2015 Molecular Mechanisms in Evolution Gordon Research Conference held 28 Jun - 3 Jul 2015 at Stonehill College, Easton MA.

2015年进化分子机制戈登研究会议于2015年6月28日至7月3日在马萨诸塞州伊斯顿斯通希尔学院举行。

基本信息

  • 批准号:
    1540359
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-01 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

Quantitative approaches such as mathematical modeling, high-throughput phenotyping combined with technology development may yet yield a united theory of biology and life. The "modern synthesis" of the early twentieth century predated the molecular biology revolution and the genomics era. Although many of the assumptions and predictions of traditional population genetics have proven correct, others have to be modified due to new discoveries such as non-genetic, protein and RNA-based inheritance and stress-inducible mutations. Likewise, researchers in the fields of molecular biology, genomics, and medicine are often unacquainted with population genetics theory. This meeting is aimed at the growing numbers of investigators attempting to unite these formerly disparate fields and to learn from physicists how to arrive at universal principles. This meeting aims to provide a home and community for researchers involved in this ongoing, cross-disciplinary endeavor. The Gordon Research Conference (GRC) program includes invited and contributed oral and poster presentations by both younger and more established researchers, focusing on the best emerging science in the field.The second meeting of the new Gordon Research Conference Molecular Mechanisms in Evolution, June 28th-July 3rd, 2015 at Stonehill College, Easton, MA breaks new ground by focusing on the mechanistic understanding of how genetic and epigenetic variation arises, especially in response to environmental stress, and to which extent this variation generates phenotypic diversity, shapes evolution, and contributes to disease. The meeting sessions address a wide range of topics, including discussions of the constraints that cell biology and stochasticity pose for non-traditional mechanisms of inheritance, insights garnered from experiments in the laboratory, mechanisms of coding and regulation highlighting the unexpected plasticity of genomes. The meeting will discuss how mechanistic knowledge could be used to predict and arrest inheritance processes in infectious diseases and cancer. The GRC will promote international and national collaboration between physicists and biologists of diverse disciplines to promote systematic and quantitative analyses of biological processes, intensified theory building and deeper understanding of basic biology. This meeting will provide networking opportunities, inspiration and connections for young scientists, mentoring, and perspectives on cutting-edge new research for young participants at a critical stage in their careers. The requested funds will be used to defray the costs of a diverse group of graduate students, postdocs, new investigators, women, and minority participants.This project is being jointly supported by the Physics of Living Systems program in the Division of Physics and the Genetic Mechanisms Program in the Division of Molecular and Cellular Biosciences.
定量方法,如数学建模,高通量表型与技术发展相结合,可能会产生生物学和生命的统一理论。20世纪早期的“现代合成”早于分子生物学革命和基因组学时代。尽管传统种群遗传学的许多假设和预测已被证明是正确的,但由于非遗传、蛋白质和rna遗传以及应激诱导突变等新发现,其他假设和预测必须加以修改。同样,分子生物学、基因组学和医学领域的研究人员往往不熟悉群体遗传学理论。这次会议的目的是让越来越多的研究人员试图将这些以前不同的领域结合起来,并向物理学家学习如何得出普遍的原理。本次会议旨在为参与这一正在进行的跨学科努力的研究人员提供一个家和社区。戈登研究会议(GRC)计划包括邀请年轻和更成熟的研究人员进行口头和海报演讲,重点关注该领域最好的新兴科学。2015年6月28日至7月3日,在马萨诸塞州伊斯顿的斯通希尔学院举行的新戈登研究会议分子进化机制第二次会议开辟了新的领域,重点关注遗传和表观遗传变异如何产生的机制理解,特别是在对环境压力的反应中,以及这种变异在多大程度上产生表型多样性,塑造进化,并导致疾病。会议讨论了广泛的主题,包括讨论细胞生物学和随机性对非传统遗传机制的限制,从实验室实验中获得的见解,强调基因组意想不到的可塑性的编码和调控机制。会议将讨论如何利用机械知识来预测和控制传染病和癌症的遗传过程。GRC将促进不同学科的物理学家和生物学家之间的国际和国内合作,以促进生物过程的系统和定量分析,加强理论建设和深入了解基础生物学。本次会议将为年轻科学家提供交流机会、灵感和联系、指导,并为处于职业生涯关键阶段的年轻参与者提供前沿新研究的观点。申请的资金将用于支付研究生、博士后、新研究者、女性和少数族裔参与者等不同群体的费用。该项目由物理系的生命系统物理学项目和分子与细胞生物科学系的遗传机制项目共同支持。

项目成果

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Christine Queitsch其他文献

Christine Queitsch的其他文献

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{{ truncateString('Christine Queitsch', 18)}}的其他基金

PlantSynBio: Deciphering the grammar of crop regulatory DNA for precise engineering of gene expression
PlantSynBio:破译作物调控 DNA 的语法以实现基因表达的精确工程
  • 批准号:
    2240888
  • 财政年份:
    2023
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Standard Grant
REU Site: Big Data Science and Science Communication
REU 网站:大数据科学与科学传播
  • 批准号:
    1950024
  • 财政年份:
    2020
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Standard Grant
RESEARCH-PGR: Enhancer discovery and design in agriculturally important crop plants
研究-PGR:重要农业作物的增强剂发现和设计
  • 批准号:
    1748843
  • 财政年份:
    2018
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Continuing Grant
REU Site: Discoveries in Genomics and Proteomics
REU 网站:基因组学和蛋白质组学的发现
  • 批准号:
    1659680
  • 财政年份:
    2017
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Continuing Grant
Using the Plant Heat Stress Response to Probe Genome-wide Regulatory Landscapes for Functional Relevance
利用植物热应激反应来探测全基因组调控景观的功能相关性
  • 批准号:
    1516701
  • 财政年份:
    2015
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Standard Grant
EAGER: RNA Polymerase V as a Novel Capacitor of Phenotypic Variation in Arabidopsis thalian
EAGER:RNA 聚合酶 V 作为拟南芥表型变异的新型电容器
  • 批准号:
    1242744
  • 财政年份:
    2012
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Standard Grant

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