CREST Center for Biological Signatures and Sensing (BioSS) Phase II

CREST 生物特征和传感中心 (BioSS) 第二期

• 批准号: 2112556
• 负责人: Arnold Burger
• 金额: $ 500万
• 依托单位: Fisk University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2112556&HistoricalAwards=false
• 关键词: CREST; Center; Biological; Signatures; Sensing

Center for Biological Signatures and SensingThe Centers of Research Excellence in Science and Technology (CREST) program supports the enhancement of research capabilities of minority-serving institutions through the establishment of centers that effectively integrate education and research. CREST promotes the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students historically underrepresented in science, technology, engineering, and mathematics disciplines. With National Science Foundation support, Fisk University strengthens the Center for Biological Signatures and Sensing (BioSS). The Center develops sensor technology that increases the knowledge and development of biological, chemical, and nuclear sensors for biological applications. Each of three research areas engages a multidisciplinary team of natural scientists partnering with mathematicians and computer scientists to develop or adapt new tools to solve high profile biological problems. The Center enhances Fisk University curricula to include emerging topics in biological sensors and materials science. The project provides research experience, professional development, mentoring and career guidance for a diverse and new generation of students in the emerging areas of sensor technology. The Center articulates three research subprojects addressing biological sensing modalities that are the basis of the next generation of sensors serving a multitude of applications. Subproject 1 focuses on genetic signatures and sensing of cellular identity and function in dopamine neurons in actively proliferating mammalian cells. This team uses various combinations of genetically encoded sensors, transcriptional profiling, and microfluidics to determine epigenetic modifiers of gene expression, and therefore of cellular function and behavior. Subproject 2 develops biochemical mechanisms of metal sensing from structure-function relationships of proteins to cellular homeostasis. This team integrates biophysical, biochemical, and computational approaches to reveal the molecular basis for protein-metal interactions and their role in the regulation of fundamental biological processes, extending previous work focused on manganese to include iron, copper, and zinc. Subproject 3 develops and implements novel radiation sensors for biological applications. This team continues the material discovery component and further develops dual-energy x-ray absorptivity handheld sensors and micro-cameras providing chemical specificity, detection of biogenetic molecules, and other assays involving gamma and neutron spectroscopy applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物特征和传感中心科学技术卓越研究中心（CREST）计划通过建立有效整合教育和研究的中心，支持提高少数民族服务机构的研究能力。 CREST促进新知识的发展，提高个别教师的研究生产力，并扩大历史上在科学，技术，工程和数学学科中代表性不足的学生的存在。 在国家科学基金会的支持下，菲斯克大学加强了生物特征和传感中心（BioSS）。 该中心开发传感器技术，增加生物，化学和核传感器的生物应用的知识和发展。 三个研究领域中的每一个都有一个多学科的自然科学家团队与数学家和计算机科学家合作，开发或改造新的工具来解决备受瞩目的生物学问题。 该中心加强了菲斯克大学的课程，包括生物传感器和材料科学的新兴课题。 该项目为传感器技术新兴领域的多元化和新一代学生提供研究经验，专业发展，指导和职业指导。 该中心阐述了三个研究子项目，解决生物传感模式，是下一代传感器服务于多种应用的基础。 子项目1的重点是在活跃增殖的哺乳动物细胞中多巴胺神经元的遗传特征和细胞身份和功能的传感。 该团队使用遗传编码传感器，转录分析和微流体的各种组合来确定基因表达的表观遗传修饰剂，从而确定细胞功能和行为。 子计画2从蛋白质的结构与功能关系到细胞内稳态，发展金属感测的生化机制。该团队整合了生物物理，生物化学和计算方法，以揭示蛋白质-金属相互作用的分子基础及其在基本生物过程调节中的作用，将以前的工作重点扩展到锰，包括铁，铜和锌。 分项目3开发和实现用于生物应用的新型辐射传感器。该团队继续材料发现部分，并进一步开发双能X射线吸收率手持传感器和微型相机，提供化学特异性，检测生物分子，以及其他涉及伽马和中子光谱应用的分析。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Advanced inorganic halide ceramic scintillators

先进无机卤化物陶瓷闪烁体

• DOI: 10.1016/j.optmat.2021.111307
• 发表时间: 2021
• 期刊: Optical Materials
• 影响因子: 3.9
• 作者: Hawrami, R.;Ariesanti, E.;Burger, A.;Parkhe, H.
• 通讯作者: Parkhe, H.

Speaking up for the invisible minority: First‐generation students in higher education

为看不见的少数群体发声：高等教育中的第一代学生

• DOI: 10.1002/jcp.31158
• 发表时间: 2024
• 期刊: Journal of Cellular Physiology
• 影响因子: 5.6
• 作者: Kamalumpundi, Vijayvardhan;Silvers, Sophielle;Franklin, Latisha;Neikirk, Kit;Spencer, Elsie;Beasley, Heather K.;Wanajalla, Celestine N.;Vue, Zer;Crabtree, Amber;Kirabo, Annet
• 通讯作者: Kirabo, Annet

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

• DOI: 10.1002/adbi.202300186
• 发表时间: 2023-08-21
• 期刊: ADVANCED BIOLOGY
• 影响因子: 3.7
• 作者: Crabtree, Amber;Neikirk, Kit;Hinton Jr, Antentor
• 通讯作者: Hinton Jr, Antentor

Latest updates in growth and performance of Ce-doped Tl2LaCl5 and Tl2GdBr5 and Eu-doped TlCa2Br5 and TlSr2I5

Ce 掺杂 Tl2LaCl5 和 Tl2GdBr5 以及 Eu 掺杂 TlCa2Br5 和 TlSr2I5 生长和性能的最新更新

• DOI: 10.1016/j.optmat.2021.111495
• 发表时间: 2021
• 期刊: Optical Materials
• 影响因子: 3.9
• 作者: Hawrami, R.;Ariesanti, E.;Burger, A.;Parkhe, H.
• 通讯作者: Parkhe, H.

Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat

• DOI: 10.1021/acsinfecdis.3c00490
• 发表时间: 2023-11-13
• 期刊: ACS INFECTIOUS DISEASES
• 影响因子: 5.3
• 作者: Stephens，Victoria R.;Moore，Rebecca E.;Gaddy，Jennifer A.
• 通讯作者: Gaddy，Jennifer A.