Stereoselective organo-metal catalysis for the synthesis of value-added products

用于合成增值产品的立体选择性有机金属催化

• 批准号: 2762999
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2762999
• 关键词: Stereoselective; organo; metal; catalysis; synthesis

The ability of chemists to invent new transformations is at heart of our modern society, as novel chemical methods to forge bonds with increased precision and selectivity enable more efficient preparation of materials, medicines, agrochemicals and fine chemicals. Catalysis is a powerful tool to devise new reactions and render the existing ones more selective, thus contributing to a more sustainable use of natural resources. In this context, the present PhD project merges in original ways elements taken from both organo- and transition-metal catalysis, to open new paths for stereoselective reactions of unsaturated feedstock substrates and for sustainable synthesis oriented to medicinally relevant scaffolds.The PhD student will design and prepare novel organocatalysts capable of engaging with common metal halide (pre)catalysts via non-covalent interactions. These binary catalytic systems will then be employed in a large variety of reactions to achieve increased rate, unusual regio- and stereoselectivity and/or unprecedented levels of enantiocontrol starting from minimally functionalised, electronically unbiased substrates.

化学家发明新的转化的能力是我们现代社会的核心，因为新的化学方法可以以更高的精度和选择性建立键合，从而能够更有效地制备材料，药物，农用化学品和精细化学品。催化是设计新反应并使现有反应更具选择性的有力工具，从而有助于更可持续地利用自然资源。在此背景下，本博士项目将有机金属和过渡金属催化元素以独创的方式融合，为不饱和原料底物的立体选择性反应和面向医学相关支架的可持续合成开辟新途径。博士生将设计和制备新型有机催化剂，能够通过非共价相互作用与常见的金属卤化物（前）催化剂接合。这些二元催化体系将被用于各种各样的反应，以实现增加的速率，不寻常的区域和立体选择性和/或前所未有的水平的对映体控制从最低限度的官能化，电子无偏底物。