CAREER: Stereoselective and Rate-enhanced H-bonding Catalysts for Ring-Opening Polymerization

职业：用于开环聚合的立体选择性和速率增强的氢键催化剂

• 批准号: 1554830
• 负责人: Matthew Kiesewetter
• 金额: $ 66.83万
• 依托单位: University of Rhode Island
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1554830&HistoricalAwards=false
• 关键词: CAREER; Stereoselective; Rate; enhanced; bonding

Given the tremendous burden of polymer production on natural resources and the vast amount of the US economy derived as a result of manufacturing and selling these materials, the development of efficient processes for polymer synthesis is of great societal importance. In this research supported by the Macromolecular, Supramolecular and Nanochemistry Program of the Division of Chemistry, Prof. Kiesewetter of the Rhode Island University conducts aims to develop more efficient catalysts that function under mild reaction conditions and enable better control of the polymer structures. Graduate and undergraduate students who conduct this research receive training in catalyst development as well as polymer synthesis and characterization. In addition, a series of polymer science based workshops are being established for Rhode Island educators, including high school teachers, post-secondary lecturers, and community college professors. This research aims to develop rate enhanced catalysts and stereoselective catalysts for ring-opening polymerization. For these aims, the Kiesewetter group investigates the catalytic properties of dual H-bond donors, a largely unexplored class of catalysts. Specifically, his group designs and synthesizes achiral and chiral bisthioureas, as well as develops a mechanistic understanding of their catalytic properties through a multifaceted approach involving spectroscopic studies, chemical kinetics and thermodynamic studies.

考虑到聚合物生产对自然资源的巨大负担以及由于制造和销售这些材料而产生的大量美国经济，开发用于聚合物合成的有效方法具有重大的社会重要性。 在这项由化学系大分子，超分子和纳米化学计划支持的研究中，罗得岛大学的Kiesewetter教授进行的研究旨在开发更有效的催化剂，这些催化剂在温和的反应条件下发挥作用，并能够更好地控制聚合物结构。 进行这项研究的研究生和本科生接受催化剂开发以及聚合物合成和表征方面的培训。 此外，正在为罗得岛教育工作者，包括高中教师、中学后讲师和社区大学教授建立一系列以聚合物科学为基础的讲习班。 本研究旨在开发开环聚合的速率增强型催化剂和立体选择性催化剂。 为了实现这些目标，Kiesewetter小组研究了双氢键供体的催化性能，这是一类基本上未开发的催化剂。 具体来说，他的团队设计和合成非手性和手性双硫脲，并通过光谱研究、化学动力学和热力学研究等多方面方法对其催化性能进行机理理解。