NSF Ideas Lab - Cracking the Olfactory Code
NSF 创意实验室 - 破解嗅觉密码
基本信息
- 批准号:1546749
- 负责人:
- 金额:$ 19.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-06-15 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Olfaction is an evolutionarily primitive sense critical for survival across the animal kingdom - finding food, searching for mates, or avoiding predation all depend on detecting, identifying, and discriminating odors. Although early steps in olfactory processing are relatively well understood, significant gaps remain in our understanding of higher-order odor representations and processing during on-going behavior. Deciphering the operating principles of olfaction requires the development of innovative and integrative approaches that combine novel theoretical frameworks, improved mathematical models, and novel behavioral paradigms across the phylogenetic spectrum, experimental methodologies, and engineering principles. The objectives of this 5-day workshop, a so-called "Ideas Lab", is to address this challenge by bringing together researchers from diverse scientific backgrounds to engender fresh thinking and innovative approaches that will transform understanding of olfactory processing in behavioral contexts while spawning new opportunities to elucidate the general nature of sensory representations in the brain. The participants will work collaboratively to develop and hone novel ideas about and approaches to investigate olfactory processing, and then use these ideas and approaches to develop multidisciplinary research projects that contain genuinely innovative and potentially transformative investigations on olfactory coding. The organizers will make a strong effort to invite women, members of underrepresented groups, and investigators at all academic levels as workshop participants. Participants will include 10-15 quantitative researchers and 15-20 neuroscientists. An integral aspect of the workshop is extensive cross-disciplinary interaction, which will be facilitated by five leading scientists from key disciplines who have agreed to serve as mentors and will guide the project development process. Importantly, this workshop is part of a concerted effort to coordinate and align interagency priorities to accomplish the goals of the BRAIN Initiative. The workshop is anticipated to result in the development of highly innovative research proposals that integrate theoretical and computational approaches with neuroscience toward the goal of elucidating the nature of olfactory processing and sensory representations in the brain in general.
嗅觉是一种进化上的原始感觉,对整个动物王国的生存至关重要-寻找食物,寻找配偶或避免捕食都依赖于检测,识别和辨别气味。虽然嗅觉加工的早期步骤相对较好地理解,但我们对高阶气味表征和持续行为过程中的加工的理解仍然存在重大差距。破译嗅觉的工作原理需要发展创新和综合的方法,结合联合收割机新的理论框架,改进的数学模型,并在系统发育谱,实验方法和工程原理的新的行为范式。这个为期5天的研讨会的目标,所谓的“想法实验室”,是通过汇集来自不同科学背景的研究人员来应对这一挑战,以产生新的思维和创新方法,这些方法将改变对行为环境中嗅觉处理的理解,同时产生新的机会来阐明大脑中感官表征的一般性质。参与者将共同努力,开发和磨练有关嗅觉处理的新想法和方法,然后使用这些想法和方法开发多学科研究项目,其中包含对嗅觉编码的真正创新和潜在变革性研究。组织者将大力邀请女性、代表性不足群体的成员以及各个学术水平的研究人员作为研讨会的参与者。参与者将包括10-15名定量研究人员和15-20名神经科学家。讲习班的一个组成部分是广泛的跨学科互动,来自关键学科的五位顶尖科学家将为这一互动提供便利,他们同意担任导师,并将指导项目开发过程。重要的是,这次研讨会是协调和调整机构间优先事项以实现BRAIN倡议目标的协同努力的一部分。该研讨会预计将导致高度创新的研究提案的发展,将理论和计算方法与神经科学相结合,以阐明嗅觉处理和感觉表征在大脑中的本质。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Herbert Levine其他文献
Decoding leader cells in collective cancer invasion
集体癌症侵袭中对领导细胞的解码
- DOI:
10.1038/s41568-021-00376-8 - 发表时间:
2021-07-08 - 期刊:
- 影响因子:66.800
- 作者:
Samuel A. Vilchez Mercedes;Federico Bocci;Herbert Levine;José N. Onuchic;Mohit Kumar Jolly;Pak Kin Wong - 通讯作者:
Pak Kin Wong
Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer
解码癌症中代谢与上皮间质转化的耦合决策
- DOI:
10.1038/s41416-021-01385-y - 发表时间:
2021-04-15 - 期刊:
- 影响因子:6.800
- 作者:
Dongya Jia;Jun Hyoung Park;Harsimran Kaur;Kwang Hwa Jung;Sukjin Yang;Shubham Tripathi;Madeline Galbraith;Youyuan Deng;Mohit Kumar Jolly;Benny Abraham Kaipparettu;José N. Onuchic;Herbert Levine - 通讯作者:
Herbert Levine
Effects of Input Fluctuations on the Statistical Dynamics of a Biochemical Switch
- DOI:
10.1016/j.bpj.2011.11.869 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Bo Hu;David A. Kessler;Wouter-Jan Rappel;Herbert Levine - 通讯作者:
Herbert Levine
Activity dependent modulation of synaptic transmission by presynaptic calcium stores: A dichotomy of short-term depression and facilitation
- DOI:
10.1186/1471-2202-14-s1-p351 - 发表时间:
2013-07-08 - 期刊:
- 影响因子:2.300
- 作者:
Suhita Nadkarni;Thomas Bartol;Herbert Levine;Terrence Sejnowski - 通讯作者:
Terrence Sejnowski
Machine learning meets physics: A two-way street.
