (STEM) 领域代表性不足的问题 （例如，墨西哥裔美国工程师和科学家协会、女工程师协会），3）重点关注对代表性不足的群体造成不成比例影响的神经学领域的问题。该中心的愿景是采用协同、跨学科的方法来开发和验证负担得起的以患者为中心的技术，并利用这些技术来理解神经系统。 BRAIN 将利用亚利桑那州立大学 (ASU) 和休斯顿大学 (UH) 在神经、认知和康复工程、机器人、临床测试和逆翻译研究方面的专业知识，以 (a) 通过与行业领导者和其他战略合作伙伴的合作，提高新技术的开发速度和实证验证； (b) 使用从单个神经元到生物系统的多尺度方法，制定人类和非人类模型的标准和测试技术； (c) 描述新颖和创新技术的特征，例如生物传感器和系统和行为的定量分析工具； (d) 评估这些技术对生活质量的影响； (e) 减轻神经技术对医院和家庭的成本负担。