CAREER: Detection and quantification of metal-based engineered nanoparticles in surface waters

职业：地表水中金属基工程纳米颗粒的检测和定量

• 批准号: 1553909
• 负责人: Mohammed Baalousha
• 金额: $ 51万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1553909&HistoricalAwards=false
• 关键词: CAREER; Detection; quantification; metal; based

Proposal: 1553909PI: Baalousha, Mohammed Engineered nanoparticles are currently considered as an emerging contaminant because their increased production and use in consumer products leads to release into the environment. Risk assessment of nanotechnology to humans or the environment, resulting from increased accumulations of engineered nanoparticles in aquatic systems, is currently impeded by the difficulty in differentiating engineered nanoparticles from naturally occurring nanoparticles and quantifying engineered nanoparticle exposure concentrations and properties. This CAREER award aims to develop methods to discern engineered and natural nanoparticles and to measure the concentration and properties of engineered nanoparticles in the natural environment. This CAREER award will develop a multi-method analytical platform capable of discerning engineered nanoparticles from natural nanoparticles based on differences in their physicochemical properties such as size, morphology, chemical composition, elemental/isotopic ratios, and/or combinations of these properties. The hypothesis is that engineered nanoparticles possess significantly different physicochemical properties, relative to natural nanoparticles, which will enable detection and quantification engineered nanoparticles in complex matrices. The multi-method approach includes field flow fractionation coupled with inductively coupled plasma-mass spectroscopy, single particle-ICP-MS and transmission electron microscopy coupled with X-ray energy dispersive spectroscopy techniques and methodologies. In particular, the research will evaluate the capability of these methods to identify subtle differences in physicochemical properties of engineered versus natural nanoparticles to: 1) enable detection and quantification of engineered nanoparticles, 2) determine applicability and limitations of these methods for engineered nanoparticle analysis in surface waters, 3) perform analysis of engineered nanoparticles in surface waters receiving effluents from waste treatment plants, and 4) apply the multi-method approach for monitoring of engineered nanoparticles in surface waters in collaboration with the USGS.The outcomes of the proposed research will impact other disciplines such as aquatic toxicology and environmental nanoscience and engineering. Quantifying concentrations and properties of engineered nanoparticles in surface waters will affect engineered nanoparticle hazard and risk characterization by focusing on the form of engineered nanoparticles after their transformations in the environment. Also, measuring the concentrations and properties of engineered nanoparticles in surface waters will enable validation of engineered nanoparticles fate models. The outcome of the proposed research will also inform federal agencies (e.g. EPA, NIST, and USGS) and industry on nanoparticle regulation and best safety practices.To integrate research, education and service, the PI will: 1) develop undergraduate and graduate lectures and courses in environmental nanoscience, 2) edit books that can be used as text book material, 3) enhance undergraduate, graduate, and high school laboratory and field experiences, 4) develop a professional training program for high school teachers, 5) enhance high school students awareness of nanotechnology and the opportunities and challenges it may offer, 6) train students on reviewing proposals, 7) involve students in grants development and writing, and 7) organize the FFF2018 symposium, and a meeting and discussion of high school student with international researchers.

