Phase II CREST Interdisciplinary Nanotoxicity Center

二期CREST跨学科纳米毒性中心

• 批准号: 1547754
• 负责人: Jerzy Leszczynski
• 金额: $ 300万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1547754&HistoricalAwards=false
• 关键词: Phase; II; CREST; Interdisciplinary; Nanotoxicity

Interdisciplinary Nanotoxicity CenterWith National Science Foundation support, Jackson State University will continue development of the Interdisciplinary Nanotoxicity Center. The Center goal is to enhance knowledge of basic properties and environmental characteristics, toxicity, and applications of nanomaterials. There is a compelling need for studying potential toxicity of nanomaterials and advancing efficient, fast and inexpensive computational approaches to predict toxicity of new species. Understanding of structures, characteristics and biological activities of man-made nanomaterials is critical to prediction of their impacts on the environment and human health. Nanoparticle exposure is common, but short- and long-term exposure effects are currently not fully understood, especially since the primary and agglomerate sizes, surface area, and the characteristics of the surface play such important roles. Conversely, nanotechnology can also be used to create new nanomedicines, sensors, pollutant filters and catalysts with important societal benefits.The Interdisciplinary Nanotoxicity Center focuses on two research subprojects: addressing nanomaterials discovery and deployment. Subproject 1 focuses on multifunctional nanoparticles and their model counterparts: structures, properties, interaction with environment and applications. The aim of this project is to systematically study structure, energetics and optics of metal and semiconductor nanoparticles and their bioconjugates in various environments. Multifunctional environmental safe magnetic core-plasmonic shell nanopaticle based assay for the detection of toxic pathogens selectively from water will be designed and developed, and the possible use of multifunctional nanoparticles for selective removal of toxic pathogens from drinking water is investigated. Subproject 2 investigates toxicity of nanoparticles as a function of environmental factors: experimental studies and computational modeling to include different aspects of the development and production of nanomaterials and investigation of their toxicity. The overarching goal is to develop an operational model for directing production of green metal oxide nanoparticles and to conduct in vitro and in vivo toxicological studies under selected environmental conditions by using engineered metal oxide nanoparticles of controlled size and shape. In addition, computational studies are carried out to develop reliable computational models effective for prediction of physico-chemical characteristics and toxicity of nanomaterials. Both research areas are strongly interconnected and designed to enhance knowledge of basic properties and environmental characteristics, toxicity, and applications of nanomaterials. The Center utilizes the Universal Design for Learning model to maximize learning outputs of diverse student populations.

杰克逊州立大学的国家科学基金会支持跨学科的纳米毒性中心将继续发展跨学科纳米毒性中心。 中心目标是增强对纳米材料的基本特性和环境特征，毒性和应用的了解。迫切需要研究纳米材料的潜在毒性，并提高有效，快速，廉价的计算方法来预测新物种的毒性。了解人造纳米材料的结构，特征和生物学活动对于预测其对环境和人类健康的影响至关重要。纳米颗粒的暴露是常见的，但是目前尚未完全了解短期和长期暴露效应，尤其是因为主要和团聚的大小，表面积，表面积以及表面的特征起着如此重要的作用。相反，纳米技术还可以用来创建具有重要社会益处的新纳米药物，传感器，污染物过滤器和催化剂。跨学科的纳米毒性中心侧重于两个研究子项目：解决纳米材料的发现和部署。子标记1的重点是多功能纳米颗粒及其模型对应物：结构，属性，与环境和应用的相互作用。该项目的目的是在各种环境中系统地研究金属和半导体纳米颗粒及其生物缀合物的结构，能量和光学。将设计和开发多功能环境安全磁芯壳纳米纳米纳米纳米纳米纳米纳米纳米纳米测定法，以选择性地检测有毒病原体，并可能研究多功能纳米颗粒以选择性地从饮用水中清除有毒病原体。 第2次对象研究纳米颗粒的毒性是环境因素的函数：实验研究和计算模型，包括纳米材料的发展和生产的不同方面以及对其毒性的研究。总体目标是开发一种操作模型，用于指导绿色金属氧化物纳米颗粒的产生，并在选定的环境条件下使用工程的金属氧化物纳米颗粒在选定的环境条件下进行体外和体内毒理学研究。此外，进行计算研究以开发可靠的计算模型，可有效预测纳米材料的物理化学特征和毒性。这两个研究领域都是强烈的互连和设计，旨在增强纳米材料的基本特性和环境特征，毒性和应用的知识。该中心利用通用设计用于学习模型，以最大程度地提高不同学生群体的学习成果。