Adaptive evolution of cellular differentiation programs in the alpha-proteobacterium Hyphomonas neptunium (E04 (B05))

α-变形杆菌镎状单胞菌 (E04 (B05)) 中细胞分化程序的适应性进化

• 批准号: 224593614
• 金额: --
• 依托单位: Arbeitsgruppe Prokaryotische Zellbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/224593614?language=en
• 关键词: Adaptive; evolution; cellular; differentiation; programs

The goal of this project is to understand how environmental conditions shape the develop-mental programs of bacterial cells, thereby enhancing their fitness and long-term survival in the niches they inhabit. To this end, we will compare the layouts of the signalling networks controlling cellular development in the marine species Hyphomonas neptunium and the freshwater species Caulobacter crescentus, two closely related alphaproteobacteria that have evolved very different modes of growth and proliferation. The results will pinpoint common design principles in the regulatory pathways and help rationalize the differences between the two systems.

该项目的目标是了解环境条件如何塑造细菌细胞的发育程序，从而增强它们在栖息环境中的适应性和长期生存能力。为此，我们将比较的布局的信号网络控制细胞的发展，在海洋物种丝单胞菌neptunium和淡水物种Caulobacter crescentus，两个密切相关的alphaproteobacteria，已经演变成非常不同的模式的增长和增殖。研究结果将确定监管途径中的共同设计原则，并有助于合理化两个系统之间的差异。