Discrete Polymer-based, Metal-free MRI Contrast Agents

项目摘要 合成聚合物的结构分散性对于它们的临床应用和监管批准至关重要。在这 项目中，我们提出了开发含交变轴承的水溶性离散瓶刷聚合物 磷脂和氟化共单体作为无金属19F磁共振造影剂的临床应用 探员们。所提出的聚合物体系的新奇之处在于它结合了：1.离散分子量(AS 与传统分散聚合物相反)；2.支化结构的多功能性；3.高含水率 磷酰胆碱基的溶解性和生物相容性；以及4.外源和化学上相同的信号 共19个F组。合理设计刷子聚合物的结构、共聚单体顺序和 亲油-亲水平衡有望抑制信号展宽并产生离散的合成 基于聚合物的平台，可以进一步扩展到其他靶向成像和传感策略。

Project Summary Structural dispersity in synthetic polymers is paramount for their clinical use and regulatory approval. In this project, we propose the development of water-soluble discrete bottlebrush polymers bearing alternating phospholipid and fluorinated comonomers to enable their clinical applications as metal-free19F MRI contrast agents. The novelty of the proposed polymer system is that it combines: 1. discrete molecular weight (as opposed to conventional disperse polymers); 2. multifunctionality of branched architectures; 3. high water solubility and biocompatibility of phosphorylcholine groups; and 4. exogenous and chemically identical signal of19F groups. Rational design of the brush polymer architecture, comonomer sequence, and lipophilic-hydrophilic balance is anticipated to suppress signal broadening and yield discrete synthetic polymer-based platforms that can be further extended to other targeted imaging and sensing strategies.