机器学习与物理学的结合:一条双向路。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:11.1
- 作者:
Herbert Levine;Yuhai Tu - 通讯作者:
Yuhai Tu
Herbert Levine的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Herbert Levine', 18)}}的其他基金
DMS/NIGMS 2: Regulation of Cellular Stemness during the Epithelial-Mesenchymal Transition (EMT)
DMS/NIGMS 2:上皮-间质转化 (EMT) 期间细胞干性的调节
- 批准号:
2245957 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Collaborative Research: International Physics of Living Systems Graduate Research Network
合作研究:国际生命系统物理学研究生研究网络
- 批准号:
2013949 - 财政年份:2021
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Spatial Patterning in the Progressing Tumor - The Role of Notch
进展性肿瘤中的空间模式——Notch 的作用
- 批准号:
1935762 - 财政年份:2019
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Ideas Lab Cracking the Olfactory Code: Followup PI Meeting (May 22, 2017); Arlington, VA
创意实验室破解嗅觉密码:后续 PI 会议(2017 年 5 月 22 日);
- 批准号:
1741669 - 财政年份:2017
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Towards the design of Synthetic Cells
走向合成细胞的设计
- 批准号:
1748208 - 财政年份:2017
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Workshop: Systems and Synthetic Biology for Designing Rational Cancer Immunotherapies; October 6-8, 2016, Tysons Corner, Virginia
研讨会:设计合理癌症免疫疗法的系统和合成生物学;
- 批准号:
1655161 - 财政年份:2016
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Spatial Patterning in the Progressing Tumor - The Role of Notch
进展性肿瘤中的空间模式——Notch 的作用
- 批准号:
1605817 - 财政年份:2016
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Conference: Dynamics Days 2015, January 9-11, 2015, Center for Theoretical Biological Physics, Houston, Texas
会议:2015 年动力学日,2015 年 1 月 9-11 日,理论生物物理中心,德克萨斯州休斯顿
- 批准号:
1503986 - 财政年份:2015
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Physics of Wear, Tear, Aging and Failure in Living and Nonliving Systems Conference
生命和非生命系统中的磨损、撕裂、老化和故障物理学会议
- 批准号:
1544018 - 财政年份:2015
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Workshop: Connecting the Biological and Physical Principles of Mammalian Aging; Arlington, VA; May 15-16, 2014
研讨会:连接哺乳动物衰老的生物学和物理原理;
- 批准号:
1442065 - 财政年份:2014
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
相似海外基金
Collaborative Research: Ideas Lab: ETAUS Meshed Observations of THE Remote Subsurface with Heterogeneous Intelligent Platforms (MOTHERSHIP)
合作研究:创意实验室:ETAUS 通过异构智能平台对远程地下进行网格观测 (MOTHERSHIP)
- 批准号:
2322056 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Collaborative Research: Ideas Lab: ETAUS Meshed Observations of THE Remote Subsurface with Heterogeneous Intelligent Platforms (MOTHERSHIP)
合作研究:创意实验室:ETAUS 通过异构智能平台对远程地下进行网格观测 (MOTHERSHIP)
- 批准号:
2322055 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Collaborative Research: Ideas Lab: The Role of Extracellular RNA in Intercellular and Interkingdom Communication
合作研究:创意实验室:细胞外 RNA 在细胞间和王国间通讯中的作用
- 批准号:
2243537 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: Rational Design of Noncoding RNA for Epigenetic Signal Amplification
合作研究:创意实验室:用于表观遗传信号放大的非编码 RNA 的合理设计
- 批准号:
2243665 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: RNA-encoded Molecular Memory (REMM)
合作研究:创意实验室:RNA 编码的分子记忆 (REMM)
- 批准号:
2243700 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: RNA-encoded Molecular Memory (REMM)
合作研究:创意实验室:RNA 编码的分子记忆 (REMM)
- 批准号:
2243698 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: The Role of Extracellular RNA in Intercellular and Interkingdom Communication
合作研究:创意实验室:细胞外 RNA 在细胞间和王国间通讯中的作用
- 批准号:
2243532 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: Rational Design of Noncoding RNA for Epigenetic Signal Amplification
合作研究:创意实验室:用于表观遗传信号放大的非编码 RNA 的合理设计
- 批准号:
2243667 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Standard Grant
Collaborative Research: Ideas Lab: Smarter Microbial Observatories for Realtime ExperimentS (SMORES)
合作研究:创意实验室:用于实时实验的智能微生物观测站 (SMORES)
- 批准号:
2321651 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant
Collaborative Research: Ideas Lab: ETAUS Meshed Observations of THE Remote Subsurface with Heterogeneous Intelligent Platforms (MOTHERSHIP)
合作研究:创意实验室:ETAUS 通过异构智能平台对远程地下进行网格观测 (MOTHERSHIP)
- 批准号:
2322058 - 财政年份:2023
- 资助金额:
$ 19.66万 - 项目类别:
Continuing Grant