Tolerance as a Parasite Defense in a Colonial Bird

耐受性作为殖民地鸟类的寄生虫防御

• 批准号: 1556356
• 负责人: Charles Brown
• 金额: $ 28.31万
• 依托单位: University of Tulsa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1556356&HistoricalAwards=false
• 关键词: Tolerance; Parasite; Defense; Colonial; Bird

All living organisms must defend themselves from disease-causing parasites and pathogens to which they are exposed. The typical way that such defense occurs is by resisting the pathogen or parasite, often through an immune response. Resistance by the host is the basis for much of modern medicine, in which the immune response is enhanced or replaced by various therapies. However, another defense is the tolerance of the parasite or pathogen without mounting any resistance, which (under certain circumstances) can be beneficial to the host, in part because tolerance does not require the host to incur the physiological cost of mounting an immune response. Plants are well known to tolerate various pathogens, but the ability of animals to tolerate parasites has only recently been recognized. This project documents how a colonial bird, the cliff swallow, has rapidly evolved (over 30 years) the ability to tolerate large numbers of blood-feeding parasitic bugs. By comparing the effects of these parasites on the birds in the 1980s versus their effects today, insight into conditions that favor the development of tolerance as a parasite defense in a social animal will be gained. The results will have wide relevance to understanding ways that animals (including humans) can potentially minimize the negative effects of parasites and the diseases sometimes associated with those parasites.Parasite tolerance has been established as a key host defense in plant-parasite systems, but few empirical studies have explored the role of tolerance in animal host-parasite relationships. This research seeks to study the ecology and evolution of tolerance defense strategies against parasites in colonially nesting cliff swallows (Petrochelidon pyrrhonota) and their principal parasite, the swallow bug (Hemiptera: Cimicidae: Oeciacus vicarius). The work builds on a long-term field study and the relatively recent adoption of new nesting sites by cliff swallows where they have come into greater contact with their nest parasites. During the 1980s, bugs exerted severe effects on cliff swallow reproductive success, but subsequent observation suggests that the birds may have evolved greater tolerance to parasitism in the intervening 30 years. This research seeks to establish whether cliff swallows now better tolerate parasites and how the birds? anti-parasite behavior may be changing as a result. The novelty of this work is that it is the first to examine temporal changes in tolerance within a natural population. This research will involve undergraduate students and a postdoctoral scientist, and participation by a community college faculty member will facilitate involvement of urban minority students. Because enhancing tolerance by the host may be more effective in fighting inflammatory and autoimmune diseases than prescribing antibiotics (a strategy that promotes resistance to parasites), this research will encourage non-scientists to think about tolerance as a treatment option.

所有生物体都必须保护自己免受它们所接触的致病寄生虫和病原体的侵害。 这种防御发生的典型方式是抵抗病原体或寄生虫，通常通过免疫反应。 宿主的耐药性是许多现代医学的基础，其中免疫反应被各种疗法增强或取代。 然而，另一种防御是寄生虫或病原体的耐受性而不产生任何抗性，这（在某些情况下）可能对宿主有益，部分原因是耐受性不需要宿主承担产生免疫应答的生理代价。 众所周知，植物可以耐受各种病原体，但动物耐受寄生虫的能力直到最近才被认识到。 这个项目记录了一种殖民鸟类，悬崖燕子，如何快速进化（超过30年）容忍大量吸血寄生虫的能力。 通过比较这些寄生虫在20世纪80年代对鸟类的影响与它们今天的影响，将获得对有利于社会动物中作为寄生虫防御的耐受性发展的条件的洞察。 这些结果将对理解动物（包括人类）如何最大限度地减少寄生虫的负面影响以及有时与这些寄生虫相关的疾病具有广泛的相关性。寄生虫耐受性已被确立为植物-寄生虫系统中的关键宿主防御，但很少有实证研究探讨耐受性在动物宿主-寄生虫关系中的作用。本研究旨在研究生态学和进化的耐受防御策略，对寄生虫在殖民筑巢的悬崖燕子（Petrochelidon pyrrhonota）和他们的主要寄生虫，燕子错误（半翅目：Cimicidae：Oeciacus vicarius）。 这项工作建立在一项长期的实地研究和相对较新的悬崖燕子采用新的筑巢地点，在那里他们与他们的巢寄生虫有更多的接触。 在20世纪80年代，昆虫对崖燕的繁殖成功产生了严重影响，但随后的观察表明，在这30年中，鸟类可能进化出了更大的寄生耐受力。 这项研究旨在确定悬崖燕子现在是否更好地容忍寄生虫，以及鸟类如何？抗寄生虫的行为可能因此而改变。 这项工作的新奇在于，它是第一个研究自然人群中耐受性的时间变化。 这项研究将涉及本科生和一名博士后科学家，社区学院教员的参与将促进城市少数民族学生的参与。 因为增强宿主的耐受性可能比开抗生素（一种促进寄生虫抗性的策略）更有效地对抗炎症和自身免疫性疾病，这项研究将鼓励非科学家考虑将耐受性作为一种治疗选择。