权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

New catalytic chemistry based on borylation of alkynes

基于炔烃硼化的新型催化化学

基本信息

批准号：
1565923
负责人：
Oleg Ozerov
金额：
$ 45万
依托单位：
Texas A&M University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565923&HistoricalAwards=false
关键词：
New catalytic chemistry based borylation

项目摘要

The Chemical Catalysis Program of the Chemistry Division supports the project by Professor Oleg Ozerov, a faculty member in the Department of Chemistry at Texas A&M University. The work in the Ozerov group straddles the fields of organic and inorganic chemistry. His group is exploring recently discovered catalytic processes to introduce carbon-boron bonds into organic compounds, especially around carbon-carbon triple bonds (alkynes) and double bonds (alkenes). The importance of these borylated compounds is in their versatility as building blocks for more complex organic molecules, with potential applications in the synthesis of pharmaceuticals and new materials. The project benefits from a network of US and international collaborators, including those at primarily undergraduate institutions (PUI). It also serves as a vehicle for broadening participation in the Texas A&M graduate program and educating Texas A&M graduate students about PUI careers and introducing them to secondary school outreach.The primary goal of this project is the exploration of the full potential of dehydrogenative borylation of terminal alkynes (DHBTA) and the reactions derived from it. Successful implementation of the borylation processes of interest requires development of molecular transition metal catalysts in a framework of specifically designed supporting ligands. The project aims to gain fundamental insight into the mechanism of iridium-catalyzed DHBTA and other borylation reactions and the role of the supporting ligand in influencing reaction outcomes. Other goals being investigated include 1) the cyclization reactions of DHBTA products, alkynylboronates, and 2) the potential of the DHBTA-inspired reactivity in catalysis of other C-H borylation reactions. Undergraduate students are involved directly in the Ozerov group and via collaboration with Prof. Larsen at Ithaca College and other PUI faculty. PUI collaborations introduce Texas A&M graduate students to PUI opportunities and careers and draw more undergraduates into research and into graduate education.

化学部门的化学催化项目支持奥列格·奥泽罗夫教授的项目，他是德克萨斯农工大学化学系的教员。Ozerov小组的工作跨越了有机化学和无机化学领域。他的团队正在探索最近发现的将碳硼键引入有机化合物的催化过程，特别是碳碳三键（炔烃）和双键（烯烃）。这些硼化化合物的重要性在于它们作为更复杂的有机分子的构建块的多功能性，在药物和新材料的合成中具有潜在的应用。该项目得益于美国和国际合作者的网络，包括那些主要的本科院校（PUI）。它还作为一个工具，扩大参与德州农工大学研究生项目，教育德州农工大学研究生关于PUI职业的知识，并向他们介绍中学外展。本项目的主要目标是探索末端炔的脱氢硼化反应（DHBTA）及其衍生反应的全部潜力。成功实现感兴趣的硼化过程需要在专门设计的支持配体框架中开发分子过渡金属催化剂。该项目旨在从根本上了解铱催化的DHBTA和其他硼化反应的机理，以及支持配体对反应结果的影响。其他正在研究的目标包括1)DHBTA产物的环化反应，炔基硼酸盐，以及2)DHBTA激发的反应性催化其他C-H硼化反应的潜力。本科生直接参与Ozerov小组，并与伊萨卡学院的Larsen教授和其他PUI教师合作。PUI的合作为德州农工大学的研究生提供了PUI的机会和职业，并吸引了更多的本科生从事研究和研究生教育。