2013 International Workshop on Clinical Brain-Neural Machine Interface Systems

在非人类灵长类动物和人类中使用微电极阵列解码大脑活动方面取得的突破，以及在人类中使用无创脑电图，现在可以相对准确地预测上肢和下肢的运动。因此，现在正在开发外周神经系统接口来可靠地控制假肢。然而，将这些技术带给最终用户的转化工作面临着重要的监管、科学、工程、临床、伦理和财务挑战，利益相关者需要更好地理解这些挑战。这是对临床脑神经-机器接口系统（简称BMI）国际研讨会的部分支持，该研讨会旨在确定和讨论当前的挑战和潜在的解决方案，从而导致基于临床/家庭应用的神经活动接口系统的开发和部署。会议将由休斯顿大学组织，于2013年2月24日至27日在德克萨斯医学中心（休斯顿）的卫理公会医院研究所（TMHRI）举行。本次研讨会将汇集来自BMI研究前沿的专家演讲者（包括初级和高级级别）和讨论家、康复临床医生、神经学家、神经外科医生、工程师、计算机科学家、神经科学家、联邦机构的项目经理、工业部门的代表、最终用户和其他利益相关者在学术环境中进行讨论和互动，目标是制定战略计划（“路线图”），将BMI系统从实验室带到诊所/家庭。探讨的主题将包括：需要bmi（“市场”）的临床需求和应用“拉动”是什么；揭示基本机制和验证BMI系统技术的最佳方法是什么；影响bmi临床应用的科学、工程和监管挑战是什么，以及潜在的解决方案；可以从这种协同机器人技术中受益的患者的需求是什么？如何解决使用身体质量指数系统来增强身体/大脑的潜在伦理问题；以及如何培养神经和康复工程方面的下一代学生。更广泛的影响：总结研讨会发现的“路线图”将提交给《神经修复学前沿》（Frontiers in Neuroprosthetics），这是一本致力于BMI系统的一流电子开放获取期刊。为此，将邀请来自选定大学科学写作项目的教师和研究生撰写博客，并在研讨会期间撰写小组互动总结和最后的小组简报；这些由讨论者编辑的摘要将作为与会者达成的协商一致意见的草稿（少数人的意见也将包括在内）。该路线图将为联邦机构的项目经理提供指导，以开发资金机会和支持机制，以加强和加速临床BMI系统的部署。研讨会组织者将积极从代表性不足的群体（包括妇女和少数民族）和各机构招募参与者，以确保听到他们的声音。

Breakthroughs in the decoding of brain activity using microelectrode arrays in non-human primates and humans, and noninvasive electroencephalography in humans, now enable relatively accurate predictions of upper and lower limb movements. As a consequence, peripheral nervous system interfaces are now being developed to reliably control prosthetic limbs. However, translational efforts to bring these technologies to end-users are confronted with important regulatory, scientific, engineering, clinical, ethical, and financial challenges that stakeholders need to better understand. This is partial support for an International Workshop on Clinical Brain Neural-Machine Interface Systems (BMI, for short) intended to identify and discuss current challenges and potential solutions leading to the development and deployment of interface systems based on neural activity in clinical/home applications. The meeting will be organized by the University of Houston and held at The Methodist Hospital Research Institute (TMHRI) in the Texas Medical Center (Houston), on February 24-27, 2013. The workshop will bring together expert speakers (at both junior and senior levels) and discussants representing the forefront of BMI research, rehabilitation clinicians, neurologists, neurosurgeons, engineers, computer scientists, neuroscientists, program managers at federal agencies, representatives of the industrial sector, end-users and other stakeholders for discussions and interaction in an academic setting with the goal of developing a strategic plan ("roadmap") to bring BMI systems out of the lab and into the clinic/home. Topics to be explored will include: what are the clinical needs and application "pulls" that require BMIs (the "market"); what is the best approach for uncovering basic mechanisms and validating BMI systems technology; what are the scientific, engineering and regulatory challenges that affect clinical use of BMIs, and potential solutions; what are the needs of patients who could benefit from this co-robot technology; how to address potential ethical concerns regarding the use of BMI systems to enhance the body/brain; and how to train the next generation of students in neural and rehabilitation engineering.Broader Impacts: A "roadmap" summarizing the findings of the workshop will be submitted for peer-review to Frontiers in Neuroprosthetics, a first-tier electronic open access journal devoted to BMI systems. To this end, faculty and graduate students from selected university science writing programs will be invited to blog and write summaries of the group interactions and final group briefings during the workshop; these summaries, edited by the discussants, will serve as drafts of the consensus attained by the participants (minority opinions will also be included). This roadmap will serve as a guide to program managers at federal agencies to develop funding opportunities and support mechanisms to enhance and accelerate the deployment of clinical BMI systems. The workshop organizers will actively recruit participants from under-represented groups, including women and minorities, and across institutions, to ensure that their voice is heard.