Investigating the evolution of innate and adaptive cellular immunity

该提案旨在评估澳大利亚土著人口的地理和遗传隔离对适应性和先天免疫系统的影响。该项目将使用新的DNA测序方法，生成调节先天性和适应性免疫反应的两个遗传基因座的高分辨率序列，即主要组织相容性复合体基因座和杀伤细胞免疫球蛋白样受体基因座。在最初的筛选中，鉴定了这些基因的不同变体和组合。该项目旨在研究这些关键基因的变异如何影响细胞毒性淋巴细胞的功能，从而深入了解免疫识别机制的进化驱动因素。

This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.