提案：1553909 PI：工程纳米颗粒目前被认为是一种新兴的污染物，因为它们在消费品中的生产和使用增加导致释放到环境中。纳米技术对人类或环境的风险评估，由于工程纳米粒子在水生系统中的积累增加，目前阻碍了工程纳米粒子从天然存在的纳米粒子区分和量化工程纳米粒子暴露浓度和属性的困难。该职业奖旨在开发识别工程和天然纳米颗粒的方法，并测量工程纳米颗粒在自然环境中的浓度和性质。该CAREER奖项将开发一个多方法分析平台，能够根据其物理化学性质的差异，如大小，形态，化学成分，元素/同位素比和/或这些性质的组合，从天然纳米颗粒中辨别工程纳米颗粒。该假设是，工程纳米粒子具有显着不同的物理化学性质，相对于天然纳米粒子，这将使检测和定量工程纳米粒子在复杂的矩阵。多方法的方法包括场流分馏耦合电感耦合等离子体质谱，单粒子ICP-MS和透射电子显微镜耦合X射线能量色散光谱技术和方法。特别是，该研究将评估这些方法识别工程与天然纳米颗粒物理化学性质的细微差异的能力，以：1）能够检测和定量工程化纳米颗粒，2）确定这些方法用于表面沃茨中工程化纳米颗粒分析的适用性和局限性，3）在接收来自废物处理厂的流出物的表面沃茨中进行工程纳米颗粒的分析，（4）多功能与美国地质勘探局合作，监测地表沃茨中工程纳米颗粒的方法。拟议研究的结果将影响其他学科，水生毒理学和环境纳米科学与工程。量化表面沃茨中工程纳米颗粒的浓度和性质将通过关注工程纳米颗粒在环境中转化后的形式来影响工程纳米颗粒的危害和风险表征。此外，测量表面沃茨中工程纳米颗粒的浓度和性质将使工程纳米颗粒归宿模型的验证成为可能。拟议研究的结果也将告知联邦机构（如EPA、NIST和USGS）和工业界就纳米颗粒法规和最佳安全实践进行合作。为了整合研究、教育和服务，PI将：1）开发环境纳米科学的本科生和研究生讲座和课程，2）编辑可用作教科书材料的书籍，3）加强本科生，研究生，和高中实验室和实地经验，4）为高中教师制定专业培训计划，5）提高高中学生对纳米技术及其可能提供的机遇和挑战的认识，6）培训学生审查提案，7）让学生参与赠款开发和写作，7）组织FFF 2018研讨会，以及高中生与国际研究人员的会议和讨论。

项目成果

Multi-method approach for analysis of road dust particles: elemental ratios, SP-ICP-TOF-MS, and TEM

道路灰尘颗粒分析的多方法：元素比、SP-ICP-TOF-MS 和 TEM

• DOI: 10.1039/d2en00409g
• 发表时间: 2022
• 期刊: Environmental Science: Nano
• 作者: Tou, Feiyun;Nabi, Md. Mahmudun;Wang, Jingjing;Erfani, Mahdi;Goharian, Erfan;Chen, Jing;Yang, Yi;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed

Analysis of complex particle mixtures by asymmetrical flow field-flow fractionation coupled to inductively coupled plasma time-of-flight mass spectrometry

通过不对称流场流分级与电感耦合等离子体飞行时间质谱分析复杂颗粒混合物

• DOI: 10.1016/j.chroma.2021.461981
• 发表时间: 2021
• 期刊: Journal of Chromatography A
• 影响因子: 4.1
• 作者: Meili-Borovinskaya, Olga;Meier, Florian;Drexel, Roland;Baalousha, Mohammed;Flamigni, Luca;Hegetschweiler, Andreas;Kraus, Tobias
• 通讯作者: Kraus, Tobias

Detection and quantification of anthropogenic titanium-, cerium-, and lanthanum-bearing home dust particles

人为含钛、铈和镧的家庭灰尘颗粒的检测和定量

• DOI: 10.1039/d2en00890d
• 发表时间: 2023
• 期刊: Environmental Science: Nano
• 作者: Nabi, Md Mahmudun;Wang, Jingjing;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed

Sewage spills are a major source of titanium dioxide engineered (nano)-particle release into the environment

• DOI: 10.1039/c8en01376d
• 发表时间: 2019-03-01
• 期刊: ENVIRONMENTAL SCIENCE-NANO
• 影响因子: 7.3
• 作者: Loosli, Frederic;Wang, Jingjing;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed

Episodic surges in titanium dioxide engineered particle concentrations in surface waters following rainfall events

降雨事件后，地表水中二氧化钛工程颗粒浓度出现间歇性激增

• DOI: 10.1016/j.chemosphere.2020.128261
• 发表时间: 2021
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Nabi, Md Mahmudun;Wang, Jingjing;Baalousha, Mohammed
• 通讯作者: Baalousha, Mohammed