First Principles Design of Second-Generation Protein Stains

第二代蛋白质染料的第一原理设计

• 批准号: DP0877999
• 负责人: Prof Peter Karuso
• 金额: $ 6.5万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877999
• 关键词: First; Principles; Design; Second; Generation

Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the technology can mature to the stage where its full potential is realized. We will enable the evolution of proteomics by devising second generation fluorescent protein stains, using the environmentally-friendly natural product, epicocconone, as our design platform.

蛋白质组学是一门新兴的技术，它有可能彻底改变现代生物学和医学。 非常敏感的蛋白质染色是一种关键的蛋白质组学技术，与凝胶电泳结合，它们有助于快速定量检测细胞中的所有多肽。 然而，蛋白质组学的工具必须迅速发展（更便宜，更高的灵敏度，更可靠，更安全的操作），然后技术才能成熟到充分发挥其潜力的阶段。 我们将通过设计第二代荧光蛋白染色剂，使用环境友好的天然产物epicocconone作为我们的设计平台，实现蛋白质组学的发展。