NSF Ideas Lab - Cracking the Olfactory Code

NSF 创意实验室 - 破解嗅觉密码

• 批准号: 1546749
• 负责人: Herbert Levine
• 金额: $ 19.66万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1546749&HistoricalAwards=false
• 关键词: NSF; Ideas; Lab; Cracking; Olfactory

Olfaction is an evolutionarily primitive sense critical for survival across the animal kingdom - finding food, searching for mates, or avoiding predation all depend on detecting, identifying, and discriminating odors. Although early steps in olfactory processing are relatively well understood, significant gaps remain in our understanding of higher-order odor representations and processing during on-going behavior. Deciphering the operating principles of olfaction requires the development of innovative and integrative approaches that combine novel theoretical frameworks, improved mathematical models, and novel behavioral paradigms across the phylogenetic spectrum, experimental methodologies, and engineering principles. The objectives of this 5-day workshop, a so-called "Ideas Lab", is to address this challenge by bringing together researchers from diverse scientific backgrounds to engender fresh thinking and innovative approaches that will transform understanding of olfactory processing in behavioral contexts while spawning new opportunities to elucidate the general nature of sensory representations in the brain. The participants will work collaboratively to develop and hone novel ideas about and approaches to investigate olfactory processing, and then use these ideas and approaches to develop multidisciplinary research projects that contain genuinely innovative and potentially transformative investigations on olfactory coding. The organizers will make a strong effort to invite women, members of underrepresented groups, and investigators at all academic levels as workshop participants. Participants will include 10-15 quantitative researchers and 15-20 neuroscientists. An integral aspect of the workshop is extensive cross-disciplinary interaction, which will be facilitated by five leading scientists from key disciplines who have agreed to serve as mentors and will guide the project development process. Importantly, this workshop is part of a concerted effort to coordinate and align interagency priorities to accomplish the goals of the BRAIN Initiative. The workshop is anticipated to result in the development of highly innovative research proposals that integrate theoretical and computational approaches with neuroscience toward the goal of elucidating the nature of olfactory processing and sensory representations in the brain in general.

嗅觉是一种进化上的原始感觉，对整个动物王国的生存至关重要——寻找食物、寻找配偶或避免捕食都依赖于检测、识别和辨别气味。尽管嗅觉处理的早期步骤相对较好地被理解，但我们对持续行为过程中的高阶气味表征和处理的理解仍然存在重大差距。破译嗅觉的工作原理需要开发创新和综合的方法，将新颖的理论框架、改进的数学模型和跨系统发育谱、实验方法和工程原理的新颖的行为范式结合起来。这个为期 5 天的研讨会（即所谓的“想法实验室”）的目标是应对这一挑战，将来自不同科学背景的研究人员聚集在一起，产生新的思维和创新方法，从而改变对行为环境中嗅觉处理的理解，同时产生新的机会来阐明大脑中感觉表征的一般性质。参与者将共同开发和磨练有关嗅觉处理研究的新想法和方法，然后利用这些想法和方法开发多学科研究项目，其中包含对嗅觉编码的真正创新和潜在变革性的研究。组织者将大力邀请女性、代表性不足群体的成员以及各级学术研究人员作为研讨会参与者。参与者将包括 10-15 名定量研究人员和 15-20 名神经科学家。研讨会的一个组成部分是广泛的跨学科互动，这将由来自关键学科的五位顶尖科学家推动，他们同意担任导师并指导项目开发过程。重要的是，本次研讨会是协调和调整机构间优先事项以实现 BRAIN 计划目标的共同努力的一部分。该研讨会预计将产生高度创新的研究提案，将理论和计算方法与神经科学相结合，以期阐明大脑中嗅觉处理和感觉表征的本质。