Positive Contrast MRI for Imaging Small Interventional Devices

1606136磁共振成像在确定治疗靶区方面的熟练程度使其成为外科干预手术前计划的有力工具。然而，当涉及介入设备时，磁共振成像面临着独特的挑战。大多数设备是看不见的，或者很难用MRI可视化。该项目将开发一种新的敏感性标测技术，以实现前列腺癌近距离放射治疗种子的快速对比磁共振成像。从长远来看，这项技术将使神经外科中的脑深部刺激(DBS)成为可能。这些成果将被整合到推广和教育活动中，以激发不同学生群体对生物医学成像的兴趣。该项目将通过一年一度的研讨会和实验室研究，在当地高中生和女学生中促进生物医学成像研究。一个关键的见解是，有可能将小型介入设备的磁敏性从讨厌变成有用的信息。PI使用每个设备固有的磁化率进行正对比成像，这是介入性磁共振成像中的一个新概念。该项目将a)开发快速3D脉冲序列，用于敏感性测绘，在图像失真方面是稳健的；b)将快速序列、压缩传感和并行成像与可穿戴的骨盆尿布线圈相集成，以加速数据采集；以及c)使用逼真的组织模拟骨盆模型，在4.7特斯拉动物扫描仪和3特斯拉全身扫描仪上验证该技术。该项目将建立在一个多学科调查团队的初步工作基础上，该团队在磁共振物理、成像系统和医学研究方面具有互补的专业知识。

1606136 The proficiency of Magnetic Resonance Imaging (MRI) in defining target areas for treatment makes it a powerful tool for pre-operation planning in surgical interventions. However MRI faces unique challenges when interventional devices are involved. Most devices are invisible or difficult to visualize with MRI. This project will develop a novel susceptibility mapping technology to achieve rapid contrast MRI of brachytherapy seeds for prostate cancer treatment. Longer term this technology will enable deep brain stimulation (DBS) in neurosurgery. These outcomes will be integrated in outreach and educational activities to stimulate interest in biomedical imaging among a diverse group of students. The project will promote biomedical imaging research among local high-school students and female students through an annual workshop and laboratory studies.A key insight is that it is possible to turn the magnetic susceptibility of the small interventional devices from being a nuisance into useful information. The PI uses the magnetic susceptibility inherent in each device for positive-contrast imaging which is a novel concept in interventional MRI. This project will a) develop a fast 3D pulse sequence for susceptibility mapping that is robust in regards to image distortion; b) integrate the fast sequence, compressive sensing and parallel imaging with a wearable pelvic diaper coil to accelerate data acquisition; and c) validate this technique on a 4.7 Tesla animal scanner and on a 3 Tesla whole-body scanner using a realistic tissue-mimicking pelvic phantom. The project will be built on the preliminary work of a team of multidisciplinary investigators with complementary expertise in MR physics, imaging systems, and medical research.